| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #79 | $7,326.1万 | 510.9万股 | $4,153.4万 | 445.6万股 | +65.2万股+14.64% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #60 | $7,049.1万 | 491.6万股 | $2,993.5万 | 321.2万股 | +170.4万股+53.05% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.21% | 0.12% | #12 | $6,862.8万 | 478.6万股 | $3,216.3万 | 345.1万股 | +133.5万股+38.68% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #88 | $3,784.2万 | 263.9万股 | $2,301.4万 | 246.9万股 | +17.0万股+6.87% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.15% | 0.13% | #14 | $3,187.5万 | 222.3万股 | $2,193.1万 | 235.3万股 | -13.0万股-5.54% | 减仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.86% | 0.87% | #5 | $2,577.6万 | 179.7万股 | $2,350.4万 | 252.2万股 | -72.4万股-28.73% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #91 | $2,412.0万 | 168.2万股 | $1,455.4万 | 156.2万股 | +12.0万股+7.71% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #76 | $2,210.3万 | 154.1万股 | $1,278.9万 | 137.2万股 | +16.9万股+12.32% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | <0.01% | #39 | $1,874.2万 | 130.7万股 | $788.9万 | 84.6万股 | +46.0万股+54.40% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.02% | 0.01% | #35 | $1,780.1万 | 124.1万股 | $785.0万 | 84.2万股 | +39.9万股+47.37% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #84 | $1,726.4万 | 120.4万股 | $528.7万 | 55.6万股 | +64.8万股+116.54% | 加仓 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | <0.01% | #55 | $1,723.2万 | 120.2万股 | $1,084.0万 | 116.3万股 | +3.9万股+3.32% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #62 | $1,374.8万 | 95.9万股 | $516.8万 | 55.5万股 | +40.4万股+72.82% | 加仓 |
| Royce联营ROYCE & ASSOCIATES LP |
| 0.1% | 0.09% | #19 | $1,265.7万 | 88.3万股 | $921.4万 | 98.9万股 | -10.6万股-10.72% | 减仓 |
| 683 Capital Management, LLC |
| 0.6% | 0.47% | #6 | $1,226.1万 | 85.5万股 | $908.7万 | 97.5万股 | -12.0万股-12.31% | 减仓 |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 1.14% | 0.79% | #3 | $1,111.4万 | 77.5万股 | $722.3万 | 77.5万股 | 00.00% | 持仓不变 |
| Retirement Planning Co of New England, Inc. |
| 3.27% | 2.47% | #1 | $909.7万 | 63.4万股 | $606.9万 | 65.1万股 | -1.7万股-2.57% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| <0.01% | — | #56 | $879.6万 | 61.3万股 | $0 | 0股 | +61.3万股 | 新买入 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #54 | $856.3万 | 59.7万股 | $0 | 0股 | +59.7万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #94 | $782.3万 | 54.6万股 | $714.6万 | 76.7万股 | -22.1万股-28.85% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #109 | $776.0万 | 54.1万股 | $434.6万 | 46.6万股 | +7.5万股+16.04% | 加仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.01% | 0.01% | #38 | $725.4万 | 50.6万股 | $536.7万 | 57.6万股 | -7.0万股-12.15% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #87 | $697.6万 | 48.6万股 | $407.2万 | 43.7万股 | +5.0万股+11.34% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #98 | $685.4万 | 47.8万股 | $656.9万 | 70.5万股 | -22.7万股-32.18% | 减仓 |
| 瑞典银行Swedbank AB |
| 0.01% | — | #45 | $630.1万 | 43.9万股 | $0 | 0股 | +43.9万股 | 新买入 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #50 | $615.5万 | 43.9万股 | $444.3万 | 50.6万股 | -6.7万股-13.18% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #92 | $611.4万 | 42.6万股 | $850.1万 | 91.2万股 | -48.6万股-53.25% | 减仓 |
| Stratos财富合伙人Stratos Wealth Partners, LTD. |
| 0.06% | 0.04% | #23 | $585.1万 | 40.8万股 | $380.3万 | 40.8万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #99 | $584.1万 | 40.7万股 | $426.0万 | 45.7万股 | -5.0万股-10.89% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #75 | $573.9万 | 40.0万股 | $369.0万 | 39.6万股 | +4,329股+1.09% | 加仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.16% | 0.06% | #13 | $550.2万 | 38.4万股 | $165.1万 | 17.7万股 | +20.7万股+116.58% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #113 | $505.7万 | 36.1万股 | $332.7万 | 37.9万股 | -1.8万股-4.75% | 减仓 |
| Mystic Asset Management, Inc. |
| 1.08% | 0.78% | #4 | $504.9万 | 35.2万股 | $336.7万 | 36.1万股 | -9,173股-2.54% | 减仓 |
| 普特南投资管理FLPUTNAM INVESTMENT MANAGEMENT CO |
| 0.06% | 0.05% | #22 | $500.2万 | 34.9万股 | $326.7万 | 35.1万股 | -1,677股-0.48% | 减仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #61 | $465.3万 | 32.5万股 | $171.5万 | 18.4万股 | +14.1万股+76.36% | 加仓 |
| Phocas Financial Corp. |
| 0.59% | 0.23% | #7 | $424.3万 | 29.6万股 | $148.6万 | 15.9万股 | +13.6万股+85.61% | 加仓 |
| Janney Montgomery Scott LLC |
| 0.01% | 0.01% | #43 | $390.3万 | 27.2万股 | $220.7万 | 23.7万股 | +3.5万股+14.93% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #111 | $379.1万 | 26.4万股 | $30.6万 | 3.3万股 | +23.2万股+704.25% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.57% | 1.79% | #8 | $371.0万 | 25.9万股 | $447.4万 | 48.0万股 | -22.1万股-46.10% | 减仓 |
| Propel Bio Management, LLC |
| 1.9% | 1.66% | #2 | $363.6万 | 25.4万股 | $264.1万 | 28.2万股 | -2.9万股-10.22% | 减仓 |
| Diametric Capital, LP |
| 0.35% | 0.26% | #10 | $331.9万 | 23.1万股 | $100.7万 | 10.8万股 | +12.3万股+114.27% | 加仓 |
| Allspring环球投资Allspring Global Investments Holdings, LLC |
| <0.01% | — | #48 | $299.5万 | 21.7万股 | $0 | 0股 | +21.7万股 | 新买入 |
| Group One交易GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #53 | $288.2万 | 20.1万股 | $194.2万 | 20.8万股 | -7,400股-3.55% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #52 | $286.8万 | 20.0万股 | $186.4万 | 20.0万股 | 00.00% | 持仓不变 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #101 | $284.6万 | 19.8万股 | $160.7万 | 17.2万股 | +2.6万股+15.08% | 加仓 |
| GLOBEFLEX CAPITAL L P |
| 0.35% | — | #9 | $275.2万 | 19.2万股 | $0 | 0股 | +19.2万股 | 新买入 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #82 | $273.9万 | 19.1万股 | $74.5万 | 8.0万股 | +11.1万股+138.97% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #108 | $265.0万 | 18.5万股 | $151.0万 | 16.2万股 | +2.3万股+14.10% | 加仓 |
| Inspire Investing, LLC |
| 0.1% | — | #18 | $248.1万 | 17.3万股 | $0 | 0股 | +17.3万股 | 新买入 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #49 | $241.0万 | 16.8万股 | $135.3万 | 14.5万股 | +2.3万股+15.71% | 加仓 |
