| RTW投资RTW INVESTMENTS, LP |
| 1.07% | 1.23% | #6 | $1.25亿 | 657.4万股 | $1.24亿 | 657.4万股 | 00.00% | 持仓不变 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 2.8% | — | #3 | $1.17亿 | 613.8万股 | $0 | 0股 | +613.8万股 | 新买入 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.95% | 1.14% | #8 | $1.09亿 | 574.4万股 | $1.07亿 | 570.7万股 | +3.6万股+0.64% | 加仓 |
| ADAR1 Capital Management, LLC |
| 2.95% | 1.58% | #2 | $6,401.2万 | 336.9万股 | $2,681.1万 | 142.5万股 | +194.4万股+136.36% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #38 | $5,348.9万 | 281.5万股 | $2,374.6万 | 126.2万股 | +155.3万股+123.01% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #36 | $4,399.4万 | 231.5万股 | $208.0万 | 11.1万股 | +220.5万股+1,993.81% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.13% | — | #18 | $4,193.9万 | 220.7万股 | $0 | 0股 | +220.7万股 | 新买入 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.79% | 0.92% | #9 | $3,614.4万 | 190.2万股 | $3,578.3万 | 190.2万股 | 00.00% | 持仓不变 |
| BAMCO(巴伦基金)BAMCO INC /NY/ |
| 0.05% | 0.09% | #22 | $3,085.0万 | 162.4万股 | $3,119.3万 | 165.8万股 | -3.5万股-2.09% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #37 | $2,536.3万 | 133.5万股 | $3,238.8万 | 172.2万股 | -38.7万股-22.47% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.02% | <0.01% | #24 | $2,468.8万 | 129.9万股 | $582.6万 | 31.0万股 | +99.0万股+319.53% | 加仓 |
| Rock Springs Capital Management LP |
| 0.76% | 0.9% | #10 | $1,547.9万 | 81.5万股 | $1,532.5万 | 81.5万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #44 | $1,291.9万 | 68.0万股 | $878.3万 | 46.7万股 | +21.3万股+45.62% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #55 | $1,262.5万 | 66.4万股 | $1,627.3万 | 86.5万股 | -20.1万股-23.20% | 减仓 |
| C WorldWide Group Holding A/S |
| 0.23% | 0.21% | #15 | $969.0万 | 51.0万股 | $959.3万 | 51.0万股 | 00.00% | 持仓不变 |
| B Group, Inc. |
| 4.02% | 6.28% | #1 | $856.2万 | 45.1万股 | $847.7万 | 45.1万股 | 00.00% | 持仓不变 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.01% | 0.01% | #32 | $723.8万 | 39.3万股 | $701.8万 | 39.3万股 | 00.00% | 持仓不变 |
| NAN FUNG TRINITY (HK) Ltd |
| 0.65% | 0.72% | #11 | $658.3万 | 34.6万股 | $651.7万 | 34.6万股 | 00.00% | 持仓不变 |
| 安本标准投资Aberdeen Group plc |
| 0.01% | 0.01% | #28 | $591.5万 | 31.1万股 | $447.2万 | 23.8万股 | +7.4万股+30.94% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #41 | $571.5万 | 30.1万股 | $1.8万 | 959股 | +30.0万股+31,263.40% | 加仓 |
| Spruce Street Capital LP |
| 1.04% | — | #7 | $530.3万 | 27.9万股 | $0 | 0股 | +27.9万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #46 | $481.0万 | 25.3万股 | $458.1万 | 24.4万股 | +9,614股+3.95% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| <0.01% | — | #34 | $469.3万 | 24.7万股 | $0 | 0股 | +24.7万股 | 新买入 |
| Hennion & Walsh Asset Management, Inc. |
| 0.12% | 0.14% | #20 | $437.8万 | 23.0万股 | $403.1万 | 21.4万股 | +1.6万股+7.51% | 加仓 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| 0.01% | <0.01% | #26 | $408.5万 | 21.5万股 | $56.4万 | 3.0万股 | +18.5万股+616.67% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.13% | — | #19 | $380.0万 | 20.0万股 | $0 | 0股 | +20.0万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #53 | $354.1万 | 18.6万股 | $273.6万 | 14.5万股 | +4.1万股+28.13% | 加仓 |
| NEXTBio Capital Management LP |
| 1.6% | 1.6% | #5 | $348.4万 | 18.3万股 | $344.9万 | 18.3万股 | 00.00% | 持仓不变 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 1.87% | 3.71% | #4 | $296.0万 | 15.6万股 | $518.8万 | 27.6万股 | -12.0万股-43.51% | 减仓 |
| Tidal投资Tidal Investments LLC |
| 0.01% | 0.01% | #33 | $292.6万 | 15.4万股 | $345.5万 | 18.4万股 | -3.0万股-16.17% | 减仓 |
| Seven Fleet Capital Management LP |
| 0.48% | 0.46% | #12 | $292.5万 | 13.6万股 | $146.5万 | 7.8万股 | +5.8万股+74.70% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #39 | $279.7万 | 14.7万股 | $0 | 0股 | +14.7万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #43 | $268.2万 | 14.1万股 | $119.0万 | 6.3万股 | +7.8万股+123.20% | 加仓 |
| Privium Fund Management B.V. |
| 0.43% | 0.52% | #13 | $232.2万 | 12.2万股 | $248.6万 | 13.2万股 | -1.0万股-7.56% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #66 | $229.6万 | 12.1万股 | $223.5万 | 11.9万股 | +2,033股+1.71% | 加仓 |
| ALPS顾问ALPS ADVISORS INC |
| 0.01% | 0.01% | #27 | $209.8万 | 11.0万股 | $170.9万 | 9.1万股 | +2.0万股+21.56% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #50 | $193.5万 | 10.2万股 | $327.2万 | 17.4万股 | -7.2万股-41.46% | 减仓 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | <0.01% | #52 | $135.8万 | 7.1万股 | $131.7万 | 7.0万股 | +1,447股+2.07% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #57 | $132.0万 | 6.9万股 | $948.4万 | 50.4万股 | -43.5万股-86.22% | 减仓 |
| Virtus Investment Advisers, LLC |
| 0.3% | 0.25% | #14 | $129.4万 | 6.8万股 | $89.4万 | 4.8万股 | +2.1万股+43.39% | 加仓 |
| Headlands Technologies LLC |
| 0.14% | 0.06% | #17 | $129.2万 | 6.8万股 | $52.9万 | 2.8万股 | +4.0万股+141.95% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #68 | $124.3万 | 6.5万股 | $406.3万 | 12.0万股 | -5.4万股-45.44% | 减仓 |
| DCF Advisers, LLC |
| 0.21% | 0.32% | #16 | $120.7万 | 6.4万股 | $119.4万 | 6.4万股 | 00.00% | 持仓不变 |
| 正交资本Quadrature Capital Ltd |
| 0.01% | — | #29 | $74.2万 | 3.9万股 | $0 | 0股 | +3.9万股 | 新买入 |
| WealthPlan Investment Management, LLC |
| 0.03% | 0.04% | #23 | $69.8万 | 3.7万股 | $69.1万 | 3.7万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #70 | $45.6万 | 2.4万股 | $48.4万 | 2.6万股 | -1,730股-6.73% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #75 | $45.4万 | 2.4万股 | $44.9万 | 2.4万股 | 00.00% | 持仓不变 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #71 | $42.6万 | 2.2万股 | $50.0万 | 2.7万股 | -4,161股-15.67% | 减仓 |
| XTX资本XTX Topco Ltd |
| <0.01% | 0.02% | #35 | $34.9万 | 1.8万股 | $88.5万 | 4.7万股 | -2.9万股-61.02% | 减仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| <0.01% | — | #45 | $29.4万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
