| 富达投资FMR LLC |
| 0.01% | — | #41 | $1.92亿 | 583.5万股 | $0 | 0股 | +583.5万股 | 新买入 |
| Novo Holdings A/S |
| 7.45% | — | #6 | $1.28亿 | 388.3万股 | $0 | 0股 | +388.3万股 | 新买入 |
| SR ONE CAPITAL MANAGEMENT, LP |
| 10.48% | — | #3 | $1.09亿 | 330.9万股 | $0 | 0股 | +330.9万股 | 新买入 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 1.32% | — | #10 | $8,807.1万 | 267.5万股 | $0 | 0股 | +267.5万股 | 新买入 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 1.51% | — | #8 | $8,240.2万 | 250.3万股 | $0 | 0股 | +250.3万股 | 新买入 |
| NVP Associates, LLC |
| 22.75% | — | #1 | $7,467.6万 | 226.8万股 | $0 | 0股 | +226.8万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | — | #34 | $7,248.9万 | 220.2万股 | $0 | 0股 | +220.2万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | — | #44 | $5,712.4万 | 173.5万股 | $0 | 0股 | +173.5万股 | 新买入 |
| Catalio Capital Management, LP |
| 10.37% | — | #4 | $5,516.8万 | 167.6万股 | $0 | 0股 | +167.6万股 | 新买入 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.03% | — | #29 | $5,276.2万 | 160.3万股 | $0 | 0股 | +160.3万股 | 新买入 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.61% | — | #15 | $4,528.1万 | 137.5万股 | $0 | 0股 | +137.5万股 | 新买入 |
| Bellevue 集团Bellevue Group AG |
| 0.94% | — | #14 | $4,444.2万 | 135.0万股 | $0 | 0股 | +135.0万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | — | #64 | $3,217.2万 | 97.7万股 | $0 | 0股 | +97.7万股 | 新买入 |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 10.34% | — | #5 | $3,182.7万 | 96.7万股 | $0 | 0股 | +96.7万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #47 | $3,157.4万 | 95.9万股 | $0 | 0股 | +95.9万股 | 新买入 |
| Andera Partners |
| 14.82% | — | #2 | $3,061.0万 | 93.0万股 | $0 | 0股 | +93.0万股 | 新买入 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.02% | — | #31 | $2,675.6万 | 81.3万股 | $0 | 0股 | +81.3万股 | 新买入 |
| BRAIDWELL LP |
| 0.98% | — | #13 | $2,638.2万 | 80.1万股 | $0 | 0股 | +80.1万股 | 新买入 |
| TPG集团TPG GP A, LLC |
| 0.51% | — | #17 | $2,544.9万 | 77.3万股 | $0 | 0股 | +77.3万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #62 | $2,435.3万 | 74.0万股 | $0 | 0股 | +74.0万股 | 新买入 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.25% | — | #20 | $2,406.5万 | 73.1万股 | $0 | 0股 | +73.1万股 | 新买入 |
| Rock Springs Capital Management LP |
| 1.07% | — | #12 | $2,182.3万 | 66.3万股 | $0 | 0股 | +66.3万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #59 | $1,431.2万 | 43.5万股 | $0 | 0股 | +43.5万股 | 新买入 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.48% | — | #18 | $1,379.3万 | 41.9万股 | $0 | 0股 | +41.9万股 | 新买入 |
| INFINITUM ASSET MANAGEMENT, LLC |
| 1.38% | — | #9 | $1,354.3万 | 41.1万股 | $0 | 0股 | +41.1万股 | 新买入 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.06% | — | #26 | $1,152.2万 | 35.0万股 | $0 | 0股 | +35.0万股 | 新买入 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | — | #50 | $1,091.9万 | 33.2万股 | $0 | 0股 | +33.2万股 | 新买入 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 1.13% | — | #11 | $1,088.0万 | 33.0万股 | $0 | 0股 | +33.0万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | — | #58 | $934.4万 | 28.4万股 | $0 | 0股 | +28.4万股 | 新买入 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.01% | — | #42 | $526.7万 | 16.0万股 | $0 | 0股 | +16.0万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | — | #32 | $497.1万 | 15.1万股 | $0 | 0股 | +15.1万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #60 | $483.9万 | 14.7万股 | $0 | 0股 | +14.7万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 0.22% | — | #21 | $482.1万 | 14.6万股 | $0 | 0股 | +14.6万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | — | #61 | $449.0万 | 13.6万股 | $0 | 0股 | +13.6万股 | 新买入 |
| STEMPOINT CAPITAL LP |
| 0.55% | — | #16 | $388.5万 | 11.8万股 | $0 | 0股 | +11.8万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #73 | $386.3万 | 11.7万股 | $0 | 0股 | +11.7万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #57 | $384.4万 | 11.7万股 | $0 | 0股 | +11.7万股 | 新买入 |
| ACUTA CAPITAL PARTNERS, LLC |
| 2.64% | — | #7 | $378.6万 | 11.5万股 | $0 | 0股 | +11.5万股 | 新买入 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.14% | — | #23 | $378.6万 | 11.5万股 | $0 | 0股 | +11.5万股 | 新买入 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.05% | — | #27 | $363.6万 | 11.0万股 | $0 | 0股 | +11.0万股 | 新买入 |
| 黑石集团Blackstone Inc. |
| 0.01% | — | #36 | $322.6万 | 9.8万股 | $0 | 0股 | +9.8万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | — | #49 | $311.5万 | 9.5万股 | $0 | 0股 | +9.5万股 | 新买入 |
| SEVEN GRAND MANAGERS, LLC |
| 0.1% | — | #24 | $246.9万 | 7.5万股 | $0 | 0股 | +7.5万股 | 新买入 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| 0.01% | — | #33 | $230.4万 | 7.0万股 | $0 | 0股 | +7.0万股 | 新买入 |
| Atom Investors LP |
| 0.2% | — | #22 | $224.7万 | 6.8万股 | $0 | 0股 | +6.8万股 | 新买入 |
| 安本标准投资Aberdeen Group plc |
| <0.01% | — | #48 | $221.1万 | 6.7万股 | $0 | 0股 | +6.7万股 | 新买入 |
| Zimmer 合伙人Zimmer Partners, LP |
| 0.05% | — | #28 | $205.8万 | 6.3万股 | $0 | 0股 | +6.3万股 | 新买入 |
| Avidity Partners Management LP |
| 0.32% | — | #19 | $197.5万 | 6.0万股 | $0 | 0股 | +6.0万股 | 新买入 |
| LMR合伙人LMR Partners LLP |
| 0.01% | — | #43 | $178.8万 | 5.4万股 | $0 | 0股 | +5.4万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #67 | $164.7万 | 5.0万股 | $0 | 0股 | +5.0万股 | 新买入 |
