| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.61% | 0.49% | #9 | $1.22亿 | 1,104.5万股 | $8,449.7万 | 1,104.5万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #92 | $9,917.1万 | 895.9万股 | $4,773.0万 | 623.9万股 | +271.9万股+43.58% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.7% | 0.56% | #8 | $8,204.6万 | 741.2万股 | $5,628.0万 | 735.7万股 | +5.5万股+0.74% | 加仓 |
| Ridgeback Capital Investments L.P. |
| 100% | — | #1 | $8,092.9万 | 731.1万股 | $0 | 0股 | +731.1万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #56 | $5,038.0万 | 455.1万股 | $1,742.1万 | 227.7万股 | +227.4万股+99.84% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #93 | $4,915.2万 | 444.0万股 | $2,893.4万 | 378.2万股 | +65.8万股+17.39% | 加仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 0.89% | 0.82% | #7 | $4,859.5万 | 439.0万股 | $3,229.7万 | 422.2万股 | +16.8万股+3.98% | 加仓 |
| Boxer Capital Management, LLC |
| 3.32% | 1.18% | #3 | $4,409.2万 | 398.3万股 | $898.9万 | 117.5万股 | +280.8万股+238.98% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.2% | 0.06% | #15 | $4,381.3万 | 395.8万股 | $1,089.7万 | 142.4万股 | +253.3万股+177.85% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #120 | $3,205.9万 | 289.6万股 | $2,110.7万 | 275.9万股 | +13.7万股+4.96% | 加仓 |
| FCPM III SERVICES B.V. |
| 4.14% | 2.97% | #2 | $3,108.9万 | 280.8万股 | $2,148.4万 | 280.8万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #72 | $2,858.0万 | 258.2万股 | $500.5万 | 65.4万股 | +192.8万股+294.61% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #50 | $2,840.8万 | 256.6万股 | $195.5万 | 25.5万股 | +231.1万股+904.42% | 加仓 |
| Logos Global Management LP |
| 1.19% | — | #6 | $2,767.5万 | 250.0万股 | $0 | 0股 | +250.0万股 | 新买入 |
| 奥地利Erste资产管理Erste Asset Management GmbH |
| 0.18% | 0.14% | #16 | $2,374.4万 | 212.0万股 | $1,526.4万 | 212.0万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #100 | $2,253.5万 | 203.5万股 | $1,378.5万 | 180.2万股 | +23.4万股+12.97% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #49 | $2,202.9万 | 199.0万股 | $1,787.4万 | 233.7万股 | -34.7万股-14.83% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #70 | $2,134.6万 | 192.8万股 | $630.2万 | 82.4万股 | +110.4万股+134.06% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #88 | $2,035.4万 | 183.9万股 | $1,775.5万 | 232.1万股 | -48.2万股-20.78% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #84 | $1,794.4万 | 162.1万股 | $6,213.0万 | 812.1万股 | -650.0万股-80.04% | 减仓 |
| Opaleye Management Inc. |
| 1.39% | — | #5 | $1,533.2万 | 138.5万股 | $0 | 0股 | +138.5万股 | 新买入 |
| 多伦多道明银行TORONTO DOMINION BANK |
| 0.02% | 0.02% | #40 | $1,411.4万 | 127.5万股 | $1,217.1万 | 159.1万股 | -31.6万股-19.86% | 减仓 |
| DIADEMA PARTNERS LP |
| 1.64% | 1% | #4 | $1,327.1万 | 119.9万股 | $586.0万 | 76.6万股 | +43.3万股+56.49% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #87 | $1,249.0万 | 112.8万股 | $444.6万 | 58.1万股 | +54.7万股+94.13% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $1,096.4万 | 99.0万股 | $369.8万 | 48.3万股 | +50.7万股+104.88% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.02% | — | #37 | $1,077.7万 | 97.3万股 | $0 | 0股 | +97.3万股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #137 | $1,028.8万 | 92.9万股 | $1,564.8万 | 204.5万股 | -111.6万股-54.56% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #123 | $801.7万 | 72.4万股 | $146.1万 | 19.1万股 | +53.3万股+279.33% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | — | #51 | $800.7万 | 72.3万股 | $0 | 0股 | +72.3万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #142 | $767.2万 | 69.3万股 | $576.3万 | 137.6万股 | -68.3万股-49.62% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #145 | $754.7万 | 68.2万股 | $422.7万 | 55.3万股 | +12.9万股+23.38% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #83 | $750.0万 | 67.8万股 | $44.1万 | 5.8万股 | +62.0万股+1,075.97% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #115 | $736.8万 | 66.6万股 | $450.7万 | 58.9万股 | +7.6万股+12.99% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.33% | 0.76% | #12 | $726.0万 | 65.6万股 | $1,287.5万 | 168.3万股 | -102.7万股-61.03% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #112 | $708.5万 | 64.0万股 | $468.0万 | 61.2万股 | +2.8万股+4.61% | 加仓 |
| Eversept Partners, LP |
| 0.34% | 0.16% | #11 | $653.4万 | 59.0万股 | $295.9万 | 38.7万股 | +20.3万股+52.57% | 加仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.1% | 0.02% | #18 | $603.4万 | 54.5万股 | $116.9万 | 15.3万股 | +39.2万股+256.68% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #105 | $601.1万 | 54.3万股 | $256.0万 | 33.5万股 | +20.8万股+62.26% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #109 | $555.9万 | 50.2万股 | $871.9万 | 114.0万股 | -63.8万股-55.96% | 减仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.04% | 0.04% | #27 | $548.5万 | 49.5万股 | $546.4万 | 71.4万股 | -21.9万股-30.63% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #101 | $541.5万 | 48.9万股 | $363.5万 | 47.5万股 | +1.4万股+2.96% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #91 | $452.6万 | 40.9万股 | $11.9万 | 1.6万股 | +39.3万股+2,522.86% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #157 | $364.6万 | 32.9万股 | $193.9万 | 25.3万股 | +7.6万股+29.96% | 加仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #78 | $340.5万 | 30.8万股 | $80.2万 | 10.5万股 | +20.3万股+193.30% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.04% | — | #28 | $292.2万 | 26.4万股 | $0 | 0股 | +26.4万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #140 | $260.6万 | 23.5万股 | $156.7万 | 20.5万股 | +3.1万股+14.95% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #141 | $238.3万 | 21.5万股 | $151.1万 | 19.8万股 | +1.8万股+8.97% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #54 | $211.9万 | 19.1万股 | $291.5万 | 38.1万股 | -19.0万股-49.76% | 减仓 |
| Creative Planning财富管理Creative Planning |
| <0.01% | <0.01% | #107 | $192.8万 | 17.4万股 | $37.5万 | 4.9万股 | +12.5万股+254.85% | 加仓 |
| 工程师之门Engineers Gate Manager LP |
| 0.02% | 0.01% | #34 | $191.5万 | 17.3万股 | $115.1万 | 15.0万股 | +2.3万股+14.95% | 加仓 |
