| Sanofi |
| 30.86% | 31.44% | #1 | $1.65亿 | 1,219.8万股 | $1.06亿 | 1,219.8万股 | 00.00% | 持仓不变 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 2.19% | 1.75% | #6 | $1.46亿 | 1,078.7万股 | $8,931.3万 | 1,032.6万股 | +46.1万股+4.46% | 加仓 |
| Rubric资本管理Rubric Capital Management LP |
| 1.13% | 0.64% | #8 | $1.23亿 | 910.0万股 | $6,062.0万 | 700.0万股 | +210.0万股+30.00% | 加仓 |
| JOHNSON & JOHNSON |
| 11.23% | 8.82% | #2 | $8,972.1万 | 664.1万股 | $5,751.2万 | 664.1万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #73 | $6,426.9万 | 475.7万股 | $2,743.6万 | 316.8万股 | +158.9万股+50.16% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.08% | 0.05% | #21 | $5,944.4万 | 440.0万股 | $3,464.0万 | 400.0万股 | +40.0万股+10.00% | 加仓 |
| Opaleye Management Inc. |
| 4.34% | 2.42% | #4 | $4,796.1万 | 355.0万股 | $1,838.7万 | 212.3万股 | +142.7万股+67.20% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #35 | $4,014.8万 | 297.2万股 | $3,001.3万 | 346.6万股 | -49.4万股-14.25% | 减仓 |
| 683 Capital Management, LLC |
| 1.53% | 1.11% | #7 | $3,107.3万 | 230.0万股 | $2,121.7万 | 245.0万股 | -15.0万股-6.12% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.06% | 0.01% | #23 | $2,026.7万 | 150.0万股 | $260.1万 | 30.0万股 | +120.0万股+399.51% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #85 | $1,882.2万 | 139.3万股 | $652.4万 | 75.3万股 | +64.0万股+84.93% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #74 | $1,773.5万 | 131.3万股 | $1,022.2万 | 124.2万股 | +7.1万股+5.69% | 加仓 |
| Knoll Capital Management, LLC |
| 9.68% | 5.74% | #3 | $1,688.8万 | 125.0万股 | $1,082.5万 | 125.0万股 | 00.00% | 持仓不变 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.26% | 0.16% | #14 | $1,493.4万 | 110.5万股 | $743.4万 | 85.8万股 | +24.7万股+28.78% | 加仓 |
| Long Focus 资本管理Long Focus Capital Management, LLC |
| 0.38% | 0.12% | #12 | $1,459.5万 | 108.0万股 | $454.4万 | 52.5万股 | +55.6万股+105.87% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.05% | <0.01% | #24 | $1,371.4万 | 101.5万股 | $11.8万 | 1.4万股 | +100.1万股+7,324.16% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | <0.01% | #43 | $1,152.3万 | 85.3万股 | $368.3万 | 42.5万股 | +42.8万股+100.55% | 加仓 |
| HEIGHTS CAPITAL MANAGEMENT, INC |
| 2.65% | — | #5 | $1,148.4万 | 85.0万股 | $0 | 0股 | +85.0万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #82 | $1,147.1万 | 84.9万股 | $506.5万 | 58.5万股 | +26.4万股+45.17% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #90 | $977.5万 | 72.4万股 | $344.0万 | 39.7万股 | +32.6万股+82.13% | 加仓 |
| J. Goldman & Co LP |
| 0.24% | 0.05% | #15 | $925.1万 | 68.5万股 | $178.6万 | 20.6万股 | +47.9万股+232.08% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #72 | $878.8万 | 65.0万股 | $100.5万 | 11.6万股 | +53.4万股+460.79% | 加仓 |
| 奥地利Erste资产管理Erste Asset Management GmbH |
| 0.07% | 0.05% | #22 | $866.8万 | 69.1万股 | $582.2万 | 72.0万股 | -2.9万股-3.96% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #55 | $863.9万 | 63.9万股 | $114.7万 | 13.2万股 | +50.7万股+382.78% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| <0.01% | — | #52 | $642.7万 | 47.6万股 | $0 | 0股 | +47.6万股 | 新买入 |
| PFM Health Sciences, LP |
| 0.53% | — | #10 | $615.1万 | 45.5万股 | $0 | 0股 | +45.5万股 | 新买入 |
| Hennion & Walsh Asset Management, Inc. |
| 0.16% | 0.1% | #17 | $570.1万 | 42.2万股 | $307.2万 | 35.5万股 | +6.7万股+18.95% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $553.7万 | 41.0万股 | $235.4万 | 27.2万股 | +13.8万股+50.75% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.01% | — | #33 | $473.1万 | 35.0万股 | $0 | 0股 | +35.0万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #93 | $442.3万 | 32.7万股 | $382.3万 | 44.1万股 | -11.4万股-25.83% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #109 | $391.4万 | 29.0万股 | $212.1万 | 24.5万股 | +4.5万股+18.28% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #50 | $273.4万 | 20.2万股 | $61.4万 | 7.1万股 | +13.1万股+185.25% | 加仓 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| 0.02% | — | #30 | $270.2万 | 20.0万股 | $0 | 0股 | +20.0万股 | 新买入 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #75 | $265.6万 | 19.7万股 | $96.1万 | 11.1万股 | +8.6万股+77.11% | 加仓 |
| Privium Fund Management B.V. |
| 0.49% | 0.38% | #11 | $264.9万 | 19.6万股 | $183.7万 | 21.2万股 | -1.6万股-7.54% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #126 | $257.3万 | 20.5万股 | $19.7万 | 2.4万股 | +18.1万股+743.18% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #100 | $249.4万 | 18.5万股 | $262.6万 | 30.3万股 | -11.9万股-39.12% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #53 | $219.4万 | 16.2万股 | $16.1万 | 1.9万股 | +14.4万股+773.93% | 加仓 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.04% | — | #27 | $200.0万 | 14.8万股 | $0 | 0股 | +14.8万股 | 新买入 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #63 | $199.0万 | 14.7万股 | $84.1万 | 9.7万股 | +5.0万股+51.62% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #99 | $193.1万 | 14.3万股 | $109.4万 | 12.6万股 | +1.7万股+13.13% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #107 | $192.4万 | 14.2万股 | $86.8万 | 10.0万股 | +4.2万股+42.16% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #101 | $186.9万 | 13.8万股 | $86.7万 | 10.0万股 | +3.8万股+38.22% | 加仓 |
| 威廉·布莱尔BLAIR WILLIAM & CO/IL |
| <0.01% | <0.01% | #48 | $169.5万 | 12.5万股 | $108.6万 | 12.5万股 | +56股+0.04% | 加仓 |
| 沃利昂资本管理Voleon Capital Management LP |
| 0.03% | <0.01% | #28 | $159.1万 | 11.8万股 | $19.4万 | 2.2万股 | +9.5万股+426.81% | 加仓 |
| 瑞士央行Swiss National Bank |
| <0.01% | — | #78 | $150.5万 | 11.1万股 | $0 | 0股 | +11.1万股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #108 | $133.7万 | 9.9万股 | $33.0万 | 3.8万股 | +6.1万股+159.47% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #131 | $127.7万 | 9.5万股 | $81.8万 | 9.4万股 | +105股+0.11% | 加仓 |
| ALPS顾问ALPS ADVISORS INC |
| 0.01% | — | #42 | $125.9万 | 9.3万股 | $0 | 0股 | +9.3万股 | 新买入 |
| Prosight Management, LP |
| 0.21% | 3.73% | #16 | $121.6万 | 9.0万股 | $2,277.6万 | 263.0万股 | -254.0万股-96.58% | 减仓 |
