| 富达投资FMR LLC |
| 0.01% | 0.01% | #39 | $2.99亿 | 717.3万股 | $2.24亿 | 716.9万股 | +3,955股+0.06% | 加仓 |
| TRV GP V, LLC |
| 52.53% | 55.68% | #1 | $2.62亿 | 628.1万股 | $2.23亿 | 713.5万股 | -85.5万股-11.98% | 减仓 |
| ARCH Venture Management, LLC |
| 14.12% | 17.23% | #3 | $1.55亿 | 372.9万股 | $1.17亿 | 372.9万股 | 00.00% | 持仓不变 |
| 资本国际投资者Capital International Investors |
| 0.03% | 0.02% | #35 | $1.22亿 | 292.2万股 | $9,693.6万 | 309.8万股 | -17.6万股-5.68% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #44 | $1.21亿 | 291.0万股 | $9,206.3万 | 294.2万股 | -3.2万股-1.08% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #76 | $1.13亿 | 270.0万股 | $7,841.1万 | 250.6万股 | +19.4万股+7.73% | 加仓 |
| Cormorant Asset Management, LP |
| 5.62% | 4.65% | #5 | $1.11亿 | 265.8万股 | $9,254.1万 | 295.8万股 | -30.0万股-10.14% | 减仓 |
| Sofinnova Investments, Inc. |
| 4.1% | 2.26% | #6 | $7,935.7万 | 190.4万股 | $5,958.9万 | 190.4万股 | 00.00% | 持仓不变 |
| JOHNSON & JOHNSON |
| 9.31% | 8.56% | #4 | $7,436.1万 | 178.5万股 | $5,583.8万 | 178.5万股 | 00.00% | 持仓不变 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.16% | 0.18% | #24 | $6,702.7万 | 160.9万股 | $5,139.3万 | 164.2万股 | -3.4万股-2.07% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.32% | 0.28% | #15 | $6,446.7万 | 154.7万股 | $4,840.8万 | 154.7万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #85 | $5,610.9万 | 134.7万股 | $4,146.2万 | 132.5万股 | +2.1万股+1.62% | 加仓 |
| TRV GP VI, LLC |
| 17.39% | 22.37% | #2 | $4,038.7万 | 96.9万股 | $3,032.7万 | 96.9万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #90 | $3,411.6万 | 81.9万股 | $2,376.6万 | 76.0万股 | +5.9万股+7.79% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #75 | $3,306.8万 | 79.3万股 | $2,258.3万 | 72.2万股 | +7.2万股+9.95% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #59 | $3,281.3万 | 78.7万股 | $2,711.2万 | 86.6万股 | -7.9万股-9.12% | 减仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.48% | 0.41% | #12 | $3,222.5万 | 77.3万股 | $2,108.7万 | 67.4万股 | +9.9万股+14.75% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.71% | 1.26% | #9 | $3,041.9万 | 73.0万股 | $4,494.0万 | 143.6万股 | -70.6万股-49.17% | 减仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | 0.01% | #52 | $2,683.9万 | 64.4万股 | $2,875.1万 | 91.9万股 | -27.5万股-29.90% | 减仓 |
| Siren, L.L.C. |
| 0.54% | 0.56% | #11 | $2,673.0万 | 64.1万股 | $2,007.2万 | 64.1万股 | 00.00% | 持仓不变 |
| 资本世界投资者Capital World Investors |
| <0.01% | <0.01% | #66 | $2,298.8万 | 55.2万股 | $1,679.0万 | 53.7万股 | +1.5万股+2.80% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #48 | $2,169.6万 | 69.3万股 | $2,208.3万 | 72.8万股 | -3.4万股-4.73% | 减仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.01% | 0.01% | #43 | $1,638.5万 | 39.3万股 | $1,941.9万 | 62.1万股 | -22.7万股-36.64% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #65 | $1,508.7万 | 36.2万股 | $702.5万 | 22.4万股 | +13.8万股+61.30% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #99 | $1,499.9万 | 36.0万股 | $1,004.1万 | 32.1万股 | +3.9万股+12.16% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.07% | — | #30 | $1,447.3万 | 34.8万股 | $0 | 0股 | +34.8万股 | 新买入 |
| Sio Capital Management, LLC |
| 2.12% | 1.65% | #7 | $1,282.0万 | 30.8万股 | $1,147.7万 | 36.7万股 | -5.9万股-16.13% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #100 | $1,240.1万 | 29.8万股 | $815.5万 | 27.5万股 | +2.3万股+8.39% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $1,155.5万 | 27.7万股 | $744.7万 | 23.8万股 | +3.9万股+16.52% | 加仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.19% | 0.17% | #22 | $1,045.1万 | 25.1万股 | $805.5万 | 25.7万股 | -6,636股-2.58% | 减仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.38% | 0.39% | #14 | $1,041.8万 | 25.0万股 | $782.3万 | 25.0万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #79 | $1,028.5万 | 24.7万股 | $750.7万 | 24.0万股 | +6,898股+2.88% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.11% | — | #26 | $932.7万 | 22.4万股 | $0 | 0股 | +22.4万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #96 | $896.9万 | 21.5万股 | $537.4万 | 17.2万股 | +4.3万股+25.31% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #53 | $895.2万 | 21.5万股 | $549.0万 | 17.5万股 | +3.9万股+22.45% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #72 | $868.1万 | 20.8万股 | $592.2万 | 18.9万股 | +1.9万股+10.08% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #42 | $689.8万 | 16.6万股 | $607.7万 | 19.4万股 | -2.9万股-14.75% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #69 | $645.5万 | 15.5万股 | $999.9万 | 32.0万股 | -16.5万股-51.52% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #91 | $629.9万 | 15.1万股 | $474.9万 | 15.2万股 | -584股-0.38% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #47 | $625.1万 | 15.0万股 | $469.4万 | 15.0万股 | 00.00% | 持仓不变 |
| Artia Global Partners LP |
| 1.07% | 0.87% | #8 | $577.2万 | 13.9万股 | $433.4万 | 13.9万股 | 00.00% | 持仓不变 |
| 瑞典银行Swedbank AB |
| <0.01% | <0.01% | #54 | $489.2万 | 11.7万股 | $354.2万 | 11.3万股 | +4,200股+3.71% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #89 | $430.7万 | 10.3万股 | $223.7万 | 7.2万股 | +3.2万股+44.54% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.02% | <0.01% | #37 | $425.7万 | 10.2万股 | $34.9万 | 1.1万股 | +9.1万股+816.42% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | — | #40 | $406.4万 | 9.8万股 | $0 | 0股 | +9.8万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #58 | $382.9万 | 9.2万股 | $310.0万 | 9.9万股 | -7,200股-7.27% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #102 | $362.5万 | 8.7万股 | $244.8万 | 7.8万股 | +8,757股+11.19% | 加仓 |
| 保德信金融PRUDENTIAL FINANCIAL INC |
| <0.01% | <0.01% | #55 | $362.0万 | 8.7万股 | $359.3万 | 11.5万股 | -2.8万股-24.33% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #114 | $343.5万 | 8.2万股 | $0 | 0股 | +8.2万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #104 | $342.6万 | 8.2万股 | $226.3万 | 7.2万股 | +9,903股+13.69% | 加仓 |
