| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 3.27% | 3.51% | #6 | $1.50亿 | 503.3万股 | $1.36亿 | 456.7万股 | +46.6万股+10.20% | 加仓 |
| TRV GP IV, LLC |
| 52.63% | 50.04% | #1 | $1.34亿 | 447.4万股 | $1.34亿 | 447.4万股 | 00.00% | 持仓不变 |
| ARCH Venture Management, LLC |
| 11.18% | 18.16% | #3 | $1.23亿 | 412.0万股 | $1.23亿 | 412.0万股 | 00.00% | 持仓不变 |
| 深轨资本Deep Track Capital, LP |
| 1.62% | 1.7% | #12 | $1.11亿 | 373.3万股 | $1.04亿 | 347.8万股 | +25.5万股+7.33% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #76 | $1.05亿 | 350.3万股 | $7,672.7万 | 257.0万股 | +93.2万股+36.27% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.04% | — | #38 | $1.02亿 | 340.8万股 | $0 | 0股 | +340.8万股 | 新买入 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.05% | — | #35 | $7,769.4万 | 260.4万股 | $0 | 0股 | +260.4万股 | 新买入 |
| Logos Global Management LP |
| 2.49% | 1.84% | #8 | $5,774.0万 | 193.5万股 | $3,686.5万 | 123.5万股 | +70.0万股+56.68% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #85 | $5,306.2万 | 177.8万股 | $4,285.4万 | 143.6万股 | +34.3万股+23.86% | 加仓 |
| a16z资本管理a16z Capital Management, L.L.C. |
| 4.05% | 3.94% | #5 | $5,081.1万 | 170.2万股 | $5,081.1万 | 170.2万股 | 00.00% | 持仓不变 |
| Venrock Adviser, LLC |
| 1.45% | 1.78% | #13 | $4,780.5万 | 160.2万股 | $4,782.1万 | 160.2万股 | 00.00% | 持仓不变 |
| Alphabet公司Alphabet Inc. |
| 0.97% | 1.03% | #18 | $4,144.9万 | 138.9万股 | $4,144.9万 | 138.9万股 | 00.00% | 持仓不变 |
| BRAIDWELL LP |
| 1.26% | — | #16 | $3,401.9万 | 114.0万股 | $0 | 0股 | +114.0万股 | 新买入 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.15% | 0.06% | #27 | $3,305.7万 | 110.8万股 | $1,113.4万 | 37.3万股 | +73.5万股+197.00% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #83 | $3,154.0万 | 105.7万股 | $2,579.7万 | 86.4万股 | +19.3万股+22.30% | 加仓 |
| General Catalyst Group Management, LLC |
| 16.4% | 16.85% | #2 | $3,091.2万 | 103.6万股 | $3,092.2万 | 103.6万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #91 | $2,976.6万 | 99.8万股 | $1,900.6万 | 63.7万股 | +36.1万股+56.67% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.17% | 0.14% | #26 | $2,849.4万 | 95.5万股 | $1,898.9万 | 63.6万股 | +31.9万股+50.10% | 加仓 |
| TRV GP V, LLC |
| 5.69% | 7.08% | #4 | $2,837.2万 | 95.1万股 | $2,838.1万 | 95.1万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #77 | $2,799.5万 | 96.4万股 | $169.6万 | 5.8万股 | +90.6万股+1,549.40% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.02% | 0.01% | #45 | $2,729.1万 | 91.5万股 | $927.3万 | 31.1万股 | +60.4万股+194.42% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #68 | $2,610.6万 | 87.5万股 | $2,415.5万 | 80.9万股 | +6.6万股+8.11% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #84 | $2,560.8万 | 85.8万股 | $1,791.3万 | 60.0万股 | +25.8万股+43.02% | 加仓 |
| Casdin Capital, LLC |
| 1.26% | 1.72% | #15 | $2,518.1万 | 84.4万股 | $2,265.2万 | 75.9万股 | +8.5万股+11.20% | 加仓 |
| ArrowMark Colorado Holdings LLC |
| 0.95% | 0.61% | #19 | $2,289.9万 | 76.7万股 | $2,290.6万 | 76.7万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.07% | 0.07% | #32 | $2,196.9万 | 73.6万股 | $1,940.9万 | 65.0万股 | +8.6万股+13.22% | 加仓 |
| BESSEMER GROUP INC |
| 0.02% | 0.02% | #46 | $1,437.7万 | 48.2万股 | $1,438.1万 | 48.2万股 | 00.00% | 持仓不变 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 1.63% | 1.08% | #11 | $1,246.0万 | 41.8万股 | $678.6万 | 22.7万股 | +19.0万股+83.67% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #107 | $1,173.0万 | 39.3万股 | $583.7万 | 19.6万股 | +19.8万股+101.03% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.02% | 0.01% | #48 | $1,145.2万 | 38.4万股 | $675.3万 | 22.6万股 | +15.8万股+69.64% | 加仓 |
| Ikarian Capital, LLC |
| 1.2% | 0.95% | #17 | $1,130.9万 | 37.9万股 | $1,174.3万 | 39.3万股 | -1.4万股-3.66% | 减仓 |
| 高瓴资本Hillhouse Capital Advisors, Ltd. |
| 1.31% | 0.65% | #14 | $1,092.2万 | 36.6万股 | $1,092.6万 | 36.6万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.47% | 0.09% | #22 | $1,012.4万 | 33.9万股 | $149.5万 | 5.0万股 | +28.9万股+577.27% | 加仓 |
| Squadron Capital Management LLC |
| 3.1% | 2.82% | #7 | $999.6万 | 33.5万股 | $768.6万 | 25.8万股 | +7.8万股+30.10% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #101 | $958.5万 | 32.1万股 | $582.3万 | 19.5万股 | +12.6万股+64.66% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #88 | $879.5万 | 29.5万股 | $631.0万 | 21.1万股 | +8.3万股+39.44% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #94 | $874.7万 | 29.3万股 | $834.9万 | 28.0万股 | +1.3万股+4.80% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.04% | — | #39 | $816.6万 | 27.4万股 | $0 | 0股 | +27.4万股 | 新买入 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| 0.02% | <0.01% | #44 | $805.7万 | 27.0万股 | $24.3万 | 8,150股 | +26.2万股+3,212.88% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #87 | $777.5万 | 26.1万股 | $556.5万 | 18.6万股 | +7.4万股+39.76% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.05% | #54 | $740.0万 | 24.8万股 | $3,516.3万 | 117.8万股 | -93.0万股-78.95% | 减仓 |
| Mass General Brigham, Inc |
| 1.98% | 1.53% | #10 | $716.1万 | 24.0万股 | $716.4万 | 24.0万股 | 00.00% | 持仓不变 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #82 | $678.6万 | 22.7万股 | $320.8万 | 10.7万股 | +12.0万股+111.59% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #79 | $656.3万 | 22.0万股 | $450.7万 | 15.1万股 | +6.9万股+45.65% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.05% | — | #34 | $632.6万 | 21.2万股 | $0 | 0股 | +21.2万股 | 新买入 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #65 | $579.6万 | 20.0万股 | $107.9万 | 3.7万股 | +16.3万股+437.56% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #64 | $575.8万 | 19.3万股 | $47.3万 | 1.6万股 | +17.7万股+1,117.75% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.08% | 0.11% | #30 | $563.5万 | 18.9万股 | $849.2万 | 28.4万股 | -9.6万股-33.61% | 减仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.04% | — | #40 | $546.9万 | 18.3万股 | $0 | 0股 | +18.3万股 | 新买入 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.14% | 0.08% | #28 | $526.1万 | 17.6万股 | $250.0万 | 8.4万股 | +9.3万股+110.50% | 加仓 |
