| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.87% | 1.53% | #10 | $2.15亿 | 725.6万股 | $1.44亿 | 725.6万股 | 00.00% | 持仓不变 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.12% | 0.09% | #22 | $1.88亿 | 633.8万股 | $1.31亿 | 660.6万股 | -26.7万股-4.05% | 减仓 |
| Siren, L.L.C. |
| 3.37% | 3.2% | #8 | $1.66亿 | 560.3万股 | $1.15亿 | 580.3万股 | -20.0万股-3.45% | 减仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 3.64% | 3.02% | #6 | $1.56亿 | 525.0万股 | $1.08亿 | 542.5万股 | -17.5万股-3.23% | 减仓 |
| 深轨资本Deep Track Capital, LP |
| 1.77% | 1.32% | #12 | $1.22亿 | 410.0万股 | $8,080.3万 | 406.3万股 | +3.8万股+0.92% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #79 | $1.14亿 | 384.8万股 | $5,656.1万 | 284.4万股 | +100.4万股+35.32% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.04% | — | #32 | $9,395.7万 | 317.1万股 | $0 | 0股 | +317.1万股 | 新买入 |
| Red Tree Management, LLC |
| 63.77% | 56.39% | #1 | $9,392.5万 | 316.4万股 | $6,306.1万 | 317.1万股 | -6,992股-0.22% | 减仓 |
| TPG集团TPG GP A, LLC |
| 1.79% | 1.63% | #11 | $8,938.0万 | 301.0万股 | $5,987.7万 | 301.0万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $6,581.2万 | 221.7万股 | $3,528.9万 | 177.4万股 | +44.2万股+24.94% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #77 | $6,083.2万 | 204.9万股 | $2,823.2万 | 141.9万股 | +63.0万股+44.35% | 加仓 |
| Royalty Pharma Sub-Manager, LLC |
| 25.05% | 27.02% | #3 | $6,061.1万 | 238.8万股 | $4,668.8万 | 238.8万股 | 00.00% | 持仓不变 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #47 | $5,795.2万 | 195.2万股 | $3,225.4万 | 162.2万股 | +33.0万股+20.37% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #59 | $5,653.7万 | 190.4万股 | $2,737.4万 | 137.6万股 | +52.8万股+38.37% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #69 | $5,620.5万 | 189.3万股 | $4,178.7万 | 210.1万股 | -20.8万股-9.89% | 减仓 |
| Omega Fund Management, LLC |
| 29.14% | 29.16% | #2 | $5,410.0万 | 182.2万股 | $4,758.0万 | 239.2万股 | -57.0万股-23.83% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #76 | $3,452.5万 | 116.3万股 | $1,653.1万 | 83.1万股 | +33.2万股+39.92% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #82 | $2,980.8万 | 101.6万股 | $337.8万 | 17.7万股 | +83.9万股+472.67% | 加仓 |
| Jones Hill Capital LP |
| 5.63% | 5.37% | #4 | $2,650.2万 | 89.3万股 | $2,506.4万 | 126.0万股 | -36.8万股-29.16% | 减仓 |
| ACORN CAPITAL ADVISORS, LLC |
| 5.21% | 3.64% | #5 | $1,910.2万 | 64.3万股 | $1,279.7万 | 64.3万股 | -1股-0.00% | 减仓 |
| Aisling Capital Management LP |
| 3.58% | 2.38% | #7 | $1,689.1万 | 56.9万股 | $1,131.6万 | 56.9万股 | 00.00% | 持仓不变 |
| Palo Alto Investors LP |
| 2.39% | 1.67% | #9 | $1,634.2万 | 55.0万股 | $1,094.8万 | 55.0万股 | 00.00% | 持仓不变 |
| Rock Springs Capital Management LP |
| 0.78% | 0.57% | #17 | $1,589.3万 | 53.5万股 | $972.8万 | 48.9万股 | +4.6万股+9.44% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #88 | $1,545.6万 | 52.1万股 | $1,111.8万 | 55.9万股 | -3.8万股-6.87% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | <0.01% | #55 | $1,479.1万 | 49.8万股 | $550.8万 | 27.7万股 | +22.1万股+79.89% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #68 | $1,370.7万 | 46.2万股 | $217.0万 | 10.9万股 | +35.2万股+322.59% | 加仓 |
| NAN FUNG TRINITY (HK) Ltd |
| 1.25% | 0.93% | #14 | $1,270.4万 | 42.8万股 | $851.1万 | 42.8万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #117 | $1,243.7万 | 41.9万股 | $578.7万 | 29.1万股 | +12.8万股+43.99% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #87 | $1,176.7万 | 39.6万股 | $508.3万 | 25.6万股 | +14.1万股+55.08% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.05% | — | #30 | $1,107.5万 | 37.3万股 | $0 | 0股 | +37.3万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #85 | $1,085.1万 | 36.5万股 | $525.1万 | 26.4万股 | +10.1万股+38.45% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.04% | 0.01% | #33 | $1,048.7万 | 35.3万股 | $214.8万 | 10.8万股 | +24.5万股+227.04% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #109 | $1,047.8万 | 35.3万股 | $652.4万 | 32.8万股 | +2.5万股+7.60% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.02% | 0.01% | #43 | $1,016.0万 | 34.2万股 | $798.5万 | 40.1万股 | -5.9万股-14.75% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #75 | $931.5万 | 31.4万股 | $431.1万 | 21.7万股 | +9.7万股+44.74% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #97 | $899.4万 | 30.3万股 | $3,433.5万 | 172.6万股 | -142.3万股-82.45% | 减仓 |
| 清水投资Clearbridge Investments, LLC |
| 0.01% | 0.01% | #53 | $860.4万 | 29.0万股 | $575.3万 | 28.9万股 | +564股+0.20% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #78 | $857.3万 | 28.9万股 | $31.5万 | 1.6万股 | +27.3万股+1,725.45% | 加仓 |
| DAFNA Capital Management LLC |
| 1.61% | 1.91% | #13 | $846.0万 | 28.5万股 | $838.8万 | 42.2万股 | -13.7万股-32.43% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #126 | $842.9万 | 28.4万股 | $157.9万 | 10.0万股 | +18.4万股+183.80% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #67 | $778.6万 | 26.2万股 | $311.7万 | 15.7万股 | +10.6万股+67.36% | 加仓 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #56 | $775.3万 | 26.1万股 | $536.5万 | 27.0万股 | -8,600股-3.19% | 减仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.08% | 0.1% | #26 | $692.5万 | 23.3万股 | $658.0万 | 33.1万股 | -9.8万股-29.50% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | 0.02% | #38 | $690.9万 | 23.3万股 | $462.8万 | 23.3万股 | 00.00% | 持仓不变 |
| SEB资产管理SEB Asset Management AB |
| 0.03% | — | #34 | $689.3万 | 23.2万股 | $0 | 0股 | +23.2万股 | 新买入 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.11% | 0.26% | #24 | $567.4万 | 19.1万股 | $1,327.3万 | 66.7万股 | -47.6万股-71.36% | 减仓 |
| Atle Fund Management AB |
| 1.16% | 0.75% | #15 | $432.5万 | 14.6万股 | $231.5万 | 117.0万股 | -102.4万股-87.55% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #90 | $427.6万 | 14.4万股 | $261.9万 | 13.2万股 | +1.2万股+9.38% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #114 | $358.3万 | 12.1万股 | $165.6万 | 8.3万股 | +3.7万股+44.92% | 加仓 |
| Napean Trading & Investment Co (Singapore) PTE Ltd |
| 1.16% | 0.97% | #16 | $337.8万 | 11.4万股 | $226.3万 | 11.4万股 | 00.00% | 持仓不变 |
