| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #94 | $6,270.6万 | 3,014.7万股 | $4,658.2万 | 1,909.1万股 | +1,105.6万股+57.91% | 加仓 |
| PFIZER INC |
| 27.55% | 20.85% | #1 | $4,692.8万 | 2,203.2万股 | $4,979.2万 | 2,203.2万股 | 00.00% | 持仓不变 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 1.02% | 0.24% | #6 | $4,668.9万 | 2,244.7万股 | $926.4万 | 379.7万股 | +1,865.0万股+491.22% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #88 | $3,957.4万 | 1,902.6万股 | $2,113.1万 | 866.0万股 | +1,036.6万股+119.69% | 加仓 |
| TPG集团TPG GP A, LLC |
| 0.78% | 1.24% | #8 | $3,893.0万 | 1,871.6万股 | $4,566.8万 | 1,871.6万股 | 00.00% | 持仓不变 |
| Sio Capital Management, LLC |
| 4.59% | — | #2 | $2,771.3万 | 1,332.3万股 | $0 | 0股 | +1,332.3万股 | 新买入 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| 0.02% | 0.02% | #30 | $2,729.7万 | 1,312.3万股 | $2,044.7万 | 838.0万股 | +474.4万股+56.61% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #114 | $2,530.7万 | 1,216.7万股 | $1,688.8万 | 692.1万股 | +524.5万股+75.78% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #91 | $2,497.9万 | 1,200.9万股 | $387.9万 | 159.0万股 | +1,041.9万股+655.37% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #71 | $2,126.5万 | 1,022.3万股 | $1,680.5万 | 688.7万股 | +333.6万股+48.44% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #37 | $1,619.1万 | 778.4万股 | $1,311.6万 | 537.5万股 | +240.9万股+44.81% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #102 | $1,466.6万 | 704.9万股 | $1,006.5万 | 412.4万股 | +292.5万股+70.93% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #90 | $1,279.0万 | 614.9万股 | $675.0万 | 276.6万股 | +338.3万股+122.29% | 加仓 |
| GordonMD Global Investments LP |
| 4.36% | 2.43% | #3 | $1,102.0万 | 529.8万股 | $348.9万 | 143.0万股 | +386.8万股+270.49% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.01% | #48 | $1,059.8万 | 509.5万股 | $841.3万 | 344.8万股 | +164.7万股+47.78% | 加仓 |
| Patient Square Capital LP |
| 1.63% | 1.49% | #5 | $1,050.4万 | 505.0万股 | $841.8万 | 345.0万股 | +160.0万股+46.38% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.01% | 0.01% | #32 | $1,040.4万 | 500.2万股 | $356.8万 | 146.2万股 | +354.0万股+242.07% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $1,007.5万 | 484.4万股 | $810.6万 | 332.2万股 | +152.2万股+45.81% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #59 | $979.8万 | 471.1万股 | $674.4万 | 276.4万股 | +194.7万股+70.45% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #93 | $965.0万 | 463.9万股 | $1,313.0万 | 538.1万股 | -74.2万股-13.78% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #117 | $938.1万 | 451.0万股 | $161.1万 | 129.9万股 | +321.1万股+247.14% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | 0.03% | #20 | $936.1万 | 450.1万股 | $854.3万 | 350.1万股 | +100.0万股+28.55% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.04% | 0.02% | #17 | $901.1万 | 433.6万股 | $315.9万 | 230.6万股 | +203.1万股+88.07% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #124 | $876.1万 | 421.2万股 | $413.4万 | 169.4万股 | +251.8万股+148.63% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #38 | $797.5万 | 383.4万股 | $522.0万 | 213.9万股 | +169.5万股+79.23% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| 0.01% | <0.01% | #35 | $753.3万 | 362.2万股 | $4.7万 | 2.0万股 | +360.2万股+18,372.73% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.02% | — | #23 | $679.7万 | 326.8万股 | $0 | 0股 | +326.8万股 | 新买入 |
| RTW投资RTW INVESTMENTS, LP |
| 0.06% | — | #14 | $676.0万 | 325.0万股 | $0 | 0股 | +325.0万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #85 | $674.0万 | 323.9万股 | $292.7万 | 120.2万股 | +203.7万股+169.55% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #120 | $663.0万 | 318.7万股 | $520.8万 | 213.4万股 | +105.3万股+49.33% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #100 | $632.0万 | 303.8万股 | $391.4万 | 160.4万股 | +143.4万股+89.42% | 加仓 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| 0.04% | — | #19 | $624.0万 | 300.0万股 | $0 | 0股 | +300.0万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #104 | $614.7万 | 295.5万股 | $313.7万 | 128.6万股 | +167.0万股+129.86% | 加仓 |
| Wildcat Capital Management, LLC |
| 2.66% | 6.71% | #4 | $607.5万 | 292.1万股 | $712.7万 | 292.1万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #108 | $473.1万 | 227.4万股 | $340.8万 | 139.7万股 | +87.8万股+62.86% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #80 | $417.3万 | 200.6万股 | $606.3万 | 248.5万股 | -47.8万股-19.26% | 减仓 |
| DAFNA Capital Management LLC |
| 0.79% | 0.76% | #7 | $416.0万 | 200.0万股 | $334.3万 | 137.0万股 | +63.0万股+45.97% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #96 | $382.4万 | 183.8万股 | $266.4万 | 109.2万股 | +74.7万股+68.38% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #151 | $319.3万 | 143.8万股 | $318.5万 | 143.5万股 | +3,787股+0.26% | 加仓 |
| Boxer Capital Management, LLC |
| 0.23% | 0.87% | #10 | $312.0万 | 150.0万股 | $664.9万 | 272.5万股 | -122.5万股-44.95% | 减仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | 0.02% | #39 | $302.7万 | 145.5万股 | $491.3万 | 201.4万股 | -55.8万股-27.73% | 减仓 |
| 赖夫艾森国际银行Raiffeisen Bank International AG |
| 0.03% | 0.02% | #21 | $244.6万 | 110.2万股 | $155.9万 | 70.2万股 | +40.0万股+56.98% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #161 | $160.7万 | 77.3万股 | $167.0万 | 68.5万股 | +8.8万股+12.89% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #137 | $151.3万 | 72.7万股 | $96.4万 | 39.5万股 | +33.2万股+84.01% | 加仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.04% | — | #16 | $150.4万 | 72.3万股 | $0 | 0股 | +72.3万股 | 新买入 |
| 英仕曼集团Man Group plc |
| <0.01% | <0.01% | #72 | $146.0万 | 70.2万股 | $37.7万 | 15.5万股 | +54.7万股+353.77% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | — | #126 | $141.2万 | 67.9万股 | $0 | 0股 | +67.9万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #130 | $129.9万 | 62.5万股 | $564.9万 | 231.5万股 | -169.0万股-73.02% | 减仓 |
| IEQ资本IEQ CAPITAL, LLC |
| 0.01% | 0.01% | #57 | $120.7万 | 58.0万股 | $149.9万 | 61.4万股 | -3.4万股-5.51% | 减仓 |
| 三菱UFJ资产管理Mitsubishi UFJ Asset Management Co., Ltd. |
| <0.01% | <0.01% | #107 | $113.8万 | 54.7万股 | $104.6万 | 42.9万股 | +11.8万股+27.64% | 加仓 |
