| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 8% | 5.11% | #3 | $3.67亿 | 665.2万股 | $1.99亿 | 665.2万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| 0.01% | <0.01% | #50 | $2.94亿 | 532.3万股 | $8,766.0万 | 293.7万股 | +238.6万股+81.25% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.05% | 0.02% | #44 | $2.75亿 | 497.8万股 | $9,527.6万 | 319.2万股 | +178.6万股+55.95% | 加仓 |
| NEA Management Company, LLC |
| 12.56% | 6.13% | #2 | $2.00亿 | 361.4万股 | $1.08亿 | 361.4万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 3.57% | 2.15% | #6 | $1.89亿 | 342.9万股 | $1.09亿 | 363.8万股 | -20.9万股-5.75% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #75 | $1.83亿 | 332.4万股 | $8,780.1万 | 294.1万股 | +38.2万股+13.00% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 2.59% | — | #9 | $1.38亿 | 250.8万股 | $0 | 0股 | +250.8万股 | 新买入 |
| NVP Associates, LLC |
| 35.93% | 36.2% | #1 | $1.18亿 | 213.6万股 | $6,377.0万 | 213.6万股 | 00.00% | 持仓不变 |
| 深轨资本Deep Track Capital, LP |
| 1.39% | 1.34% | #13 | $9,563.8万 | 173.3万股 | $8,231.3万 | 275.8万股 | -102.5万股-37.17% | 减仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.21% | 0.17% | #30 | $8,879.0万 | 160.9万股 | $4,842.2万 | 162.2万股 | -1.4万股-0.84% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #85 | $8,155.2万 | 147.7万股 | $4,410.6万 | 147.8万股 | -204股-0.01% | 减仓 |
| Aaron Wealth Advisors LLC |
| 3.27% | 1.98% | #7 | $6,446.3万 | 116.8万股 | $3,487.0万 | 116.8万股 | -377股-0.03% | 减仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.34% | 0.22% | #24 | $5,832.3万 | 105.7万股 | $3,039.4万 | 101.8万股 | +3.8万股+3.77% | 加仓 |
| Kynam Capital Management, LP |
| 2.85% | 1.72% | #8 | $5,160.1万 | 93.5万股 | $2,790.4万 | 93.5万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.15% | 0.1% | #34 | $4,968.5万 | 90.0万股 | $2,686.7万 | 90.0万股 | +29股+0.00% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.64% | 0.44% | #20 | $4,821.7万 | 87.3万股 | $2,656.7万 | 89.0万股 | -1.7万股-1.85% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #91 | $4,771.9万 | 86.4万股 | $2,349.8万 | 78.7万股 | +7.7万股+9.81% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #65 | $4,497.7万 | 81.5万股 | $3,071.7万 | 102.9万股 | -21.4万股-20.82% | 减仓 |
| Parkman Healthcare Partners LLC |
| 4.52% | 2.46% | #5 | $4,417.0万 | 80.0万股 | $2,388.1万 | 80.0万股 | +136股+0.02% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #78 | $4,268.3万 | 77.3万股 | $2,001.6万 | 67.0万股 | +10.3万股+15.32% | 加仓 |
| BRAIDWELL LP |
| 1.45% | 1.49% | #12 | $3,924.1万 | 71.1万股 | $4,455.0万 | 149.2万股 | -78.2万股-52.37% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.86% | 0.56% | #18 | $3,588.0万 | 65.0万股 | $1,940.3万 | 65.0万股 | 00.00% | 持仓不变 |
| Cormorant Asset Management, LP |
| 1.54% | 1.68% | #11 | $3,036.0万 | 55.0万股 | $3,343.2万 | 112.0万股 | -57.0万股-50.89% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.98% | 0.22% | #17 | $2,844.3万 | 51.5万股 | $534.0万 | 17.9万股 | +33.6万股+188.03% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #80 | $2,533.7万 | 45.9万股 | $1,367.0万 | 45.8万股 | +1,060股+0.23% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.02% | <0.01% | #48 | $2,218.4万 | 40.2万股 | $187.2万 | 6.3万股 | +33.9万股+540.93% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.1% | — | #38 | $2,208.0万 | 40.0万股 | $0 | 0股 | +40.0万股 | 新买入 |
| EcoR1 Capital, LLC |
| 1.04% | 0.98% | #16 | $2,144.5万 | 38.9万股 | $2,319.3万 | 77.7万股 | -38.9万股-50.00% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #106 | $1,913.9万 | 34.7万股 | $875.5万 | 29.3万股 | +5.3万股+18.21% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #100 | $1,650.1万 | 29.9万股 | $85.8万 | 2.9万股 | +27.0万股+939.75% | 加仓 |
| Rock Springs Capital Management LP |
| 0.8% | 0.51% | #19 | $1,646.2万 | 29.8万股 | $859.6万 | 28.8万股 | +1.0万股+3.56% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.07% | — | #39 | $1,598.7万 | 29.0万股 | $0 | 0股 | +29.0万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #82 | $1,505.6万 | 27.3万股 | $1,035.5万 | 34.7万股 | -7.4万股-21.38% | 减仓 |
| Opaleye Management Inc. |
| 1.3% | 1.02% | #14 | $1,435.2万 | 26.0万股 | $776.1万 | 26.0万股 | 00.00% | 持仓不变 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | — | #73 | $1,394.7万 | 25.3万股 | $0 | 0股 | +25.3万股 | 新买入 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.05% | 0.03% | #43 | $1,372.7万 | 24.9万股 | $369.6万 | 12.4万股 | +12.5万股+100.84% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #113 | $1,372.0万 | 24.9万股 | $78.5万 | 4.5万股 | +20.4万股+453.98% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #88 | $1,361.7万 | 24.7万股 | $628.6万 | 21.1万股 | +3.6万股+17.14% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #77 | $1,290.0万 | 23.4万股 | $139.6万 | 4.7万股 | +18.7万股+399.86% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #86 | $1,286.7万 | 23.3万股 | $641.5万 | 21.5万股 | +1.8万股+8.46% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #66 | $1,248.4万 | 22.6万股 | $1,684.8万 | 56.4万股 | -33.8万股-59.93% | 减仓 |
| Tetragon Partners GP Ltd |
| 1.77% | 0.84% | #10 | $1,123.6万 | 20.4万股 | $434.3万 | 14.5万股 | +5.8万股+39.91% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #76 | $1,111.9万 | 20.1万股 | $507.9万 | 17.0万股 | +3.1万股+18.38% | 加仓 |
| Caligan Partners LP |
| 0.52% | 1.69% | #23 | $1,104.0万 | 20.0万股 | $2,533.0万 | 84.9万股 | -64.9万股-76.43% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | 0.01% | #60 | $1,008.9万 | 18.3万股 | $862.3万 | 28.9万股 | -10.6万股-36.73% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #114 | $839.5万 | 15.2万股 | $305.6万 | 10.2万股 | +5.0万股+48.54% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #128 | $751.8万 | 14.0万股 | $395.9万 | 14.7万股 | -7,446股-5.06% | 减仓 |
| KVP Capital Advisors, LP |
| 4.92% | 2.71% | #4 | $670.8万 | 12.2万股 | $362.7万 | 12.2万股 | 00.00% | 持仓不变 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #64 | $626.4万 | 11.3万股 | $343.5万 | 11.5万股 | -1,600股-1.39% | 减仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.2% | 0.15% | #31 | $552.0万 | 10.0万股 | $298.5万 | 10.0万股 | 00.00% | 持仓不变 |
