| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #54 | $2.20亿 | 1,365.1万股 | $1.57亿 | 1,303.6万股 | +61.5万股+4.72% | 加仓 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| 0.1% | 0.1% | #16 | $1.64亿 | 1,018.1万股 | $1.25亿 | 1,033.8万股 | -15.7万股-1.52% | 减仓 |
| BVF INC/IL |
| 2.94% | 2.74% | #1 | $1.15亿 | 713.4万股 | $8,603.3万 | 713.4万股 | 00.00% | 持仓不变 |
| RTW投资RTW INVESTMENTS, LP |
| 0.93% | 0.81% | #6 | $1.09亿 | 677.7万股 | $8,173.6万 | 677.7万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.74% | 0.63% | #7 | $8,491.6万 | 527.4万股 | $5,906.1万 | 489.7万股 | +37.7万股+7.70% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #66 | $7,976.0万 | 495.4万股 | $5,248.6万 | 435.2万股 | +60.2万股+13.83% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #97 | $5,278.9万 | 327.9万股 | $3,740.6万 | 310.2万股 | +17.7万股+5.71% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.95% | 0.85% | #5 | $3,947.9万 | 245.2万股 | $2,957.3万 | 245.2万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #50 | $3,793.8万 | 235.6万股 | $1,882.0万 | 156.0万股 | +79.6万股+51.01% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #81 | $3,567.3万 | 221.6万股 | $4,221.4万 | 350.0万股 | -128.5万股-36.70% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #78 | $3,093.3万 | 192.1万股 | $2,190.1万 | 181.6万股 | +10.5万股+5.80% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #85 | $2,821.6万 | 175.3万股 | $1,056.7万 | 90.1万股 | +85.2万股+94.55% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #62 | $2,102.9万 | 130.6万股 | $1,305.4万 | 108.2万股 | +22.4万股+20.67% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.09% | 0.08% | #17 | $1,774.4万 | 110.2万股 | $1,329.1万 | 110.2万股 | 00.00% | 持仓不变 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | <0.01% | #51 | $1,756.8万 | 109.1万股 | $1,286.5万 | 106.7万股 | +2.4万股+2.29% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #58 | $1,627.6万 | 101.1万股 | $1,561.3万 | 129.5万股 | -28.4万股-21.91% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #89 | $1,559.7万 | 96.9万股 | $921.1万 | 76.4万股 | +20.5万股+26.84% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #49 | $1,374.4万 | 85.4万股 | $735.4万 | 61.0万股 | +24.4万股+40.00% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #37 | $1,319.4万 | 82.0万股 | $971.3万 | 80.5万股 | +1.4万股+1.75% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #86 | $1,278.8万 | 79.4万股 | $897.9万 | 74.5万股 | +5.0万股+6.68% | 加仓 |
| JOHNSON & JOHNSON |
| 1.51% | 1.38% | #3 | $1,204.4万 | 74.8万股 | $902.2万 | 74.8万股 | 00.00% | 持仓不变 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.08% | 0.06% | #18 | $1,159.9万 | 72.0万股 | $868.9万 | 72.0万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #82 | $1,138.7万 | 70.7万股 | $840.4万 | 69.7万股 | +1.0万股+1.49% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.03% | 0.03% | #26 | $1,095.1万 | 68.0万股 | $748.6万 | 62.1万股 | +5.9万股+9.57% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.14% | — | #11 | $955.6万 | 59.4万股 | $0 | 0股 | +59.4万股 | 新买入 |
| 多伦多道明银行TORONTO DOMINION BANK |
| 0.01% | 0.01% | #39 | $790.5万 | 49.1万股 | $592.1万 | 49.1万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #76 | $784.2万 | 48.7万股 | $568.1万 | 47.1万股 | +1.6万股+3.40% | 加仓 |
| Seven Fleet Capital Management LP |
| 1.29% | 0.31% | #4 | $782.9万 | 36.8万股 | $96.5万 | 8.0万股 | +28.8万股+360.38% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $779.0万 | 48.4万股 | $195.9万 | 16.2万股 | +32.1万股+197.90% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #99 | $661.3万 | 41.1万股 | $477.5万 | 39.6万股 | +1.5万股+3.75% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #98 | $615.2万 | 38.2万股 | $146.3万 | 12.1万股 | +26.1万股+214.89% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #143 | $580.2万 | 36.0万股 | $441.5万 | 36.6万股 | -5,697股-1.56% | 减仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| <0.01% | <0.01% | #60 | $576.7万 | 35.8万股 | $418.6万 | 34.7万股 | +1.1万股+3.21% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #149 | $419.6万 | 26.1万股 | $318.2万 | 26.4万股 | -3,232股-1.22% | 减仓 |
| Velan Capital Investment Management LP |
| 2.5% | 1.89% | #2 | $410.6万 | 25.5万股 | $301.5万 | 25.0万股 | +5,000股+2.00% | 加仓 |
| 加拿大公共部门养老金投资委员会(PSP)PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.01% | 0.01% | #36 | $410.1万 | 25.5万股 | $308.1万 | 25.5万股 | -731股-0.29% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.17% | 0.07% | #10 | $374.4万 | 23.3万股 | $113.0万 | 9.4万股 | +13.9万股+148.29% | 加仓 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| 0.01% | 0.02% | #38 | $338.1万 | 21.0万股 | $587.7万 | 48.7万股 | -27.7万股-56.91% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #120 | $327.8万 | 20.4万股 | $263.3万 | 21.8万股 | -1.5万股-6.75% | 减仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | <0.01% | #48 | $322.0万 | 20.0万股 | $241.2万 | 20.0万股 | 00.00% | 持仓不变 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #145 | $307.2万 | 19.1万股 | $455.5万 | 37.8万股 | -18.7万股-49.48% | 减仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #68 | $292.4万 | 18.2万股 | $205.6万 | 17.0万股 | +1.1万股+6.54% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #94 | $290.1万 | 18.0万股 | $211.3万 | 17.5万股 | +5,028股+2.87% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #102 | $269.2万 | 16.7万股 | $125.8万 | 10.4万股 | +6.3万股+60.30% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #174 | $260.7万 | 16.7万股 | $229.1万 | 20.2万股 | -3.5万股-17.24% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.04% | 0.02% | #24 | $256.9万 | 16.0万股 | $166.6万 | 13.8万股 | +2.1万股+15.54% | 加仓 |
| KORNITZER CAPITAL MANAGEMENT INC /KS |
| 0.05% | — | #23 | $243.8万 | 15.1万股 | $0 | 0股 | +15.1万股 | 新买入 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | <0.01% | #32 | $232.7万 | 14.5万股 | $53.7万 | 4.4万股 | +10.0万股+224.91% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #127 | $224.4万 | 13.9万股 | $162.5万 | 13.5万股 | +4,592股+3.41% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| 0.02% | <0.01% | #31 | $210.9万 | 13.1万股 | $12.7万 | 1.1万股 | +12.0万股+1,143.95% | 加仓 |
