| Trium Capital LLP |
| 6.76% | 2.97% | #8 | $109.82亿 | 39.0万股 | $421.6万 | 19.1万股 | +19.9万股+103.91% | 加仓 |
| AyurMaya Capital Management Company, LP |
| 100% | — | #1 | $4.26亿 | 1,514.0万股 | $0 | 0股 | +1,514.0万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #85 | $2.31亿 | 821.8万股 | $1.58亿 | 717.1万股 | +104.7万股+14.60% | 加仓 |
| 富达投资FMR LLC |
| 0.01% | <0.01% | #63 | $1.90亿 | 676.9万股 | $2,145.2万 | 97.4万股 | +579.5万股+595.14% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 2.6% | 2.44% | #19 | $1.79亿 | 634.9万股 | $1.49亿 | 677.3万股 | -42.4万股-6.26% | 减仓 |
| Samsara BioCapital, LLC |
| 14.67% | 13.58% | #5 | $1.79亿 | 634.5万股 | $1.40亿 | 634.5万股 | 00.00% | 持仓不变 |
| Foresite Capital Management V, LLC |
| 45.81% | 47.94% | #2 | $1.66亿 | 589.7万股 | $1.30亿 | 589.7万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #58 | $1.46亿 | 520.0万股 | $7,240.8万 | 328.7万股 | +191.3万股+58.21% | 加仓 |
| venBio Partners LLC |
| 24.53% | 35.56% | #3 | $1.27亿 | 452.8万股 | $9,976.1万 | 452.8万股 | 00.00% | 持仓不变 |
| Foresite Capital Management VI LLC |
| 18.6% | 20.33% | #4 | $1.20亿 | 424.8万股 | $9,357.6万 | 424.8万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #99 | $1.19亿 | 421.6万股 | $8,883.1万 | 403.2万股 | +18.3万股+4.55% | 加仓 |
| Nextech Invest Ltd. |
| 4.75% | 5.49% | #11 | $9,964.4万 | 354.1万股 | $7,800.8万 | 354.1万股 | 00.00% | 持仓不变 |
| Cormorant Asset Management, LP |
| 4.69% | 4.37% | #12 | $9,245.7万 | 328.6万股 | $8,700.2万 | 394.9万股 | -66.4万股-16.80% | 减仓 |
| Saturn V Capital Management LP |
| 11.76% | 12.77% | #6 | $8,204.1万 | 291.5万股 | $7,054.2万 | 320.2万股 | -28.7万股-8.95% | 减仓 |
| Octagon Capital Advisors LP |
| 7.16% | 6.9% | #7 | $7,965.6万 | 283.1万股 | $6,236.0万 | 283.1万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| 0.03% | — | #49 | $6,623.8万 | 235.5万股 | $0 | 0股 | +235.5万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #113 | $6,155.0万 | 218.7万股 | $3,969.4万 | 180.2万股 | +38.5万股+21.39% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #89 | $6,103.4万 | 216.9万股 | $4,227.4万 | 191.8万股 | +25.0万股+13.04% | 加仓 |
| MPM BioImpact LLC |
| 3.46% | 4.06% | #18 | $5,681.5万 | 201.9万股 | $5,257.5万 | 238.7万股 | -36.8万股-15.40% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.28% | 0.25% | #34 | $5,663.2万 | 201.3万股 | $4,433.5万 | 201.3万股 | 00.00% | 持仓不变 |
| SR ONE CAPITAL MANAGEMENT, LP |
| 5.31% | 4.72% | #10 | $5,515.1万 | 196.0万股 | $4,317.7万 | 196.0万股 | 00.00% | 持仓不变 |
| Ikarian Capital, LLC |
| 3.66% | 2.64% | #15 | $3,452.4万 | 122.7万股 | $3,256.4万 | 147.8万股 | -25.1万股-17.00% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #96 | $3,302.3万 | 117.4万股 | $3,329.9万 | 151.2万股 | -33.8万股-22.36% | 减仓 |
| Novo Holdings A/S |
| 1.8% | — | #22 | $3,095.4万 | 110.0万股 | $0 | 0股 | +110.0万股 | 新买入 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | 0.01% | #57 | $3,005.5万 | 106.8万股 | $2,330.9万 | 105.8万股 | +1.0万股+0.95% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #60 | $2,724.6万 | 96.8万股 | $1,260.4万 | 57.2万股 | +39.6万股+69.23% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | 0.01% | #86 | $2,678.4万 | 95.2万股 | $6,729.9万 | 305.5万股 | -210.3万股-68.84% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #122 | $2,640.7万 | 97.0万股 | $1,741.2万 | 86.2万股 | +10.8万股+12.54% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #129 | $2,592.3万 | 92.1万股 | $1,569.9万 | 71.3万股 | +20.9万股+29.27% | 加仓 |
| GREAT POINT PARTNERS LLC |
| 4.55% | 4.33% | #13 | $2,409.0万 | 85.6万股 | $1,885.9万 | 85.6万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #111 | $2,341.0万 | 83.2万股 | $1,581.8万 | 71.8万股 | +11.4万股+15.86% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #103 | $2,036.9万 | 72.4万股 | $1,241.4万 | 56.4万股 | +16.0万股+28.45% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #95 | $1,970.2万 | 70.0万股 | $1,399.8万 | 63.5万股 | +6.5万股+10.19% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.78% | 0.84% | #28 | $1,969.8万 | 70.0万股 | $1,762.4万 | 80.0万股 | -10.0万股-12.50% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #67 | $1,857.6万 | 66.0万股 | $1,335.6万 | 60.6万股 | +5.4万股+8.88% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #82 | $1,722.2万 | 61.2万股 | $1,161.7万 | 52.7万股 | +8.5万股+16.06% | 加仓 |
| Opaleye Management Inc. |
| 1.4% | 1.6% | #24 | $1,547.7万 | 55.0万股 | $1,211.7万 | 55.0万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.29% | 0.24% | #33 | $1,542.5万 | 54.8万股 | $1,207.6万 | 54.8万股 | 00.00% | 持仓不变 |
| Royce联营ROYCE & ASSOCIATES LP |
| 0.12% | 0.1% | #36 | $1,478.2万 | 52.5万股 | $1,049.5万 | 47.6万股 | +4.9万股+10.27% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.04% | — | #45 | $1,367.8万 | 48.6万股 | $0 | 0股 | +48.6万股 | 新买入 |
| Spruce Street Capital LP |
| 2.17% | 2.08% | #20 | $1,104.7万 | 39.3万股 | $864.8万 | 39.3万股 | 00.00% | 持仓不变 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #84 | $1,084.5万 | 38.5万股 | $217.9万 | 9.9万股 | +28.6万股+289.59% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #65 | $1,058.4万 | 37.6万股 | $1,449.8万 | 65.8万股 | -28.2万股-42.85% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.03% | #64 | $1,035.6万 | 36.8万股 | $2,583.6万 | 117.3万股 | -80.5万股-68.62% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.13% | 0.12% | #35 | $976.8万 | 34.7万股 | $932.4万 | 42.3万股 | -7.6万股-17.98% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #156 | $903.8万 | 32.1万股 | $132.6万 | 33.2万股 | -1.1万股-3.38% | 减仓 |
| Voloridge投资管理VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.04% | 0.07% | #46 | $902.9万 | 32.1万股 | $1,650.3万 | 74.9万股 | -42.8万股-57.17% | 减仓 |
| 韦斯资产管理Weiss Asset Management LP |
| 0.09% | 0.41% | #40 | $876.2万 | 31.1万股 | $2,417.6万 | 109.7万股 | -78.6万股-71.63% | 减仓 |
| Artia Global Partners LP |
| 1.45% | 1.43% | #23 | $783.8万 | 27.9万股 | $716.1万 | 32.5万股 | -4.7万股-14.31% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #121 | $770.2万 | 27.4万股 | $490.5万 | 22.3万股 | +5.1万股+22.93% | 加仓 |
