| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 3.79% | 4.21% | #6 | $4.36亿 | 990.5万股 | $3.97亿 | 990.5万股 | 00.00% | 持仓不变 |
| TPG集团TPG GP A, LLC |
| 5.71% | 7.08% | #4 | $2.86亿 | 649.5万股 | $2.60亿 | 649.5万股 | 00.00% | 持仓不变 |
| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 0.4% | 0.36% | #18 | $1.41亿 | 319.5万股 | $1.28亿 | 319.5万股 | 00.00% | 持仓不变 |
| Atlas Venture Life Science Advisors, LLC |
| 14.95% | 15.2% | #2 | $1.32亿 | 299.6万股 | $1.20亿 | 299.6万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 2.12% | 2.81% | #8 | $1.12亿 | 255.6万股 | $1.42亿 | 353.1万股 | -97.5万股-27.61% | 减仓 |
| Enavate Sciences GP, LLC |
| 31.56% | 28.26% | #1 | $1.09亿 | 247.8万股 | $9,934.4万 | 247.8万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.1% | 0.01% | #30 | $7,038.4万 | 160.0万股 | $601.4万 | 15.0万股 | +145.0万股+966.67% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #87 | $6,487.5万 | 147.5万股 | $5,195.1万 | 129.6万股 | +17.9万股+13.81% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #62 | $6,408.6万 | 149.1万股 | $5,370.7万 | 146.5万股 | +2.5万股+1.74% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.03% | 0.04% | #37 | $5,156.2万 | 117.2万股 | $5,817.9万 | 145.1万股 | -27.9万股-19.23% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #57 | $5,085.4万 | 115.6万股 | $4,678.2万 | 116.7万股 | -1.1万股-0.93% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $4,979.7万 | 113.2万股 | $4,127.3万 | 102.9万股 | +10.3万股+9.96% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #81 | $4,493.7万 | 102.2万股 | $3,031.7万 | 75.6万股 | +26.5万股+35.08% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.6% | 0.52% | #13 | $3,981.1万 | 90.5万股 | $2,639.7万 | 65.8万股 | +24.7万股+37.45% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.31% | 0.46% | #21 | $2,995.3万 | 68.1万股 | $3,891.1万 | 97.1万股 | -29.0万股-29.85% | 减仓 |
| Siren, L.L.C. |
| 0.54% | 0.33% | #14 | $2,685.7万 | 61.1万股 | $1,202.7万 | 30.0万股 | +31.1万股+103.51% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #71 | $2,102.8万 | 47.8万股 | $3,032.4万 | 75.6万股 | -27.8万股-36.80% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.28% | 0.43% | #22 | $2,089.4万 | 47.5万股 | $2,587.6万 | 64.6万股 | -17.1万股-26.42% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #85 | $2,011.4万 | 45.7万股 | $1,563.4万 | 39.0万股 | +6.7万股+17.26% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.09% | 0.09% | #34 | $1,759.6万 | 40.0万股 | $1,603.6万 | 40.0万股 | 00.00% | 持仓不变 |
| Casdin Capital, LLC |
| 0.88% | — | #12 | $1,759.6万 | 40.0万股 | $0 | 0股 | +40.0万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #77 | $1,710.4万 | 38.9万股 | $1,055.1万 | 26.3万股 | +12.6万股+47.74% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.1% | 0.02% | #31 | $1,695.6万 | 38.5万股 | $307.2万 | 7.7万股 | +30.9万股+402.98% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $1,431.1万 | 32.5万股 | $563.8万 | 14.1万股 | +18.5万股+131.32% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #65 | $1,276.2万 | 29.0万股 | $703.5万 | 17.5万股 | +11.5万股+65.32% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.02% | 0.04% | #43 | $1,249.9万 | 28.4万股 | $2,261.8万 | 56.4万股 | -28.0万股-49.64% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #100 | $1,224.2万 | 27.8万股 | $326.3万 | 8.1万股 | +19.7万股+241.90% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.05% | — | #36 | $1,024.9万 | 23.3万股 | $0 | 0股 | +23.3万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #102 | $980.8万 | 22.3万股 | $569.6万 | 14.2万股 | +8.1万股+56.92% | 加仓 |
| Kalehua Capital Management LLC |
| 6.21% | 5.59% | #3 | $866.9万 | 19.7万股 | $790.1万 | 19.7万股 | 00.00% | 持仓不变 |
| Longaeva 合伙人Longaeva Partners L.P. |
| 0.19% | 0.02% | #26 | $863.8万 | 19.6万股 | $50.9万 | 1.3万股 | +18.4万股+1,446.93% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.01% | — | #49 | $833.6万 | 18.9万股 | $0 | 0股 | +18.9万股 | 新买入 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | 0.02% | #48 | $811.8万 | 18.5万股 | $1,024.8万 | 25.6万股 | -7.1万股-27.81% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.27% | 0.48% | #23 | $781.6万 | 17.8万股 | $1,176.6万 | 29.4万股 | -11.6万股-39.46% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #89 | $679.5万 | 15.4万股 | $468.2万 | 11.7万股 | +3.8万股+32.28% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #110 | $664.5万 | 15.1万股 | $67.2万 | 2.3万股 | +12.8万股+561.41% | 加仓 |
| Sofinnova Investments, Inc. |
| 0.33% | — | #20 | $635.4万 | 14.4万股 | $0 | 0股 | +14.4万股 | 新买入 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #58 | $617.2万 | 14.0万股 | $169.3万 | 4.2万股 | +9.8万股+232.16% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.02% | 0.02% | #45 | $599.2万 | 13.6万股 | $546.1万 | 13.6万股 | 00.00% | 持仓不变 |
| GordonMD Global Investments LP |
| 2.37% | 3.8% | #7 | $598.3万 | 13.6万股 | $545.2万 | 13.6万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #90 | $570.8万 | 13.0万股 | $482.1万 | 12.0万股 | +9,500股+7.90% | 加仓 |
| Sio Capital Management, LLC |
| 0.93% | 1.69% | #11 | $562.2万 | 12.8万股 | $1,180.0万 | 29.4万股 | -16.7万股-56.58% | 减仓 |
| Ishara Investments LP |
| 3.91% | 1.87% | #5 | $541.2万 | 12.3万股 | $197.2万 | 4.9万股 | +7.4万股+150.00% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #84 | $534.2万 | 12.1万股 | $449.7万 | 11.2万股 | +9,267股+8.26% | 加仓 |
| Artia Global Partners LP |
| 0.97% | 0.96% | #10 | $526.7万 | 12.0万股 | $480.0万 | 12.0万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #95 | $511.2万 | 11.6万股 | $591.9万 | 14.8万股 | -3.1万股-21.29% | 减仓 |
| First Turn Management, LLC |
| 0.52% | — | #15 | $486.1万 | 11.0万股 | $0 | 0股 | +11.0万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #76 | $484.6万 | 11.0万股 | $72.4万 | 1.8万股 | +9.2万股+510.05% | 加仓 |
| Ikarian Capital, LLC |
| 0.5% | — | #16 | $472.9万 | 10.8万股 | $0 | 0股 | +10.8万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | — | #69 | $447.1万 | 10.2万股 | $0 | 0股 | +10.2万股 | 新买入 |
