| 木星资产管理Jupiter Topco LLC |
| 0.03% | — | #26 | $7,646.6万 | 574.6万股 | $0 | 0股 | +574.6万股 | 新买入 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.58% | 0.5% | #10 | $6,716.2万 | 505.0万股 | $4,701.3万 | 505.0万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #74 | $6,046.3万 | 454.6万股 | $3,859.3万 | 414.5万股 | +40.1万股+9.67% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #45 | $5,664.0万 | 425.9万股 | $3,915.3万 | 420.5万股 | +5.3万股+1.27% | 加仓 |
| Novo Holdings A/S |
| 2.52% | 2.75% | #3 | $4,321.4万 | 324.9万股 | $3,398.8万 | 365.1万股 | -40.2万股-11.00% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #71 | $3,871.8万 | 291.1万股 | $2,521.0万 | 270.8万股 | +20.3万股+7.51% | 加仓 |
| BVF INC/IL |
| 0.98% | 0.85% | #7 | $3,829.5万 | 287.9万股 | $2,680.6万 | 287.9万股 | 00.00% | 持仓不变 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.02% | — | #31 | $3,340.8万 | 251.2万股 | $0 | 0股 | +251.2万股 | 新买入 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.02% | #25 | $2,991.4万 | 224.9万股 | $1,494.4万 | 160.5万股 | +64.4万股+40.12% | 加仓 |
| Trails Edge Capital Partners, LP |
| 4.7% | 2.78% | #2 | $2,963.1万 | 222.8万股 | $1,213.0万 | 130.3万股 | +92.5万股+70.99% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #89 | $2,791.7万 | 209.9万股 | $0 | 0股 | +209.9万股 | 新买入 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.33% | 0.33% | #12 | $2,660.0万 | 200.0万股 | $1,862.0万 | 200.0万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #79 | $1,501.3万 | 112.8万股 | $992.1万 | 106.5万股 | +6.3万股+5.92% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #72 | $1,490.5万 | 112.1万股 | $907.0万 | 97.4万股 | +14.7万股+15.04% | 加仓 |
| 长青优质基金Evergreen Quality Fund GP, Ltd. |
| 0.2% | 0.2% | #18 | $1,265.5万 | 95.1万股 | $885.8万 | 95.1万股 | 00.00% | 持仓不变 |
| Parkman Healthcare Partners LLC |
| 1.29% | 0.5% | #5 | $1,261.1万 | 94.8万股 | $486.5万 | 52.3万股 | +42.6万股+81.44% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #68 | $1,198.6万 | 90.1万股 | $295.2万 | 31.7万股 | +58.4万股+184.20% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #59 | $971.8万 | 73.1万股 | $486.3万 | 52.3万股 | +20.8万股+39.79% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #53 | $945.6万 | 71.1万股 | $659.2万 | 70.8万股 | +2,898股+0.41% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #38 | $817.4万 | 61.5万股 | $538.4万 | 57.8万股 | +3.6万股+6.28% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #102 | $771.3万 | 58.0万股 | $0 | 0股 | +58.0万股 | 新买入 |
| DIADEMA PARTNERS LP |
| 0.94% | — | #8 | $759.6万 | 57.1万股 | $0 | 0股 | +57.1万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #76 | $748.7万 | 56.3万股 | $318.4万 | 34.2万股 | +22.1万股+64.58% | 加仓 |
| ACUTA CAPITAL PARTNERS, LLC |
| 4.71% | — | #1 | $675.4万 | 50.8万股 | $0 | 0股 | +50.8万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #61 | $669.1万 | 50.3万股 | $523.0万 | 56.2万股 | -5.9万股-10.45% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #101 | $669.0万 | 50.3万股 | $726.4万 | 83.6万股 | -33.3万股-39.82% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.05% | 0.04% | #24 | $632.7万 | 47.6万股 | $442.9万 | 47.6万股 | 00.00% | 持仓不变 |
| Catalio Capital Management, LP |
| 1.18% | — | #6 | $626.8万 | 47.1万股 | $0 | 0股 | +47.1万股 | 新买入 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.02% | 0.01% | #33 | $541.9万 | 40.7万股 | $94.1万 | 10.1万股 | +30.6万股+303.00% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #107 | $518.0万 | 40.2万股 | $356.2万 | 41.6万股 | -1.4万股-3.25% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #86 | $451.2万 | 33.9万股 | $305.7万 | 32.8万股 | +1.1万股+3.32% | 加仓 |
| Opaleye Management Inc. |
| 0.4% | 0.14% | #11 | $444.8万 | 33.4万股 | $104.5万 | 11.2万股 | +22.2万股+197.83% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #78 | $367.4万 | 27.6万股 | $0 | 0股 | +27.6万股 | 新买入 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.13% | 0.13% | #19 | $365.8万 | 27.5万股 | $256.0万 | 27.5万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #95 | $341.4万 | 25.7万股 | $147.2万 | 15.8万股 | +9.9万股+62.33% | 加仓 |
| Propel Bio Management, LLC |
| 1.76% | 2.26% | #4 | $336.0万 | 25.3万股 | $358.1万 | 38.0万股 | -12.8万股-33.59% | 减仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #75 | $322.3万 | 24.2万股 | $247.8万 | 26.6万股 | -2.4万股-8.94% | 减仓 |
| Federated HermesFEDERATED HERMES, INC. |
| <0.01% | 0.02% | #47 | $295.8万 | 22.2万股 | $1,333.4万 | 143.2万股 | -121.0万股-84.47% | 减仓 |
| ArrowMark Colorado Holdings LLC |
| 0.11% | 0.05% | #22 | $269.8万 | 20.3万股 | $188.9万 | 20.3万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #41 | $266.0万 | 20.0万股 | $186.2万 | 20.0万股 | 00.00% | 持仓不变 |
| Brevan Howard资本管理Brevan Howard Capital Management LP |
| 0.01% | — | #34 | $235.2万 | 17.7万股 | $0 | 0股 | +17.7万股 | 新买入 |
| Greenland Capital Management LP |
| 0.28% | — | #15 | $229.1万 | 17.2万股 | $0 | 0股 | +17.2万股 | 新买入 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $217.5万 | 16.4万股 | $18.6万 | 2.0万股 | +14.3万股+713.29% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #104 | $202.6万 | 15.2万股 | $124.4万 | 13.4万股 | +1.9万股+14.02% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #125 | $200.0万 | 15.0万股 | $289.2万 | 31.1万股 | -16.0万股-51.60% | 减仓 |
| Perigon财富管理Perigon Wealth Management, LLC |
| 0.03% | 0.02% | #28 | $194.4万 | 14.6万股 | $136.1万 | 14.6万股 | -12股-0.01% | 减仓 |
| Persistent Asset Partners Ltd |
| 0.59% | — | #9 | $193.6万 | 14.6万股 | $0 | 0股 | +14.6万股 | 新买入 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $186.5万 | 14.0万股 | $42.2万 | 4.5万股 | +9.5万股+209.09% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #126 | $179.0万 | 13.5万股 | $193.7万 | 20.8万股 | -7.3万股-35.32% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #106 | $170.9万 | 12.8万股 | $101.4万 | 10.9万股 | +2.0万股+18.00% | 加仓 |
