| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #56 | $2.14亿 | 886.1万股 | $1.11亿 | 672.0万股 | +214.1万股+31.86% | 加仓 |
| NEA Management Company, LLC |
| 11.72% | 7.19% | #2 | $1.86亿 | 769.2万股 | $1.27亿 | 769.2万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #101 | $1.66亿 | 684.3万股 | $9,274.0万 | 563.8万股 | +120.5万股+21.38% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 2.69% | 2.18% | #7 | $1.12亿 | 462.2万股 | $7,603.4万 | 462.2万股 | 00.00% | 持仓不变 |
| Vestal Point 资本Vestal Point Capital, LP |
| 2.6% | 1.66% | #8 | $1.11亿 | 460.0万股 | $5,927.7万 | 360.3万股 | +99.7万股+27.65% | 加仓 |
| BVF INC/IL |
| 2.76% | 2.34% | #6 | $1.08亿 | 446.1万股 | $7,338.2万 | 446.1万股 | 00.00% | 持仓不变 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.53% | 0.41% | #20 | $1.05亿 | 434.6万股 | $7,148.7万 | 434.6万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #95 | $9,030.0万 | 373.1万股 | $5,517.3万 | 335.4万股 | +37.7万股+11.25% | 加仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 1.57% | 1.78% | #13 | $8,589.9万 | 355.0万股 | $6,953.1万 | 422.7万股 | -67.7万股-16.02% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #113 | $8,259.3万 | 341.3万股 | $5,099.9万 | 310.0万股 | +31.3万股+10.09% | 加仓 |
| Versant Venture Management, LLC |
| 47.34% | 37% | #1 | $7,697.5万 | 318.1万股 | $5,232.4万 | 318.1万股 | 00.00% | 持仓不变 |
| BRAIDWELL LP |
| 2.19% | 1.76% | #9 | $5,932.8万 | 245.2万股 | $5,274.8万 | 320.7万股 | -75.5万股-23.55% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #102 | $4,512.2万 | 186.4万股 | $2,535.3万 | 154.1万股 | +32.3万股+20.98% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #61 | $3,927.3万 | 162.3万股 | $4,621.9万 | 281.0万股 | -118.7万股-42.24% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.03% | 0.02% | #52 | $3,856.5万 | 159.4万股 | $2,357.5万 | 143.3万股 | +16.0万股+11.20% | 加仓 |
| Aisling Capital Management LP |
| 7.98% | 5.37% | #3 | $3,764.7万 | 155.6万股 | $2,559.1万 | 155.6万股 | 00.00% | 持仓不变 |
| Bellevue 集团Bellevue Group AG |
| 0.61% | 0.49% | #17 | $2,879.8万 | 119.0万股 | $2,056.3万 | 125.0万股 | -6.0万股-4.80% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #78 | $2,849.3万 | 117.7万股 | $1,712.5万 | 104.1万股 | +13.6万股+13.07% | 加仓 |
| MPM BioImpact LLC |
| 1.71% | 1.5% | #11 | $2,809.8万 | 116.1万股 | $1,936.0万 | 117.7万股 | -1.6万股-1.35% | 减仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.79% | 3.36% | #5 | $2,682.1万 | 110.8万股 | $3,293.4万 | 200.2万股 | -89.4万股-44.64% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #68 | $2,596.5万 | 107.2万股 | $0 | 0股 | +107.2万股 | 新买入 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.53% | 0.42% | #21 | $2,420.0万 | 100.0万股 | $1,645.0万 | 100.0万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #107 | $2,415.8万 | 99.8万股 | $1,647.5万 | 100.2万股 | -3,274股-0.33% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.07% | <0.01% | #39 | $2,330.2万 | 96.3万股 | $122.5万 | 7.4万股 | +88.8万股+1,192.53% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #129 | $2,261.3万 | 93.4万股 | $1,685.0万 | 102.4万股 | -9.0万股-8.78% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #133 | $1,916.5万 | 79.2万股 | $848.8万 | 51.6万股 | +27.6万股+53.49% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #127 | $1,910.7万 | 79.0万股 | $478.1万 | 64.5万股 | +14.4万股+22.37% | 加仓 |
| Nextech Invest Ltd. |
| 0.88% | 0.35% | #14 | $1,842.0万 | 76.1万股 | $500.5万 | 30.4万股 | +45.7万股+150.18% | 加仓 |
| Opaleye Management Inc. |
| 1.63% | — | #12 | $1,802.9万 | 74.5万股 | $0 | 0股 | +74.5万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #112 | $1,578.1万 | 65.2万股 | $1,359.8万 | 82.7万股 | -17.5万股-21.11% | 减仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.53% | 0.39% | #22 | $1,577.8万 | 65.2万股 | $1,072.5万 | 65.2万股 | 00.00% | 持仓不变 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | — | #71 | $1,567.7万 | 64.8万股 | $0 | 0股 | +64.8万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #108 | $1,491.5万 | 61.6万股 | $899.3万 | 54.7万股 | +7.0万股+12.74% | 加仓 |
| BOONE CAPITAL MANAGEMENT LLC |
| 3.48% | — | #4 | $1,489.0万 | 61.5万股 | $0 | 0股 | +61.5万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.24% | 0.17% | #29 | $1,337.2万 | 55.3万股 | $869.7万 | 52.9万股 | +2.4万股+4.51% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #82 | $1,260.0万 | 52.1万股 | $1,083.2万 | 65.8万股 | -13.8万股-20.93% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #94 | $1,223.3万 | 50.6万股 | $669.6万 | 40.7万股 | +9.8万股+24.18% | 加仓 |
| Parkwood LLC |
| 0.87% | 0.74% | #15 | $1,222.1万 | 50.5万股 | $830.7万 | 50.5万股 | 00.00% | 持仓不变 |
| Alphabet公司Alphabet Inc. |
| 0.26% | 0.28% | #25 | $1,125.6万 | 68.4万股 | $1,125.6万 | 68.4万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.01% | #64 | $1,089.0万 | 45.0万股 | $411.3万 | 25.0万股 | +20.0万股+80.00% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.05% | — | #44 | $997.8万 | 41.2万股 | $0 | 0股 | +41.2万股 | 新买入 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.17% | 0.01% | #32 | $981.4万 | 40.6万股 | $52.6万 | 3.2万股 | +37.4万股+1,168.19% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #111 | $927.7万 | 38.3万股 | $59.2万 | 3.6万股 | +34.7万股+964.91% | 加仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| <0.01% | <0.01% | #97 | $879.7万 | 36.4万股 | $517.9万 | 31.5万股 | +4.9万股+15.45% | 加仓 |
| Allspring环球投资Allspring Global Investments Holdings, LLC |
| 0.01% | 0.01% | #65 | $853.9万 | 35.3万股 | $645.2万 | 39.2万股 | -3.9万股-10.04% | 减仓 |
| Empowered FundsEmpowered Funds, LLC |
| 0.04% | 0.03% | #47 | $796.8万 | 32.9万股 | $502.4万 | 30.5万股 | +2.4万股+7.82% | 加仓 |
| 杜肯家族办公室Duquesne Family Office LLC |
| 0.14% | — | #33 | $720.2万 | 29.8万股 | $0 | 0股 | +29.8万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #77 | $692.0万 | 28.6万股 | $472.1万 | 28.7万股 | -1,042股-0.36% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #153 | $616.0万 | 25.5万股 | $637.5万 | 38.8万股 | -13.3万股-34.31% | 减仓 |
| DIADEMA PARTNERS LP |
| 0.74% | 0.52% | #16 | $601.3万 | 24.8万股 | $308.1万 | 18.7万股 | +6.1万股+32.67% | 加仓 |
