| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 2.02% | 2.08% | #5 | $1.07亿 | 716.5万股 | $1.05亿 | 716.5万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #87 | $1.07亿 | 713.9万股 | $9,012.7万 | 616.0万股 | +97.8万股+15.88% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #80 | $6,684.3万 | 447.4万股 | $5,217.0万 | 356.6万股 | +90.8万股+25.47% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #64 | $5,661.0万 | 378.9万股 | $4,268.1万 | 291.7万股 | +87.2万股+29.88% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #97 | $4,919.3万 | 329.3万股 | $4,732.1万 | 323.5万股 | +5.8万股+1.80% | 加仓 |
| ADAMS STREET PARTNERS LLC |
| 11.06% | 18.41% | #1 | $4,893.8万 | 327.6万股 | $4,792.2万 | 327.6万股 | 00.00% | 持仓不变 |
| Vivo Capital, LLC |
| 3.83% | 3.41% | #3 | $4,191.9万 | 280.6万股 | $4,104.9万 | 280.6万股 | 00.00% | 持仓不变 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #60 | $4,081.1万 | 273.2万股 | $3,392.0万 | 231.9万股 | +41.3万股+17.82% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.6% | 0.66% | #13 | $3,985.2万 | 266.7万股 | $3,353.8万 | 229.2万股 | +37.5万股+16.36% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.54% | 0.6% | #16 | $3,723.0万 | 249.2万股 | $3,645.1万 | 249.2万股 | +400股+0.02% | 加仓 |
| BRAIDWELL LP |
| 1.18% | 0.86% | #9 | $3,176.7万 | 212.6万股 | $2,564.3万 | 175.3万股 | +37.4万股+21.31% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #88 | $2,770.1万 | 185.4万股 | $2,506.4万 | 171.3万股 | +14.1万股+8.23% | 加仓 |
| Foresite Capital Management VI LLC |
| 4.26% | 5.82% | #2 | $2,735.9万 | 183.1万股 | $2,679.1万 | 183.1万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #78 | $2,355.1万 | 157.6万股 | $2,254.2万 | 154.1万股 | +3.6万股+2.31% | 加仓 |
| Hood River资本管理Hood River Capital Management LLC |
| 0.17% | 0.2% | #26 | $2,348.3万 | 157.2万股 | $1,953.3万 | 133.5万股 | +23.7万股+17.73% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #96 | $2,009.0万 | 134.5万股 | $454.9万 | 61.7万股 | +72.8万股+117.87% | 加仓 |
| Boxer Capital Management, LLC |
| 1.24% | 2.11% | #8 | $1,643.4万 | 110.0万股 | $1,609.3万 | 110.0万股 | 00.00% | 持仓不变 |
| Catalio Capital Management, LP |
| 3.03% | 2.73% | #4 | $1,614.8万 | 108.1万股 | $1,304.9万 | 89.2万股 | +18.9万股+21.18% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #91 | $1,568.9万 | 105.0万股 | $1,124.2万 | 76.8万股 | +28.2万股+36.66% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #65 | $1,565.7万 | 104.8万股 | $1,267.5万 | 86.6万股 | +18.2万股+20.96% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #83 | $1,558.0万 | 104.3万股 | $1,335.3万 | 91.3万股 | +13.0万股+14.26% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #122 | $1,217.2万 | 81.5万股 | $980.1万 | 67.0万股 | +14.5万股+21.62% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #57 | $1,173.1万 | 78.5万股 | $789.8万 | 54.0万股 | +24.5万股+45.44% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #114 | $1,132.2万 | 75.8万股 | $346.7万 | 23.7万股 | +52.1万股+219.74% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #52 | $1,120.5万 | 75.0万股 | $1,097.3万 | 75.0万股 | 00.00% | 持仓不变 |
| Eversept Partners, LP |
| 0.58% | — | #14 | $1,117.5万 | 74.8万股 | $0 | 0股 | +74.8万股 | 新买入 |
| EMERALD ADVISERS, LLC |
| 0.24% | 0.32% | #22 | $1,024.4万 | 68.6万股 | $1,003.9万 | 68.6万股 | -533股-0.08% | 减仓 |
| DCF Advisers, LLC |
| 1.68% | 2.49% | #6 | $952.4万 | 63.8万股 | $932.7万 | 63.8万股 | 00.00% | 持仓不变 |
| Blue Owl Capital Holdings LP |
| 1.32% | 2.14% | #7 | $909.2万 | 60.9万股 | $797.3万 | 54.5万股 | +6.4万股+11.67% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #100 | $859.3万 | 57.5万股 | $740.4万 | 50.6万股 | +6.9万股+13.64% | 加仓 |
| EMERALD MUTUAL FUND ADVISERS 信托EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.28% | 0.33% | #20 | $786.4万 | 52.6万股 | $671.9万 | 45.9万股 | +6.7万股+14.62% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #85 | $777.7万 | 52.1万股 | $738.3万 | 50.5万股 | +1.6万股+3.15% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.06% | 0.07% | #36 | $672.3万 | 45.0万股 | $658.4万 | 45.0万股 | 00.00% | 持仓不变 |
| Nextech Invest Ltd. |
| 0.32% | 0.46% | #19 | $672.3万 | 45.0万股 | $658.4万 | 45.0万股 | 00.00% | 持仓不变 |
| DIADEMA PARTNERS LP |
| 0.79% | 0.87% | #10 | $639.7万 | 42.8万股 | $513.7万 | 35.1万股 | +7.7万股+21.96% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #111 | $591.8万 | 39.6万股 | $423.0万 | 28.9万股 | +10.7万股+37.01% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.03% | 0.01% | #44 | $546.0万 | 36.5万股 | $234.1万 | 16.0万股 | +20.5万股+128.40% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #107 | $471.7万 | 31.6万股 | $356.6万 | 24.4万股 | +7.2万股+29.52% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| 0.04% | 0.03% | #39 | $468.2万 | 31.3万股 | $216.3万 | 14.8万股 | +16.6万股+111.97% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.03% | — | #43 | $442.7万 | 29.6万股 | $0 | 0股 | +29.6万股 | 新买入 |
| Polymer Capital Management (HK) LTD |
| 0.2% | 0.23% | #24 | $393.9万 | 26.4万股 | $268.0万 | 18.3万股 | +8.0万股+43.93% | 加仓 |
| Brevan Howard资本管理Brevan Howard Capital Management LP |
| 0.02% | 0.02% | #46 | $373.9万 | 25.0万股 | $245.7万 | 16.8万股 | +8.2万股+49.01% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.48% | 0.58% | #17 | $366.0万 | 24.5万股 | $362.8万 | 24.8万股 | -3,000股-1.21% | 减仓 |
| Spruce Street Capital LP |
| 0.68% | 0.81% | #11 | $346.0万 | 23.2万股 | $338.8万 | 23.2万股 | 00.00% | 持仓不变 |
| SEB资产管理SEB Asset Management AB |
| 0.01% | 0.01% | #55 | $338.9万 | 22.7万股 | $331.9万 | 22.7万股 | 00.00% | 持仓不变 |
| 胜利资本管理VICTORY CAPITAL MANAGEMENT INC |
| <0.01% | <0.01% | #82 | $329.8万 | 22.1万股 | $187.8万 | 12.8万股 | +9.2万股+72.00% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | <0.01% | #62 | $325.3万 | 21.8万股 | $122.8万 | 8.4万股 | +13.4万股+159.51% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #128 | $310.9万 | 20.8万股 | $275.2万 | 18.8万股 | +2.0万股+10.63% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #123 | $302.7万 | 20.3万股 | $271.2万 | 18.5万股 | +1.7万股+9.31% | 加仓 |
| F/m Investments LLC |
| 0.13% | 0.1% | #29 | $249.7万 | 16.7万股 | $146.3万 | 10.0万股 | +6.7万股+67.12% | 加仓 |
