| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #56 | $1.24亿 | 130.8万股 | $1,491.5万 | 44.3万股 | +86.5万股+195.37% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 1.85% | 1.9% | #5 | $1.23亿 | 129.8万股 | $9,699.3万 | 144.3万股 | -14.5万股-10.05% | 减仓 |
| Sanofi |
| 20.54% | 23.17% | #1 | $1.10亿 | 115.8万股 | $7,784.7万 | 115.8万股 | 00.00% | 持仓不变 |
| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 0.3% | 0.27% | #12 | $1.06亿 | 112.4万股 | $9,665.7万 | 143.8万股 | -31.4万股-21.82% | 减仓 |
| HighTower顾问HighTower Advisors, LLC |
| 0.08% | 0.06% | #28 | $8,248.5万 | 87.1万股 | $5,850.4万 | 87.0万股 | +351股+0.04% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #58 | $7,969.8万 | 84.1万股 | $219.7万 | 3.3万股 | +80.8万股+2,473.63% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #88 | $7,826.1万 | 82.6万股 | $5,371.0万 | 79.9万股 | +2.7万股+3.39% | 加仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.23% | 0.12% | #15 | $6,609.6万 | 69.8万股 | $1,713.2万 | 25.5万股 | +44.3万股+173.75% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #80 | $6,068.3万 | 64.0万股 | $3,703.3万 | 55.1万股 | +9.0万股+16.27% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $4,666.2万 | 49.2万股 | $3,270.2万 | 48.6万股 | +6,055股+1.24% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #63 | $3,834.3万 | 40.5万股 | $1,086.3万 | 16.2万股 | +24.3万股+150.46% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.12% | 0.1% | #21 | $3,798.5万 | 40.1万股 | $2,584.5万 | 38.4万股 | +1.6万股+4.28% | 加仓 |
| 资本研究全球投资者Capital Research Global Investors |
| <0.01% | <0.01% | #59 | $3,439.9万 | 36.3万股 | $2,641.1万 | 39.3万股 | -3.0万股-7.58% | 减仓 |
| PFM Health Sciences, LP |
| 2.51% | 1.87% | #3 | $2,921.9万 | 30.8万股 | $2,053.4万 | 30.5万股 | +2,954股+0.97% | 加仓 |
| Sofinnova Investments, Inc. |
| 1.48% | 1.04% | #9 | $2,871.9万 | 30.3万股 | $2,729.7万 | 40.6万股 | -10.3万股-25.35% | 减仓 |
| 安大略医疗养老基金(HOOPP)HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.04% | 0.02% | #35 | $2,574.4万 | 27.2万股 | $1,147.6万 | 17.1万股 | +10.1万股+59.17% | 加仓 |
| Parkman Healthcare Partners LLC |
| 2.49% | — | #4 | $2,434.6万 | 25.7万股 | $0 | 0股 | +25.7万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #86 | $2,427.8万 | 25.6万股 | $1,556.8万 | 23.2万股 | +2.5万股+10.65% | 加仓 |
| CDC Financial, Inc. |
| 6.75% | 7.97% | #2 | $1,612.0万 | 17.0万股 | $1,254.0万 | 18.7万股 | -1.6万股-8.79% | 减仓 |
| First Turn Management, LLC |
| 1.67% | — | #6 | $1,561.3万 | 16.5万股 | $0 | 0股 | +16.5万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #60 | $1,394.7万 | 14.7万股 | $2,204.2万 | 32.8万股 | -18.1万股-55.10% | 减仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | — | #54 | $1,216.8万 | 12.8万股 | $0 | 0股 | +12.8万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #108 | $1,161.2万 | 12.3万股 | $487.1万 | 7.2万股 | +5.0万股+69.14% | 加仓 |
| Capitolis全球市场CAPITOLIS LIQUID GLOBAL MARKETS LLC |
| 0.05% | 0.05% | #31 | $1,129.4万 | 11.9万股 | $840.4万 | 12.5万股 | -5,800股-4.64% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #96 | $970.0万 | 10.2万股 | $1,058.0万 | 15.7万股 | -5.5万股-34.95% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #89 | $956.6万 | 10.1万股 | $629.9万 | 9.4万股 | +7,261股+7.75% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | — | #93 | $855.6万 | 9.0万股 | $0 | 0股 | +9.0万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #70 | $717.5万 | 7.6万股 | $420.3万 | 6.3万股 | +1.3万股+21.12% | 加仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.05% | 0.02% | #32 | $695.6万 | 7.3万股 | $262.0万 | 3.9万股 | +3.4万股+88.38% | 加仓 |
| 野村控股NOMURA HOLDINGS INC |
| 0.01% | <0.01% | #50 | $695.5万 | 7.3万股 | $104.2万 | 1.6万股 | +5.8万股+373.55% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #84 | $662.5万 | 7.0万股 | $432.4万 | 6.4万股 | +5,598股+8.70% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #52 | $589.4万 | 6.2万股 | $337.4万 | 5.0万股 | +1.2万股+23.95% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.08% | — | #30 | $583.1万 | 6.2万股 | $0 | 0股 | +6.2万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #66 | $567.0万 | 6.0万股 | $218.8万 | 3.3万股 | +2.7万股+83.91% | 加仓 |
| 沃利昂资本管理Voleon Capital Management LP |
| 0.1% | 0.06% | #23 | $552.9万 | 5.8万股 | $264.2万 | 3.9万股 | +1.9万股+48.47% | 加仓 |
| Voloridge投资管理VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.02% | <0.01% | #42 | $462.0万 | 4.9万股 | $90.8万 | 1.4万股 | +3.5万股+261.20% | 加仓 |
| Western Standard LLC |
| 1.51% | — | #8 | $445.3万 | 4.7万股 | $0 | 0股 | +4.7万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #74 | $426.6万 | 4.5万股 | $673.2万 | 10.0万股 | -5.5万股-55.04% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #112 | $404.6万 | 4.3万股 | $478.4万 | 7.1万股 | -2.8万股-39.99% | 减仓 |
| Caption管理Caption Management, LLC |
| 0.02% | 0.01% | #43 | $382.8万 | 4.0万股 | $118.3万 | 1.8万股 | +2.3万股+129.55% | 加仓 |
| 胜利资本管理VICTORY CAPITAL MANAGEMENT INC |
| <0.01% | <0.01% | #76 | $345.3万 | 3.6万股 | $73.4万 | 1.1万股 | +2.6万股+233.60% | 加仓 |
| ArrowMark Colorado Holdings LLC |
| 0.14% | 0.06% | #20 | $333.3万 | 3.5万股 | $236.5万 | 3.5万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #114 | $331.8万 | 3.5万股 | $323.6万 | 4.8万股 | -1.3万股-27.25% | 减仓 |
| HUSSMAN STRATEGIC ADVISORS, INC. |
| 0.69% | — | #10 | $298.5万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| Empyrean 资本合伙人Empyrean Capital Partners, LP |
| 0.09% | — | #25 | $284.3万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| Atom Investors LP |
| 0.25% | 0.13% | #14 | $280.4万 | 3.0万股 | $178.2万 | 2.7万股 | +3,089股+11.65% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #119 | $271.7万 | 2.9万股 | $172.6万 | 2.6万股 | +3,007股+11.71% | 加仓 |
| Corient私人财富Corient Private Wealth LLC |
| <0.01% | <0.01% | #73 | $271.5万 | 2.9万股 | $193.7万 | 2.9万股 | -161股-0.56% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #116 | $248.2万 | 2.6万股 | $174.0万 | 2.6万股 | +326股+1.26% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | — | #65 | $246.5万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
