| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #97 | $2.13亿 | 877.0万股 | $1.38亿 | 892.6万股 | -15.5万股-1.74% | 减仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 4.56% | 2.82% | #3 | $1.95亿 | 805.0万股 | $1.01亿 | 650.0万股 | +155.0万股+23.85% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 2.73% | 1.61% | #5 | $1.88亿 | 773.6万股 | $9,835.1万 | 634.5万股 | +139.1万股+21.93% | 加仓 |
| Rubric资本管理Rubric Capital Management LP |
| 1.61% | 0.41% | #8 | $1.75亿 | 722.8万股 | $3,834.5万 | 247.4万股 | +475.4万股+192.16% | 加仓 |
| 富达投资FMR LLC |
| 0.01% | <0.01% | #74 | $1.33亿 | 548.5万股 | $8,589.0万 | 554.1万股 | -5.6万股-1.01% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #62 | $1.32亿 | 543.7万股 | $5,099.9万 | 329.0万股 | +214.6万股+65.23% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #73 | $1.16亿 | 476.2万股 | $2,088.9万 | 226.1万股 | +250.2万股+110.66% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #93 | $1.13亿 | 467.7万股 | $7,968.9万 | 514.1万股 | -46.4万股-9.02% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.57% | 0.41% | #21 | $1.13亿 | 465.9万股 | $7,220.8万 | 465.9万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #106 | $1.09亿 | 449.6万股 | $6,862.0万 | 442.7万股 | +6.8万股+1.55% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 1.57% | 1.12% | #10 | $1.05亿 | 432.0万股 | $5,751.9万 | 371.1万股 | +61.0万股+16.43% | 加仓 |
| Redmile Group, LLC |
| 6.64% | 7.94% | #1 | $9,883.0万 | 407.4万股 | $1.20亿 | 773.3万股 | -365.9万股-47.32% | 减仓 |
| GENERAL ATLANTIC, L.P. |
| 2.53% | 2.96% | #6 | $7,356.1万 | 303.2万股 | $6,357.9万 | 410.2万股 | -107.0万股-26.08% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #95 | $6,156.7万 | 253.7万股 | $3,907.0万 | 252.0万股 | +1.7万股+0.68% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.05% | 0.04% | #46 | $5,704.1万 | 235.1万股 | $4,225.5万 | 272.6万股 | -37.5万股-13.75% | 减仓 |
| ARK投资管理ARK Investment Management LLC |
| 0.28% | 0.21% | #33 | $4,350.3万 | 179.3万股 | $2,667.8万 | 172.1万股 | +7.2万股+4.19% | 加仓 |
| 资本世界投资者Capital World Investors |
| 0.01% | <0.01% | #79 | $4,337.5万 | 178.8万股 | $1,384.7万 | 89.3万股 | +89.5万股+100.14% | 加仓 |
| Trails Edge Capital Partners, LP |
| 6.06% | 6.19% | #2 | $3,816.6万 | 157.3万股 | $2,702.0万 | 174.3万股 | -17.0万股-9.75% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #83 | $3,710.4万 | 152.9万股 | $2,139.5万 | 138.0万股 | +14.9万股+10.80% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #116 | $3,597.4万 | 148.3万股 | $1,708.5万 | 110.2万股 | +38.1万股+34.53% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 1.22% | 0.59% | #12 | $3,554.5万 | 146.5万股 | $1,454.2万 | 93.8万股 | +52.7万股+56.17% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #70 | $3,472.0万 | 143.1万股 | $1,209.4万 | 78.1万股 | +65.1万股+83.34% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.42% | 0.33% | #24 | $3,148.7万 | 129.8万股 | $2,011.7万 | 129.8万股 | 00.00% | 持仓不变 |
| BRAIDWELL LP |
| 1.15% | 0.91% | #13 | $3,121.7万 | 128.7万股 | $2,713.7万 | 175.1万股 | -46.4万股-26.50% | 减仓 |
| Kynam Capital Management, LP |
| 1.6% | 1.14% | #9 | $2,898.5万 | 119.5万股 | $1,851.9万 | 119.5万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.08% | 0.05% | #42 | $2,581.3万 | 106.4万股 | $1,434.4万 | 92.5万股 | +13.9万股+14.97% | 加仓 |
| 三井住友信托集团Sumitomo Mitsui Trust Group, Inc. |
| 0.01% | 0.01% | #61 | $2,385.9万 | 98.3万股 | $1,830.8万 | 118.1万股 | -19.8万股-16.74% | 减仓 |
| Amova资产管理Amova Asset Management Americas, Inc. |
| 0.31% | 0.26% | #32 | $2,384.9万 | 98.3万股 | $1,828.4万 | 118.1万股 | -19.8万股-16.74% | 减仓 |
| Affinity Asset Advisors, LLC |
| 1.06% | 0.77% | #16 | $2,347.4万 | 96.8万股 | $1,499.8万 | 96.8万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #100 | $2,224.9万 | 91.7万股 | $1,513.4万 | 97.6万股 | -5.9万股-6.07% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #104 | $2,125.3万 | 87.6万股 | $1,324.4万 | 85.4万股 | +2.2万股+2.53% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #127 | $2,042.9万 | 84.2万股 | $1,243.3万 | 80.2万股 | +4.0万股+4.98% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #101 | $2,021.6万 | 83.3万股 | $1,432.3万 | 92.4万股 | -9.1万股-9.82% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #81 | $2,003.5万 | 82.6万股 | $1,259.5万 | 81.3万股 | +1.3万股+1.63% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #114 | $1,973.8万 | 81.4万股 | $2,043.9万 | 131.9万股 | -50.5万股-38.30% | 减仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.31% | 0.18% | #31 | $1,757.7万 | 72.5万股 | $869.9万 | 56.1万股 | +16.3万股+29.09% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #91 | $1,665.1万 | 68.6万股 | $980.0万 | 63.2万股 | +5.4万股+8.56% | 加仓 |
| Rhenman & Partners Asset Management AB |
| 1.57% | 0.6% | #11 | $1,660.0万 | 68.4万股 | $485.9万 | 31.4万股 | +37.1万股+118.26% | 加仓 |
| Handelsbanken Fonder AB |
| 0.04% | 0.03% | #50 | $1,535.7万 | 63.3万股 | $847.8万 | 54.7万股 | +8.6万股+15.72% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #88 | $1,439.3万 | 59.3万股 | $520.0万 | 35.4万股 | +24.0万股+67.71% | 加仓 |
| Sofinnova Investments, Inc. |
| 0.66% | — | #19 | $1,271.5万 | 52.4万股 | $0 | 0股 | +52.4万股 | 新买入 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | — | #78 | $1,157.5万 | 47.7万股 | $0 | 0股 | +47.7万股 | 新买入 |
| Elmind Capital, LP |
| 2.8% | 2.02% | #4 | $1,116.0万 | 46.0万股 | $713.0万 | 46.0万股 | 00.00% | 持仓不变 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #98 | $944.6万 | 38.9万股 | $740.0万 | 47.7万股 | -8.8万股-18.44% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.04% | 0.05% | #51 | $915.9万 | 37.8万股 | $1,013.5万 | 53.4万股 | -15.6万股-29.27% | 减仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| <0.01% | <0.01% | #102 | $896.3万 | 36.9万股 | $596.5万 | 38.5万股 | -1.5万股-3.99% | 减仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.03% | 0.04% | #54 | $882.1万 | 36.4万股 | $962.3万 | 62.1万股 | -25.7万股-41.43% | 减仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | — | #77 | $875.4万 | 36.1万股 | $0 | 0股 | +36.1万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #86 | $826.2万 | 34.1万股 | $346.2万 | 22.3万股 | +11.7万股+52.48% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #124 | $810.6万 | 33.4万股 | $498.1万 | 32.1万股 | +1.3万股+3.98% | 加仓 |
