| 富达投资FMR LLC |
| 0.01% | 0.01% | #40 | $2.41亿 | 950.7万股 | $1.78亿 | 908.2万股 | +42.5万股+4.68% | 加仓 |
| SR ONE CAPITAL MANAGEMENT, LP |
| 12.31% | 10.76% | #3 | $1.28亿 | 503.8万股 | $9,849.0万 | 503.8万股 | 00.00% | 持仓不变 |
| NEA Management Company, LLC |
| 6.43% | 4.47% | #4 | $1.02亿 | 402.3万股 | $7,865.4万 | 402.3万股 | 00.00% | 持仓不变 |
| Enavate Sciences GP, LLC |
| 28.8% | 21.8% | #1 | $9,946.8万 | 391.9万股 | $7,662.0万 | 391.9万股 | 00.00% | 持仓不变 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.11% | 0.1% | #20 | $7,910.5万 | 311.7万股 | $6,113.3万 | 312.7万股 | -1.0万股-0.33% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #70 | $6,817.6万 | 268.6万股 | $3,983.4万 | 203.8万股 | +64.9万股+31.84% | 加仓 |
| 资本国际投资者Capital International Investors |
| 0.01% | 0.01% | #38 | $6,352.4万 | 250.3万股 | $4,758.5万 | 243.4万股 | +6.9万股+2.83% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.14% | 0.18% | #18 | $6,123.6万 | 241.3万股 | $4,982.2万 | 254.8万股 | -13.6万股-5.32% | 减仓 |
| Fairmount Funds Management LLC |
| 3.96% | 3.33% | #7 | $5,987.2万 | 235.9万股 | $4,611.9万 | 235.9万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #64 | $5,215.8万 | 205.5万股 | $2,875.7万 | 147.1万股 | +58.4万股+39.71% | 加仓 |
| NVP Associates, LLC |
| 14.22% | 20.4% | #2 | $4,666.1万 | 183.8万股 | $3,594.2万 | 183.8万股 | 00.00% | 持仓不变 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | <0.01% | #46 | $4,045.1万 | 159.4万股 | $2,436.0万 | 124.6万股 | +34.8万股+27.91% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #74 | $3,438.6万 | 135.5万股 | $2,434.7万 | 124.5万股 | +10.9万股+8.79% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #58 | $3,124.7万 | 123.1万股 | $759.2万 | 38.8万股 | +84.3万股+217.03% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #54 | $3,113.9万 | 122.7万股 | $698.6万 | 35.7万股 | +87.0万股+243.42% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #68 | $2,240.6万 | 88.3万股 | $1,282.4万 | 65.6万股 | +22.7万股+34.60% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #45 | $2,157.1万 | 110.3万股 | $3,258.2万 | 89.7万股 | +20.6万股+22.96% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #35 | $2,068.9万 | 81.5万股 | $537.7万 | 27.5万股 | +54.0万股+196.36% | 加仓 |
| EcoR1 Capital, LLC |
| 0.97% | 0.66% | #10 | $2,003.8万 | 79.0万股 | $1,543.5万 | 79.0万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #48 | $1,676.3万 | 66.0万股 | $932.2万 | 47.7万股 | +18.4万股+38.52% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.05% | 0.04% | #27 | $1,498.8万 | 59.1万股 | $1,154.5万 | 59.1万股 | +14股+0.00% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #34 | $1,463.7万 | 57.7万股 | $1,304.1万 | 66.7万股 | -9.0万股-13.54% | 减仓 |
| ArrowMark Colorado Holdings LLC |
| 0.61% | 0.34% | #15 | $1,455.1万 | 57.3万股 | $1,288.2万 | 65.9万股 | -8.6万股-12.99% | 减仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 1.34% | 2.27% | #8 | $1,293.8万 | 51.0万股 | $2,220.8万 | 113.6万股 | -62.6万股-55.12% | 减仓 |
| Rock Springs Capital Management LP |
| 0.62% | 0.58% | #14 | $1,274.3万 | 50.2万股 | $981.6万 | 50.2万股 | 00.00% | 持仓不变 |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 4.05% | 4.14% | #6 | $1,245.6万 | 49.1万股 | $1,157.3万 | 59.2万股 | -10.1万股-17.10% | 减仓 |
| NEXTBio Capital Management LP |
| 4.98% | 3.87% | #5 | $1,083.1万 | 42.7万股 | $834.3万 | 42.7万股 | 00.00% | 持仓不变 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.22% | 0.11% | #16 | $926.4万 | 36.5万股 | $391.0万 | 20.0万股 | +16.5万股+82.50% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.01% | #47 | $820.9万 | 32.3万股 | $981.3万 | 50.2万股 | -17.8万股-35.56% | 减仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| <0.01% | <0.01% | #49 | $797.1万 | 31.4万股 | $488.8万 | 25.0万股 | +6.4万股+25.62% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #94 | $773.8万 | 30.5万股 | $491.5万 | 25.1万股 | +5.3万股+21.26% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #69 | $766.7万 | 30.2万股 | $438.7万 | 22.4万股 | +7.8万股+34.62% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #71 | $713.5万 | 28.1万股 | $380.5万 | 19.5万股 | +8.7万股+44.44% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #79 | $688.2万 | 27.1万股 | $745.8万 | 38.1万股 | -11.0万股-28.91% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #65 | $646.2万 | 25.5万股 | $350.7万 | 17.9万股 | +7.5万股+41.94% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #86 | $622.1万 | 24.5万股 | $520.0万 | 26.6万股 | -2.1万股-7.86% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.77% | 0.67% | #13 | $585.9万 | 23.1万股 | $419.0万 | 21.4万股 | +1.7万股+7.70% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #77 | $575.3万 | 22.7万股 | $249.6万 | 12.8万股 | +9.9万股+77.55% | 加仓 |
| iA Global Asset Management Inc. |
| 0.06% | 0.06% | #26 | $546.0万 | 21.5万股 | $421.9万 | 21.6万股 | -700股-0.32% | 减仓 |
| Walleye资本Walleye Capital LLC |
| 0.02% | 0.01% | #33 | $530.6万 | 20.9万股 | $244.8万 | 12.5万股 | +8.4万股+66.93% | 加仓 |
| Sio Capital Management, LLC |
| 0.88% | 0.93% | #11 | $529.3万 | 20.9万股 | $648.5万 | 33.2万股 | -12.3万股-37.13% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #80 | $452.0万 | 17.8万股 | $718.3万 | 36.7万股 | -18.9万股-51.53% | 减仓 |
| 沃利昂资本管理Voleon Capital Management LP |
| 0.08% | 0.01% | #25 | $424.2万 | 16.7万股 | $57.9万 | 3.0万股 | +13.8万股+464.45% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #61 | $383.5万 | 15.1万股 | $19.5万 | 9,999股 | +14.1万股+1,411.01% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #110 | $342.6万 | 13.5万股 | $197.0万 | 8.9万股 | +4.6万股+52.12% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #53 | $317.7万 | 12.5万股 | $83.8万 | 4.3万股 | +8.2万股+191.98% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #81 | $294.3万 | 11.6万股 | $57.9万 | 3.0万股 | +8.6万股+291.64% | 加仓 |
| SEVEN GRAND MANAGERS, LLC |
| 0.1% | 0.13% | #21 | $253.8万 | 10.0万股 | $195.5万 | 10.0万股 | 00.00% | 持仓不变 |
| Birchview Capital, LP |
| 1.07% | 0.78% | #9 | $237.6万 | 9.4万股 | $136.9万 | 7.0万股 | +2.4万股+33.72% | 加仓 |
| Verition基金管理Verition Fund Management LLC |
| <0.01% | — | #55 | $185.2万 | 7.3万股 | $0 | 0股 | +7.3万股 | 新买入 |
