| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.49% | 1.65% | #2 | $1.72亿 | 1,119.0万股 | $1.56亿 | 1,119.0万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #85 | $9,422.8万 | 613.5万股 | $7,552.2万 | 543.3万股 | +70.1万股+12.91% | 加仓 |
| Prosight Management, LP |
| 10.07% | 8.09% | #1 | $5,843.7万 | 380.4万股 | $4,934.5万 | 355.0万股 | +25.4万股+7.17% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #87 | $4,615.5万 | 300.5万股 | $3,425.0万 | 246.4万股 | +54.1万股+21.95% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #81 | $3,706.1万 | 241.3万股 | $3,524.7万 | 253.6万股 | -12.3万股-4.85% | 减仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.05% | <0.01% | #27 | $3,614.1万 | 235.3万股 | $75.3万 | 5.4万股 | +229.9万股+4,241.19% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.03% | 0.02% | #32 | $3,062.5万 | 199.4万股 | $1,607.0万 | 115.6万股 | +83.8万股+72.46% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #113 | $2,852.9万 | 185.7万股 | $2,517.8万 | 181.1万股 | +4.6万股+2.54% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.66% | 0.71% | #7 | $2,748.9万 | 179.0万股 | $2,487.6万 | 179.0万股 | 00.00% | 持仓不变 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.07% | 0.06% | #25 | $2,530.0万 | 164.7万股 | $2,225.5万 | 160.1万股 | +4.6万股+2.88% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #60 | $2,315.3万 | 150.7万股 | $2,220.7万 | 159.8万股 | -9.0万股-5.65% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #99 | $2,044.0万 | 133.1万股 | $1,793.5万 | 129.0万股 | +4.0万股+3.14% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #72 | $1,942.8万 | 126.5万股 | $618.0万 | 44.5万股 | +82.0万股+184.50% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #41 | $1,854.3万 | 120.7万股 | $161.4万 | 11.6万股 | +109.1万股+939.85% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #97 | $1,850.0万 | 120.4万股 | $1,594.3万 | 114.7万股 | +5.7万股+5.01% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.2% | 0.09% | #13 | $1,706.3万 | 111.1万股 | $616.3万 | 44.3万股 | +66.7万股+150.54% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | <0.01% | #50 | $1,684.2万 | 109.7万股 | $136.8万 | 9.8万股 | +99.8万股+1,014.40% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #89 | $1,463.3万 | 95.3万股 | $836.8万 | 60.2万股 | +35.1万股+58.25% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #100 | $1,398.5万 | 91.0万股 | $1,114.3万 | 80.2万股 | +10.9万股+13.57% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #109 | $1,285.6万 | 83.7万股 | $1,211.3万 | 49.6万股 | +34.1万股+68.87% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.41% | 0.41% | #9 | $1,244.0万 | 81.0万股 | $1,125.8万 | 81.0万股 | 00.00% | 持仓不变 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #46 | $1,078.4万 | 70.2万股 | $274.0万 | 19.7万股 | +50.5万股+256.11% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.01% | 0.01% | #47 | $817.6万 | 53.2万股 | $839.6万 | 60.4万股 | -7.2万股-11.87% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.15% | 0.27% | #17 | $805.9万 | 52.5万股 | $1,367.2万 | 98.4万股 | -45.9万股-46.66% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #70 | $775.0万 | 50.5万股 | $537.7万 | 38.7万股 | +11.8万股+30.44% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| 0.01% | 0.01% | #40 | $754.2万 | 49.1万股 | $509.7万 | 36.7万股 | +12.4万股+33.90% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #115 | $718.7万 | 46.8万股 | $430.3万 | 31.0万股 | +15.8万股+51.16% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.3% | 0.24% | #11 | $646.5万 | 42.1万股 | $415.0万 | 29.9万股 | +12.2万股+40.98% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #107 | $611.9万 | 39.8万股 | $503.4万 | 36.2万股 | +3.6万股+9.99% | 加仓 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. |
| 0.32% | 0.44% | #10 | $578.3万 | 37.6万股 | $523.3万 | 37.6万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | 0.04% | #35 | $568.4万 | 37.0万股 | $1,025.9万 | 73.8万股 | -36.8万股-49.86% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #104 | $567.1万 | 36.9万股 | $492.5万 | 35.4万股 | +1.5万股+4.19% | 加仓 |
| Rock Springs Capital Management LP |
| 0.28% | 0.3% | #12 | $563.7万 | 36.7万股 | $510.1万 | 36.7万股 | 00.00% | 持仓不变 |
| 跳跃金融Jump Financial, LLC |
| 0.04% | 0.04% | #30 | $555.5万 | 36.2万股 | $308.3万 | 22.2万股 | +14.0万股+63.06% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #95 | $552.5万 | 36.0万股 | $134.3万 | 9.7万股 | +26.3万股+272.27% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #93 | $484.3万 | 31.5万股 | $436.0万 | 31.4万股 | +1,623股+0.52% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #134 | $414.9万 | 27.0万股 | $1,011.0万 | 72.7万股 | -45.7万股-62.87% | 减仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.01% | — | #42 | $413.4万 | 26.9万股 | $0 | 0股 | +26.9万股 | 新买入 |
| 英仕曼集团Man Group plc |
| 0.01% | 0.01% | #54 | $382.2万 | 24.9万股 | $476.8万 | 34.3万股 | -9.4万股-27.46% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | 0.02% | #59 | $325.1万 | 21.2万股 | $1,515.3万 | 109.0万股 | -87.9万股-80.59% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #83 | $321.9万 | 21.0万股 | $146.4万 | 10.5万股 | +10.4万股+99.04% | 加仓 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.06% | 0.04% | #26 | $301.8万 | 19.6万股 | $194.6万 | 14.0万股 | +5.7万股+40.38% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #158 | $273.6万 | 17.9万股 | $298.7万 | 22.9万股 | -5.1万股-22.13% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| <0.01% | — | #92 | $264.6万 | 17.2万股 | $0 | 0股 | +17.2万股 | 新买入 |
| Allspring环球投资Allspring Global Investments Holdings, LLC |
| <0.01% | <0.01% | #63 | $243.5万 | 16.6万股 | $245.2万 | 16.9万股 | -2,884股-1.71% | 减仓 |
| BML Capital Management, LLC |
| 1.36% | 1.38% | #5 | $238.0万 | 15.5万股 | $215.4万 | 15.5万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #138 | $231.5万 | 15.1万股 | $305.5万 | 22.0万股 | -6.9万股-31.44% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #131 | $207.5万 | 13.5万股 | $166.6万 | 12.0万股 | +1.5万股+12.72% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #61 | $205.6万 | 13.4万股 | $165.9万 | 11.9万股 | +1.4万股+12.14% | 加仓 |
| THRIVENT FINANCIAL FOR LUTHERANS |
| <0.01% | — | #68 | $176.7万 | 11.5万股 | $0 | 0股 | +11.5万股 | 新买入 |
