| 富达投资FMR LLC |
| <0.01% | <0.01% | #73 | $1.11亿 | 1,951.8万股 | $5,892.1万 | 1,063.6万股 | +888.3万股+83.52% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #110 | $7,731.2万 | 1,354.0万股 | $6,059.9万 | 1,093.9万股 | +260.1万股+23.78% | 加仓 |
| Redmile Group, LLC |
| 4.55% | 5.34% | #2 | $6,777.7万 | 1,187.0万股 | $8,060.6万 | 1,455.0万股 | -268.0万股-18.42% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #98 | $5,609.7万 | 982.4万股 | $3,833.3万 | 691.9万股 | +290.5万股+41.99% | 加仓 |
| BVF INC/IL |
| 1.27% | 1.54% | #7 | $4,966.7万 | 869.8万股 | $4,818.8万 | 869.8万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.12% | 0.05% | #21 | $3,954.2万 | 692.5万股 | $1,294.8万 | 233.7万股 | +458.8万股+196.31% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #124 | $3,923.3万 | 687.1万股 | $3,300.0万 | 595.7万股 | +91.4万股+15.35% | 加仓 |
| MAK CAPITAL ONE LLC |
| 4.69% | 3.86% | #1 | $3,347.3万 | 586.2万股 | $2,617.1万 | 472.4万股 | +113.8万股+24.09% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #85 | $3,326.4万 | 582.6万股 | $1,192.7万 | 215.3万股 | +367.3万股+170.59% | 加仓 |
| Siren, L.L.C. |
| 0.52% | 0.61% | #12 | $2,545.9万 | 445.9万股 | $2,193.1万 | 395.9万股 | +50.0万股+12.63% | 加仓 |
| Bain Capital Life Sciences Investors, LLC |
| 1.51% | 2.6% | #6 | $2,533.9万 | 443.8万股 | $2,887.8万 | 521.3万股 | -77.5万股-14.87% | 减仓 |
| Bellevue 集团Bellevue Group AG |
| 0.49% | 0.68% | #13 | $2,341.1万 | 410.0万股 | $2,857.1万 | 515.7万股 | -105.7万股-20.50% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $2,305.6万 | 403.7万股 | $1,871.8万 | 337.8万股 | +65.9万股+19.52% | 加仓 |
| MPM BioImpact LLC |
| 1.23% | — | #8 | $2,023.8万 | 354.4万股 | $0 | 0股 | +354.4万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #76 | $2,004.0万 | 351.0万股 | $1,910.8万 | 344.9万股 | +6.1万股+1.75% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.04% | #41 | $1,998.5万 | 350.0万股 | $2,382.2万 | 430.0万股 | -80.0万股-18.60% | 减仓 |
| GREAT POINT PARTNERS LLC |
| 3.78% | 3.18% | #3 | $1,998.5万 | 350.0万股 | $1,385.0万 | 250.0万股 | +100.0万股+40.00% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #117 | $1,795.5万 | 314.4万股 | $924.1万 | 303.0万股 | +11.5万股+3.78% | 加仓 |
| Palo Alto Investors LP |
| 2.46% | 2.5% | #5 | $1,683.4万 | 294.8万股 | $1,633.2万 | 294.8万股 | 00.00% | 持仓不变 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.03% | #46 | $1,616.5万 | 283.1万股 | $2,153.3万 | 388.7万股 | -105.6万股-27.17% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | 0.01% | #77 | $1,578.9万 | 276.5万股 | $2,352.5万 | 424.6万股 | -148.1万股-34.88% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.02% | #49 | $1,570.2万 | 275.0万股 | $1,725.3万 | 311.4万股 | -36.4万股-11.70% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #135 | $1,282.9万 | 224.7万股 | $821.6万 | 148.3万股 | +76.4万股+51.49% | 加仓 |
| Opaleye Management Inc. |
| 0.89% | 1.7% | #10 | $979.0万 | 171.4万股 | $1,291.8万 | 233.2万股 | -61.7万股-26.47% | 减仓 |
| Logos Global Management LP |
| 0.37% | — | #16 | $856.5万 | 150.0万股 | $0 | 0股 | +150.0万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #100 | $855.1万 | 149.8万股 | $511.5万 | 92.4万股 | +57.4万股+62.08% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #61 | $789.5万 | 138.3万股 | $1,037.0万 | 187.2万股 | -48.9万股-26.13% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #122 | $772.0万 | 135.2万股 | $602.1万 | 108.7万股 | +26.5万股+24.39% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #116 | $718.2万 | 125.8万股 | $610.8万 | 110.2万股 | +15.5万股+14.09% | 加仓 |
| Tetragon Partners GP Ltd |
| 1.12% | 1.39% | #9 | $709.4万 | 124.2万股 | $716.0万 | 129.2万股 | -5.0万股-3.87% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.03% | — | #39 | $681.8万 | 119.5万股 | $0 | 0股 | +119.5万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $676.6万 | 118.5万股 | $686.2万 | 123.9万股 | -5.4万股-4.34% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #102 | $631.2万 | 110.5万股 | $492.3万 | 88.9万股 | +21.7万股+24.41% | 加仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| <0.01% | <0.01% | #93 | $592.3万 | 103.7万股 | $500.5万 | 90.3万股 | +13.4万股+14.83% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #157 | $559.4万 | 100.4万股 | $160.7万 | 32.4万股 | +68.0万股+210.07% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #121 | $558.5万 | 97.8万股 | $387.1万 | 69.9万股 | +27.9万股+39.97% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.02% | — | #48 | $552.7万 | 96.8万股 | $0 | 0股 | +96.8万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #133 | $525.4万 | 92.0万股 | $491.6万 | 88.7万股 | +3.3万股+3.70% | 加仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.09% | 0.11% | #24 | $513.0万 | 89.8万股 | $505.4万 | 91.2万股 | -1.4万股-1.53% | 减仓 |
| Ishara Investments LP |
| 3.38% | 0.91% | #4 | $468.2万 | 82.0万股 | $96.5万 | 17.4万股 | +64.6万股+370.59% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #64 | $457.1万 | 80.1万股 | $346.3万 | 62.5万股 | +17.5万股+28.06% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #94 | $421.4万 | 73.8万股 | $0 | 0股 | +73.8万股 | 新买入 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.08% | 0.14% | #26 | $419.4万 | 73.5万股 | $731.2万 | 132.0万股 | -58.5万股-44.35% | 减仓 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #83 | $402.7万 | 70.5万股 | $394.1万 | 71.1万股 | -6,089股-0.86% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #103 | $395.0万 | 69.2万股 | $430.6万 | 77.7万股 | -8.5万股-10.99% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #161 | $366.4万 | 64.2万股 | $253.5万 | 45.8万股 | +18.4万股+40.23% | 加仓 |
| Parkman Healthcare Partners LLC |
| 0.37% | 0.39% | #15 | $366.0万 | 64.1万股 | $373.4万 | 67.4万股 | -3.3万股-4.89% | 减仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | 0.01% | #75 | $359.2万 | 62.9万股 | $419.6万 | 75.8万股 | -12.9万股-17.03% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #144 | $355.8万 | 62.3万股 | $718.0万 | 129.6万股 | -67.3万股-51.92% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #112 | $352.0万 | 61.6万股 | $311.4万 | 56.2万股 | +5.4万股+9.66% | 加仓 |
