| 富达投资FMR LLC |
| 0.01% | 0.01% | #46 | $2.03亿 | 912.7万股 | $9,955.0万 | 708.5万股 | +204.1万股+28.81% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.06% | — | #26 | $1.39亿 | 627.3万股 | $0 | 0股 | +627.3万股 | 新买入 |
| Fairmount Funds Management LLC |
| 6.69% | 4.62% | #3 | $1.01亿 | 455.3万股 | $6,397.7万 | 455.3万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.71% | 0.55% | #16 | $8,157.1万 | 367.1万股 | $5,157.9万 | 367.1万股 | 00.00% | 持仓不变 |
| Venrock Adviser, LLC |
| 2.17% | 1.69% | #7 | $7,155.6万 | 322.0万股 | $4,524.6万 | 322.0万股 | 00.00% | 持仓不变 |
| Bellevue 集团Bellevue Group AG |
| 1.43% | 1.17% | #8 | $6,794.9万 | 305.8万股 | $4,919.6万 | 350.2万股 | -44.4万股-12.67% | 减仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 1.19% | — | #11 | $6,349.2万 | 285.7万股 | $0 | 0股 | +285.7万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #81 | $6,224.8万 | 280.1万股 | $3,251.1万 | 231.4万股 | +48.8万股+21.07% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | — | #41 | $6,204.0万 | 279.2万股 | $0 | 0股 | +279.2万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #66 | $5,189.0万 | 233.5万股 | $921.2万 | 65.6万股 | +168.0万股+256.16% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #75 | $4,987.9万 | 224.5万股 | $2,524.3万 | 179.7万股 | +44.8万股+24.94% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.06% | — | #25 | $4,245.8万 | 191.1万股 | $0 | 0股 | +191.1万股 | 新买入 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.1% | — | #23 | $4,104.0万 | 184.7万股 | $0 | 0股 | +184.7万股 | 新买入 |
| Avidity Partners Management LP |
| 6.05% | 3.99% | #4 | $3,779.0万 | 170.1万股 | $1,968.0万 | 140.1万股 | +30.0万股+21.42% | 加仓 |
| Remedium Capital Partners, LLC |
| 7.76% | 7.88% | #2 | $3,505.8万 | 157.8万股 | $2,216.7万 | 157.8万股 | 00.00% | 持仓不变 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 1.19% | 0.45% | #12 | $3,445.6万 | 155.1万股 | $1,119.4万 | 79.7万股 | +75.4万股+94.63% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #64 | $3,261.4万 | 147.5万股 | $21.0万 | 1.6万股 | +145.9万股+9,198.87% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.14% | 0.13% | #20 | $2,734.0万 | 123.0万股 | $2,305.8万 | 164.1万股 | -41.1万股-25.03% | 减仓 |
| Logos Global Management LP |
| 1.08% | 0.28% | #13 | $2,499.8万 | 112.5万股 | $562.0万 | 40.0万股 | +72.5万股+181.25% | 加仓 |
| Versant Venture Management, LLC |
| 13.55% | 15.16% | #1 | $2,203.7万 | 99.2万股 | $2,143.8万 | 152.6万股 | -53.4万股-35.00% | 减仓 |
| ACORN CAPITAL ADVISORS, LLC |
| 5.98% | 3.14% | #5 | $2,192.6万 | 98.7万股 | $1,105.4万 | 78.7万股 | +20.0万股+25.42% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #74 | $2,189.7万 | 98.5万股 | $1,155.9万 | 82.3万股 | +16.3万股+19.78% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #57 | $2,065.1万 | 92.9万股 | $192.8万 | 13.7万股 | +79.2万股+577.30% | 加仓 |
| Foresite Capital Management VI LLC |
| 3.07% | 0.98% | #6 | $1,970.2万 | 88.7万股 | $449.6万 | 32.0万股 | +56.7万股+177.08% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #33 | $1,952.5万 | 87.9万股 | $565.5万 | 40.2万股 | +47.6万股+118.32% | 加仓 |
| Affinity Asset Advisors, LLC |
| 0.84% | 0.46% | #15 | $1,867.3万 | 84.0万股 | $899.1万 | 64.0万股 | +20.0万股+31.31% | 加仓 |
| Samsara BioCapital, LLC |
| 1.34% | 1.32% | #9 | $1,635.9万 | 73.6万股 | $1,361.2万 | 96.9万股 | -23.3万股-24.01% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #69 | $1,633.7万 | 73.5万股 | $215.0万 | 15.3万股 | +58.2万股+380.42% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.02% | — | #38 | $1,630.4万 | 73.4万股 | $0 | 0股 | +73.4万股 | 新买入 |
| 安本标准投资Aberdeen Group plc |
| 0.02% | 0.02% | #35 | $1,380.1万 | 62.1万股 | $1,218.5万 | 86.7万股 | -24.6万股-28.38% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.01% | #43 | $1,301.6万 | 58.6万股 | $1,327.4万 | 94.5万股 | -35.9万股-38.00% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #86 | $1,082.0万 | 48.7万股 | $54.2万 | 3.9万股 | +44.8万股+1,161.61% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #96 | $1,025.5万 | 46.2万股 | $296.9万 | 21.1万股 | +25.0万股+118.40% | 加仓 |
| 黑石集团Blackstone Inc. |
| 0.03% | — | #31 | $967.3万 | 43.5万股 | $0 | 0股 | +43.5万股 | 新买入 |
| Ikarian Capital, LLC |
| 1.01% | 0.58% | #14 | $949.6万 | 42.7万股 | $719.9万 | 51.2万股 | -8.5万股-16.59% | 减仓 |
| Walleye资本Walleye Capital LLC |
| 0.03% | — | #32 | $811.6万 | 36.5万股 | $0 | 0股 | +36.5万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #56 | $698.9万 | 31.5万股 | $224.9万 | 16.0万股 | +15.4万股+96.53% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $677.4万 | 30.5万股 | $308.4万 | 21.9万股 | +8.5万股+38.89% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #82 | $655.7万 | 29.5万股 | $339.9万 | 24.2万股 | +5.3万股+21.98% | 加仓 |
| LORD, ABBETT & CO. LLC |
| 0.01% | — | #39 | $503.5万 | 22.7万股 | $0 | 0股 | +22.7万股 | 新买入 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #44 | $482.5万 | 21.7万股 | $237.5万 | 16.9万股 | +4.8万股+28.46% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #61 | $443.1万 | 19.9万股 | $40.2万 | 2.9万股 | +17.1万股+596.72% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| 0.03% | <0.01% | #30 | $383.8万 | 17.3万股 | $16.6万 | 1.2万股 | +16.1万股+1,363.96% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | 0.01% | #51 | $371.5万 | 16.7万股 | $402.8万 | 28.7万股 | -12.0万股-41.68% | 减仓 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #54 | $362.4万 | 16.3万股 | $151.2万 | 10.8万股 | +5.5万股+51.57% | 加仓 |
| Opaleye Management Inc. |
| 0.29% | 0.79% | #18 | $322.2万 | 14.5万股 | $600.8万 | 42.8万股 | -28.3万股-66.09% | 减仓 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #59 | $311.5万 | 14.1万股 | $52.1万 | 3.9万股 | +10.2万股+258.68% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #100 | $283.5万 | 12.8万股 | $91.4万 | 6.5万股 | +6.3万股+96.21% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #114 | $276.7万 | 12.5万股 | $46.8万 | 5.4万股 | +7.0万股+129.56% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #112 | $260.7万 | 11.7万股 | $106.7万 | 7.6万股 | +4.1万股+54.59% | 加仓 |
