| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 3.39% | 4.95% | #7 | $3.90亿 | 1,219.9万股 | $4.67亿 | 1,219.9万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| 0.01% | 0.02% | #47 | $2.85亿 | 892.1万股 | $2.97亿 | 774.8万股 | +117.3万股+15.14% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.06% | — | #28 | $1.39亿 | 435.2万股 | $0 | 0股 | +435.2万股 | 新买入 |
| Alta Partners Management Company, L.P. |
| 95.92% | 96.97% | #1 | $1.22亿 | 382.3万股 | $1.46亿 | 382.3万股 | 00.00% | 持仓不变 |
| Nextech Invest Ltd. |
| 5.41% | 10.93% | #4 | $1.14亿 | 355.4万股 | $1.55亿 | 405.6万股 | -50.2万股-12.38% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 2.49% | 3.56% | #9 | $1.04亿 | 324.9万股 | $1.24亿 | 324.9万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #85 | $9,684.1万 | 303.2万股 | $8,494.7万 | 221.8万股 | +81.4万股+36.70% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #53 | $8,887.5万 | 278.3万股 | $3,776.7万 | 98.6万股 | +179.7万股+182.19% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #78 | $6,836.3万 | 214.0万股 | $4,657.6万 | 121.6万股 | +92.4万股+76.01% | 加仓 |
| Commodore Capital LP |
| 3.57% | 5.48% | #6 | $5,988.8万 | 187.5万股 | $9,479.3万 | 247.5万股 | -60.0万股-24.24% | 减仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 1.09% | 1.61% | #16 | $5,840.6万 | 182.9万股 | $7,870.6万 | 205.5万股 | -22.6万股-11.02% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #96 | $4,818.0万 | 150.8万股 | $4,312.5万 | 112.6万股 | +38.2万股+33.97% | 加仓 |
| BVF INC/IL |
| 1.21% | 2.41% | #14 | $4,715.0万 | 147.6万股 | $7,568.8万 | 197.6万股 | -50.0万股-25.30% | 减仓 |
| 5AM Venture Management, LLC |
| 11.42% | 10.94% | #3 | $3,287.6万 | 102.9万股 | $3,942.2万 | 102.9万股 | 00.00% | 持仓不变 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.34% | 0.25% | #18 | $3,248.3万 | 101.7万股 | $2,102.7万 | 54.9万股 | +46.8万股+85.25% | 加仓 |
| Hood River资本管理Hood River Capital Management LLC |
| 0.24% | — | #20 | $3,247.6万 | 101.7万股 | $0 | 0股 | +101.7万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #81 | $3,101.0万 | 97.1万股 | $2,522.6万 | 65.8万股 | +31.2万股+47.42% | 加仓 |
| Caligan Partners LP |
| 1.21% | 3.25% | #13 | $2,577.5万 | 80.7万股 | $4,890.8万 | 127.7万股 | -47.0万股-36.80% | 减仓 |
| Canaan Partners XI LLC |
| 18.82% | 37.76% | #2 | $2,395.5万 | 75.0万股 | $2,872.5万 | 75.0万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 0.47% | — | #17 | $2,315.7万 | 72.5万股 | $0 | 0股 | +72.5万股 | 新买入 |
| Sio Capital Management, LLC |
| 3.68% | 3.33% | #5 | $2,220.8万 | 69.5万股 | $2,318.8万 | 60.5万股 | +9.0万股+14.84% | 加仓 |
| STEMPOINT CAPITAL LP |
| 2.88% | 1.42% | #8 | $2,021.0万 | 63.3万股 | $768.9万 | 29.3万股 | +34.0万股+115.83% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.01% | #45 | $1,862.5万 | 58.3万股 | $757.4万 | 19.8万股 | +38.5万股+194.89% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #87 | $1,480.3万 | 46.3万股 | $2,107.8万 | 55.0万股 | -8.7万股-15.78% | 减仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.01% | 0.02% | #54 | $1,440.4万 | 45.1万股 | $2,422.2万 | 63.2万股 | -18.1万股-28.69% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #50 | $1,436.7万 | 45.0万股 | $389.2万 | 10.2万股 | +34.8万股+342.65% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #112 | $1,287.2万 | 40.3万股 | $947.0万 | 24.7万股 | +15.6万股+62.99% | 加仓 |
| Defilade Capital Management, L.P. |
| 1.61% | — | #11 | $1,203.7万 | 37.7万股 | $0 | 0股 | +37.7万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #105 | $1,117.0万 | 35.0万股 | $804.0万 | 21.0万股 | +14.0万股+66.60% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.04% | <0.01% | #33 | $1,111.2万 | 34.8万股 | $71.7万 | 1.9万股 | +32.9万股+1,758.93% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | 0.04% | #36 | $1,022.2万 | 32.0万股 | $1,153.0万 | 30.1万股 | +1.9万股+6.31% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #91 | $990.4万 | 31.0万股 | $836.9万 | 21.9万股 | +9.2万股+41.91% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #120 | $959.2万 | 30.0万股 | $450.7万 | 32.2万股 | -2.2万股-6.77% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #102 | $956.6万 | 30.0万股 | $261.4万 | 6.8万股 | +23.1万股+338.87% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #97 | $888.9万 | 27.8万股 | $183.1万 | 4.8万股 | +23.1万股+482.28% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #92 | $855.0万 | 26.8万股 | $762.6万 | 19.9万股 | +6.9万股+34.45% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | — | #57 | $852.6万 | 26.7万股 | $0 | 0股 | +26.7万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #63 | $767.3万 | 24.0万股 | $727.8万 | 19.0万股 | +5.0万股+26.41% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.09% | 0.11% | #23 | $763.7万 | 23.9万股 | $720.1万 | 18.8万股 | +5.1万股+27.18% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #83 | $718.0万 | 22.5万股 | $604.3万 | 15.8万股 | +6.7万股+42.47% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #88 | $693.3万 | 21.7万股 | $351.7万 | 9.2万股 | +12.5万股+136.40% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #76 | $647.3万 | 20.3万股 | $1,001.9万 | 26.2万股 | -5.9万股-22.52% | 减仓 |
| Affinity Asset Advisors, LLC |
| 0.29% | 0.51% | #19 | $638.8万 | 20.0万股 | $986.3万 | 25.8万股 | -5.8万股-22.33% | 减仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #89 | $614.3万 | 19.2万股 | $49.7万 | 1.3万股 | +17.9万股+1,382.96% | 加仓 |
| HighVista Strategies LLC |
| 1.35% | 1.39% | #12 | $590.2万 | 18.5万股 | $502.9万 | 13.1万股 | +5.3万股+40.72% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #84 | $577.7万 | 18.1万股 | $946.4万 | 24.7万股 | -6.6万股-26.80% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #129 | $574.4万 | 17.8万股 | $231.1万 | 6.7万股 | +11.1万股+166.90% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.07% | 0.14% | #26 | $554.3万 | 17.4万股 | $1,046.6万 | 27.3万股 | -10.0万股-36.49% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | — | #60 | $517.4万 | 16.2万股 | $0 | 0股 | +16.2万股 | 新买入 |
| 跳跃金融Jump Financial, LLC |
| 0.04% | 0.02% | #32 | $501.5万 | 15.7万股 | $158.5万 | 4.1万股 | +11.6万股+279.46% | 加仓 |
