| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #82 | $2.11亿 | 2,067.8万股 | $1.61亿 | 1,799.8万股 | +268.0万股+14.89% | 加仓 |
| ARCH Venture Management, LLC |
| 11.76% | 17.09% | #2 | $1.29亿 | 1,269.4万股 | $1.16亿 | 1,291.7万股 | -22.3万股-1.72% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #68 | $1.17亿 | 1,149.5万股 | $8,257.2万 | 921.6万股 | +228.0万股+24.74% | 加仓 |
| SB投资顾问(英国)SB INVESTMENT ADVISERS (UK) LTD |
| 1.46% | 1.27% | #7 | $1.12亿 | 1,094.8万股 | $9,809.5万 | 1,094.8万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #86 | $1.02亿 | 996.4万股 | $6,398.4万 | 714.1万股 | +282.3万股+39.53% | 加仓 |
| GSK plc |
| 14.47% | 12.79% | #1 | $8,713.4万 | 855.1万股 | $7,661.7万 | 855.1万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #120 | $6,510.2万 | 638.9万股 | $4,822.4万 | 538.2万股 | +100.7万股+18.70% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.06% | 0.02% | #22 | $5,774.5万 | 566.7万股 | $1,749.2万 | 195.2万股 | +371.5万股+190.27% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #111 | $3,412.5万 | 334.8万股 | $2,382.0万 | 265.8万股 | +69.1万股+25.98% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #66 | $3,179.0万 | 311.9万股 | $2,310.7万 | 258.0万股 | +54.0万股+20.92% | 加仓 |
| ADAR1 Capital Management, LLC |
| 1.15% | 1.45% | #10 | $2,503.4万 | 245.7万股 | $2,459.3万 | 274.5万股 | -28.8万股-10.49% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #106 | $2,410.2万 | 236.5万股 | $2,912.2万 | 325.0万股 | -88.5万股-27.23% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #138 | $2,362.3万 | 231.8万股 | $1,856.4万 | 207.2万股 | +24.6万股+11.89% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #131 | $2,253.1万 | 221.1万股 | $1,535.5万 | 268.9万股 | -47.8万股-17.78% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #73 | $2,020.6万 | 198.3万股 | $913.0万 | 101.9万股 | +96.4万股+94.60% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.02% | 0.01% | #41 | $1,990.4万 | 195.3万股 | $1,326.8万 | 148.1万股 | +47.2万股+31.91% | 加仓 |
| Boxer Capital Management, LLC |
| 1.43% | 2.2% | #8 | $1,901.5万 | 186.6万股 | $1,671.9万 | 186.6万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #113 | $1,459.4万 | 143.2万股 | $882.9万 | 98.5万股 | +44.7万股+45.33% | 加仓 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| 0.04% | 0.05% | #33 | $1,389.9万 | 136.4万股 | $1,316.7万 | 147.0万股 | -10.6万股-7.18% | 减仓 |
| GordonMD Global Investments LP |
| 5.46% | 9.48% | #4 | $1,379.3万 | 135.4万股 | $1,360.6万 | 151.9万股 | -16.5万股-10.87% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #112 | $1,348.3万 | 132.3万股 | $1,049.8万 | 117.2万股 | +15.2万股+12.93% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #146 | $1,164.2万 | 114.3万股 | $865.4万 | 96.6万股 | +17.7万股+18.30% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #59 | $1,131.3万 | 111.0万股 | $1,289.8万 | 143.9万股 | -32.9万股-22.87% | 减仓 |
| Sio Capital Management, LLC |
| 1.81% | 1.93% | #6 | $1,095.7万 | 107.5万股 | $1,342.8万 | 149.9万股 | -42.3万股-28.25% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #129 | $1,064.5万 | 104.5万股 | $1,974.7万 | 220.4万股 | -115.9万股-52.60% | 减仓 |
| Savvy Advisors, Inc. |
| 0.23% | — | #17 | $1,060.4万 | 104.1万股 | $0 | 0股 | +104.1万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #50 | $1,036.2万 | 101.7万股 | $682.2万 | 76.1万股 | +25.6万股+33.56% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.35% | 0.73% | #16 | $1,019.0万 | 100.0万股 | $1,793.8万 | 200.2万股 | -100.2万股-50.05% | 减仓 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 5.49% | 4.68% | #3 | $869.9万 | 85.4万股 | $654.6万 | 73.1万股 | +12.3万股+16.86% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #110 | $857.5万 | 84.2万股 | $655.6万 | 73.2万股 | +11.0万股+15.01% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | 0.02% | #51 | $849.6万 | 83.4万股 | $959.4万 | 107.1万股 | -23.7万股-22.14% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #160 | $833.1万 | 80.3万股 | $945.4万 | 111.8万股 | -31.5万股-28.18% | 减仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.1% | 0.07% | #18 | $820.3万 | 80.5万股 | $438.2万 | 48.9万股 | +31.6万股+64.61% | 加仓 |
| Saturn V Capital Management LP |
| 1.13% | — | #11 | $785.3万 | 77.1万股 | $0 | 0股 | +77.1万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #133 | $707.6万 | 69.4万股 | $523.3万 | 58.4万股 | +11.0万股+18.89% | 加仓 |
| Jones Hill Capital LP |
| 1.43% | 2.3% | #9 | $671.7万 | 65.9万股 | $1,073.6万 | 119.8万股 | -53.9万股-44.98% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #80 | $666.1万 | 65.4万股 | $965.9万 | 107.8万股 | -42.4万股-39.36% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #65 | $653.7万 | 64.1万股 | $1,118.8万 | 124.9万股 | -60.7万股-48.63% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.03% | 0.03% | #36 | $638.0万 | 62.7万股 | $622.1万 | 103.2万股 | -40.5万股-39.25% | 减仓 |
| Clearstead顾问Clearstead Advisors, LLC |
| 0.06% | 0.1% | #25 | $619.8万 | 60.8万股 | $1,089.9万 | 121.6万股 | -60.8万股-50.00% | 减仓 |
| 北欧投资管理NORDEA INVESTMENT MANAGEMENT AB |
| <0.01% | <0.01% | #72 | $609.8万 | 59.4万股 | $509.3万 | 58.1万股 | +1.3万股+2.24% | 加仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| <0.01% | <0.01% | #88 | $598.0万 | 58.7万股 | $490.8万 | 54.8万股 | +3.9万股+7.15% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #107 | $592.5万 | 58.1万股 | $507.1万 | 56.6万股 | +1.5万股+2.72% | 加仓 |
| 韦斯资产管理Weiss Asset Management LP |
| 0.06% | — | #23 | $566.1万 | 55.6万股 | $0 | 0股 | +55.6万股 | 新买入 |
| Avidity Partners Management LP |
| 0.85% | 1.72% | #13 | $529.2万 | 51.9万股 | $851.2万 | 95.0万股 | -43.1万股-45.34% | 减仓 |
| Walleye资本Walleye Capital LLC |
| 0.02% | 0.02% | #42 | $528.6万 | 51.9万股 | $600.2万 | 67.0万股 | -15.1万股-22.56% | 减仓 |
| Alta Partners Management Company, L.P. |
| 4.08% | 3.03% | #5 | $519.6万 | 51.0万股 | $456.9万 | 51.0万股 | 00.00% | 持仓不变 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #171 | $484.6万 | 47.6万股 | $377.5万 | 42.1万股 | +5.4万股+12.87% | 加仓 |
| Parkman Healthcare Partners LLC |
| 0.5% | 0.46% | #14 | $484.3万 | 47.5万股 | $448.0万 | 50.0万股 | -2.5万股-4.94% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #154 | $470.1万 | 46.1万股 | $666.8万 | 74.4万股 | -28.3万股-38.00% | 减仓 |
