| RTW投资RTW INVESTMENTS, LP |
| 1.43% | 0.81% | #8 | $1.67亿 | 454.4万股 | $8,169.9万 | 454.4万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #91 | $1.18亿 | 320.1万股 | $5,116.3万 | 284.6万股 | +35.6万股+12.51% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #61 | $9,481.0万 | 257.6万股 | $5,044.2万 | 252.8万股 | +4.8万股+1.90% | 加仓 |
| Kynam Capital Management, LP |
| 4.95% | 2.49% | #3 | $8,957.9万 | 243.4万股 | $4,040.8万 | 224.7万股 | +18.7万股+8.31% | 加仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.53% | 0.27% | #16 | $8,094.7万 | 220.0万股 | $3,955.0万 | 220.0万股 | 00.00% | 持仓不变 |
| SG Americas Securities, LLC |
| 0.04% | 0.03% | #39 | $7,554.7万 | 205.3万股 | $2,980.8万 | 165.8万股 | +39.5万股+23.83% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.03% | 0.02% | #41 | $6,203.5万 | 168.6万股 | $2,944.4万 | 163.8万股 | +4.8万股+2.94% | 加仓 |
| ACORN CAPITAL ADVISORS, LLC |
| 16.8% | 8.55% | #1 | $6,158.2万 | 167.3万股 | $3,008.8万 | 167.3万股 | 00.00% | 持仓不变 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.06% | — | #36 | $5,614.0万 | 152.6万股 | $0 | 0股 | +152.6万股 | 新买入 |
| Frontier资本管理FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.52% | 0.24% | #17 | $5,551.5万 | 150.9万股 | $2,362.8万 | 131.4万股 | +19.4万股+14.80% | 加仓 |
| Opaleye Management Inc. |
| 4.8% | 3.39% | #4 | $5,299.2万 | 144.0万股 | $2,571.1万 | 143.0万股 | +9,996股+0.70% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 4.98% | 2.76% | #2 | $4,791.3万 | 130.2万股 | $2,702.5万 | 150.3万股 | -20.1万股-13.38% | 减仓 |
| Menora Mivtachim控股MENORA MIVTACHIM HOLDINGS LTD. |
| 0.17% | 0.1% | #30 | $4,241.3万 | 115.3万股 | $2,072.3万 | 115.3万股 | 00.00% | 持仓不变 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.02% | 0.01% | #46 | $4,216.6万 | 114.6万股 | $1,839.6万 | 102.3万股 | +12.3万股+11.99% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #106 | $3,691.3万 | 100.3万股 | $1,571.8万 | 87.4万股 | +12.9万股+14.74% | 加仓 |
| MPM BioImpact LLC |
| 2.09% | 1.31% | #7 | $3,435.0万 | 93.3万股 | $1,697.0万 | 94.4万股 | -1.0万股-1.10% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 1.05% | 0.53% | #12 | $3,053.7万 | 83.0万股 | $1,307.1万 | 72.7万股 | +10.3万股+14.14% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #79 | $3,017.0万 | 82.0万股 | $1,076.2万 | 59.9万股 | +22.1万股+36.98% | 加仓 |
| 以色列Migdal保险金融控股Migdal Insurance & Financial Holdings Ltd. |
| 0.18% | 0.12% | #27 | $2,836.9万 | 77.1万股 | $1,386.1万 | 77.1万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.47% | 0.31% | #19 | $2,488.4万 | 67.6万股 | $1,574.1万 | 87.5万股 | -19.9万股-22.76% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #104 | $2,246.1万 | 61.0万股 | $941.8万 | 52.4万股 | +8.7万股+16.52% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.06% | 0.03% | #37 | $1,842.7万 | 50.1万股 | $900.3万 | 50.1万股 | 00.00% | 持仓不变 |
| Boxer Capital Management, LLC |
| 1.39% | 1.18% | #10 | $1,840.0万 | 50.0万股 | $899.0万 | 50.0万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #105 | $1,750.6万 | 47.6万股 | $228.0万 | 12.7万股 | +34.9万股+275.21% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #118 | $1,680.1万 | 45.7万股 | $736.4万 | 41.0万股 | +4.7万股+11.48% | 加仓 |
| 安大略医疗养老基金(HOOPP)HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.02% | 0.01% | #47 | $1,424.4万 | 38.7万股 | $696.0万 | 38.7万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #100 | $1,120.8万 | 30.5万股 | $496.1万 | 27.6万股 | +2.9万股+10.38% | 加仓 |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 0.54% | 0.29% | #15 | $1,106.4万 | 30.1万股 | $513.9万 | 28.6万股 | +1.5万股+5.18% | 加仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.29% | 0.11% | #21 | $1,018.2万 | 27.7万股 | $329.9万 | 18.4万股 | +9.3万股+50.78% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #116 | $986.5万 | 26.8万股 | $570.7万 | 31.7万股 | -4.9万股-15.54% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.43% | 0.42% | #20 | $928.8万 | 25.2万股 | $711.0万 | 39.5万股 | -14.3万股-36.18% | 减仓 |
| J. Goldman & Co LP |
| 0.23% | 0.52% | #24 | $908.1万 | 24.7万股 | $1,778.0万 | 98.9万股 | -74.2万股-75.04% | 减仓 |
| Privium Fund Management B.V. |
| 1.42% | 0.89% | #9 | $772.8万 | 21.0万股 | $428.1万 | 23.8万股 | -2.8万股-11.81% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #140 | $725.3万 | 19.7万股 | $260.6万 | 14.5万股 | +5.2万股+35.97% | 加仓 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 4.44% | 4.98% | #5 | $704.0万 | 19.1万股 | $696.5万 | 38.7万股 | -19.6万股-50.61% | 减仓 |
| Parkman Healthcare Partners LLC |
| 0.66% | 0.51% | #14 | $640.6万 | 17.4万股 | $494.5万 | 27.5万股 | -10.1万股-36.70% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #90 | $549.2万 | 14.9万股 | $259.0万 | 14.4万股 | +5,168股+3.59% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #64 | $548.2万 | 14.9万股 | $319.9万 | 17.8万股 | -2.9万股-16.27% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #124 | $472.4万 | 12.8万股 | $159.1万 | 8.8万股 | +4.0万股+45.11% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #126 | $447.0万 | 12.1万股 | $287.1万 | 16.0万股 | -3.8万股-23.92% | 减仓 |
| Elmind Capital, LP |
| 1.11% | 1.12% | #11 | $441.6万 | 12.0万股 | $395.6万 | 22.0万股 | -10.0万股-45.45% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #120 | $424.5万 | 11.5万股 | $180.2万 | 10.0万股 | +1.5万股+15.11% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #122 | $415.9万 | 11.3万股 | $177.9万 | 9.9万股 | +1.4万股+14.24% | 加仓 |
| Voloridge投资管理VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.02% | 0.02% | #49 | $409.0万 | 11.1万股 | $414.7万 | 23.1万股 | -11.9万股-51.81% | 减仓 |
| Aisling Capital Management LP |
| 0.84% | 0.41% | #13 | $397.4万 | 10.8万股 | $194.2万 | 10.8万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #99 | $392.6万 | 10.7万股 | $666.9万 | 37.1万股 | -26.4万股-71.23% | 减仓 |
| Tidal投资Tidal Investments LLC |
| 0.01% | <0.01% | #59 | $374.8万 | 10.2万股 | $185.1万 | 10.3万股 | -1,112股-1.08% | 减仓 |
| ARK投资管理ARK Investment Management LLC |
| 0.02% | 0.02% | #42 | $373.5万 | 10.2万股 | $207.7万 | 11.6万股 | -1.4万股-12.15% | 减仓 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #77 | $349.5万 | 9.5万股 | $113.7万 | 6.3万股 | +3.2万股+50.17% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #114 | $338.9万 | 9.2万股 | $157.4万 | 8.8万股 | +4,580股+5.23% | 加仓 |
