| 富达投资FMR LLC |
| 0.01% | 0.01% | #53 | $1.52亿 | 1,214.3万股 | $1.55亿 | 1,038.7万股 | +175.6万股+16.91% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 2.03% | 2.44% | #2 | $1.08亿 | 867.1万股 | $1.20亿 | 802.1万股 | +65.0万股+8.10% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.04% | — | #32 | $8,880.3万 | 709.4万股 | $0 | 0股 | +709.4万股 | 新买入 |
| Bain Capital Life Sciences Investors, LLC |
| 5.27% | 10.05% | #1 | $8,863.6万 | 708.5万股 | $1.11亿 | 747.3万股 | -38.8万股-5.19% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #83 | $8,400.1万 | 671.5万股 | $8,427.3万 | 565.2万股 | +106.3万股+18.80% | 加仓 |
| BVF INC/IL |
| 1.69% | 2.52% | #4 | $6,625.2万 | 529.6万股 | $7,896.2万 | 529.6万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 1.23% | 1.97% | #9 | $6,076.0万 | 485.7万股 | $7,092.6万 | 475.7万股 | +10.0万股+2.10% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #76 | $5,399.4万 | 431.6万股 | $5,871.3万 | 393.8万股 | +37.8万股+9.60% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #99 | $4,179.9万 | 334.1万股 | $4,597.5万 | 308.4万股 | +25.8万股+8.36% | 加仓 |
| Logos Global Management LP |
| 1.73% | 2.39% | #3 | $4,014.3万 | 320.9万股 | $4,784.4万 | 320.9万股 | 00.00% | 持仓不变 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #54 | $2,939.3万 | 235.0万股 | $1,817.5万 | 121.9万股 | +113.1万股+92.75% | 加仓 |
| Cormorant Asset Management, LP |
| 1.37% | 3.29% | #8 | $2,689.7万 | 215.0万股 | $6,560.4万 | 440.0万股 | -225.0万股-51.14% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #85 | $2,292.2万 | 183.2万股 | $1,523.2万 | 155.6万股 | +27.6万股+17.76% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #84 | $2,276.0万 | 181.9万股 | $2,303.1万 | 154.4万股 | +27.5万股+17.78% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #97 | $2,080.7万 | 166.3万股 | $884.2万 | 59.3万股 | +107.0万股+180.46% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #74 | $1,961.5万 | 156.8万股 | $1,867.8万 | 125.3万股 | +31.5万股+25.17% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.27% | — | #16 | $1,876.5万 | 150.0万股 | $0 | 0股 | +150.0万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #61 | $1,771.8万 | 141.7万股 | $1,613.4万 | 108.2万股 | +33.4万股+30.87% | 加仓 |
| Lightspeed Management Company, L.L.C. |
| 0.71% | 2.05% | #13 | $1,695.5万 | 135.5万股 | $2,020.8万 | 135.5万股 | 00.00% | 持仓不变 |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 1.54% | 1.4% | #6 | $1,501.2万 | 120.0万股 | $1,274.8万 | 85.5万股 | +34.5万股+40.35% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #48 | $1,415.4万 | 113.1万股 | $1,743.6万 | 116.9万股 | -3.8万股-3.25% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.02% | <0.01% | #42 | $1,367.8万 | 109.3万股 | $163.6万 | 11.0万股 | +98.4万股+896.61% | 加仓 |
| 杜肯家族办公室Duquesne Family Office LLC |
| 0.24% | 0.44% | #17 | $1,234.5万 | 98.7万股 | $1,471.4万 | 98.7万股 | 00.00% | 持仓不变 |
| Defilade Capital Management, L.P. |
| 1.55% | 3.15% | #5 | $1,156.9万 | 92.5万股 | $2,243.3万 | 150.5万股 | -58.0万股-38.54% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #71 | $1,051.6万 | 84.1万股 | $85.5万 | 5.7万股 | +78.3万股+1,365.51% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #91 | $1,034.0万 | 82.7万股 | $1,763.7万 | 118.3万股 | -35.6万股-30.12% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | 0.08% | #36 | $939.5万 | 75.1万股 | $2,209.7万 | 148.2万股 | -73.1万股-49.32% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.04% | 0.08% | #31 | $938.8万 | 75.1万股 | $1,698.8万 | 67.9万股 | +7.2万股+10.54% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #90 | $907.8万 | 72.6万股 | $1,649.5万 | 110.6万股 | -38.1万股-34.41% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #93 | $844.4万 | 67.5万股 | $849.8万 | 57.0万股 | +10.5万股+18.42% | 加仓 |
| Vivo Capital, LLC |
| 0.77% | 0.83% | #12 | $840.5万 | 67.2万股 | $1,001.7万 | 67.2万股 | 00.00% | 持仓不变 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #51 | $829.8万 | 66.3万股 | $466.4万 | 31.3万股 | +35.1万股+112.05% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.01% | 0.02% | #50 | $770.0万 | 61.5万股 | $1,280.1万 | 85.9万股 | -24.3万股-28.31% | 减仓 |
| Ikarian Capital, LLC |
| 0.77% | 1.39% | #11 | $729.7万 | 58.3万股 | $1,711.8万 | 114.8万股 | -56.5万股-49.20% | 减仓 |
| Jones Hill Capital LP |
| 1.53% | — | #7 | $718.3万 | 57.4万股 | $0 | 0股 | +57.4万股 | 新买入 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| 0.02% | 0.01% | #37 | $708.6万 | 56.6万股 | $230.8万 | 15.5万股 | +41.2万股+265.96% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #88 | $658.6万 | 52.6万股 | $991.0万 | 66.5万股 | -13.8万股-20.80% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #101 | $648.4万 | 51.8万股 | $695.6万 | 46.7万股 | +5.2万股+11.10% | 加仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.15% | 0.24% | #19 | $525.7万 | 42.0万股 | $717.9万 | 48.1万股 | -6.1万股-12.73% | 减仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.12% | 0.18% | #21 | $523.6万 | 41.9万股 | $639.0万 | 42.9万股 | -1.0万股-2.33% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #87 | $519.2万 | 41.5万股 | $534.2万 | 35.8万股 | +5.7万股+15.84% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #125 | $514.1万 | 41.1万股 | $1,800.2万 | 120.7万股 | -79.6万股-65.96% | 减仓 |
| SEB资产管理SEB Asset Management AB |
| 0.02% | 0.02% | #41 | $424.7万 | 33.9万股 | $506.1万 | 33.9万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #137 | $418.9万 | 33.5万股 | $758.5万 | 50.9万股 | -17.4万股-34.17% | 减仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| <0.01% | <0.01% | #89 | $371.2万 | 29.7万股 | $446.9万 | 30.0万股 | -3,032股-1.01% | 减仓 |
| Rock Springs Capital Management LP |
| 0.14% | 0.15% | #20 | $294.2万 | 23.5万股 | $254.0万 | 17.0万股 | +6.5万股+38.03% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #127 | $278.8万 | 22.3万股 | $574.1万 | 38.5万股 | -16.2万股-42.12% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #121 | $277.9万 | 22.2万股 | $288.5万 | 19.3万股 | +2.9万股+14.83% | 加仓 |
| Pier Capital, LLC |
| 0.37% | 0.33% | #15 | $276.1万 | 22.1万股 | $202.9万 | 13.6万股 | +8.5万股+62.15% | 加仓 |
| Birchview Capital, LP |
| 1.13% | 1.86% | #10 | $248.9万 | 19.9万股 | $326.5万 | 21.9万股 | -2.0万股-9.13% | 减仓 |
