| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 2.17% | 2.73% | #7 | $1.19亿 | 829.6万股 | $1.07亿 | 829.6万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #91 | $1.07亿 | 746.3万股 | $9,251.6万 | 717.7万股 | +28.6万股+3.98% | 加仓 |
| Cormorant Asset Management, LP |
| 5.08% | 5.35% | #3 | $1.00亿 | 700.0万股 | $1.07亿 | 826.5万股 | -126.5万股-15.31% | 减仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.12% | 0.12% | #29 | $8,123.9万 | 568.1万股 | $7,308.1万 | 567.0万股 | +1.1万股+0.20% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.1% | 0.07% | #32 | $6,903.7万 | 482.8万股 | $4,253.7万 | 330.0万股 | +152.8万股+46.30% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #54 | $6,874.1万 | 480.7万股 | $6,507.6万 | 504.9万股 | -24.2万股-4.78% | 减仓 |
| Commodore Capital LP |
| 3.92% | 2.11% | #5 | $6,578.0万 | 460.0万股 | $3,641.4万 | 282.5万股 | +177.5万股+62.83% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #48 | $5,389.8万 | 377.0万股 | $0 | 0股 | +377.0万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #109 | $5,191.3万 | 363.0万股 | $4,588.3万 | 356.0万股 | +7.1万股+1.99% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 0.77% | 0.83% | #16 | $4,133.3万 | 289.0万股 | $4,050.6万 | 314.2万股 | -25.2万股-8.02% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #113 | $3,371.3万 | 235.8万股 | $2,703.3万 | 209.7万股 | +26.0万股+12.41% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #70 | $3,219.7万 | 225.2万股 | $2,584.8万 | 200.5万股 | +24.6万股+12.28% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #92 | $2,949.7万 | 206.2万股 | $2,557.4万 | 198.4万股 | +7.9万股+3.97% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.04% | 0.04% | #42 | $2,872.6万 | 200.9万股 | $2,240.8万 | 173.8万股 | +27.0万股+15.56% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.43% | — | #20 | $2,860.0万 | 200.0万股 | $0 | 0股 | +200.0万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.02% | #46 | $2,591.7万 | 181.2万股 | $1,854.5万 | 143.9万股 | +37.4万股+25.97% | 加仓 |
| Parkman Healthcare Partners LLC |
| 1.89% | 1.8% | #9 | $1,842.1万 | 128.8万股 | $1,746.3万 | 135.5万股 | -6.7万股-4.92% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.24% | 0.27% | #22 | $1,781.2万 | 124.6万股 | $1,605.6万 | 124.6万股 | 00.00% | 持仓不变 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #57 | $1,689.0万 | 118.1万股 | $554.7万 | 43.0万股 | +75.1万股+174.48% | 加仓 |
| Essex Woodlands Management, Inc. |
| 6.1% | 5.58% | #1 | $1,551.3万 | 108.5万股 | $1,398.4万 | 108.5万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.29% | 0.27% | #21 | $1,528.9万 | 106.9万股 | $1,378.1万 | 106.9万股 | 00.00% | 持仓不变 |
| 5AM Venture Management, LLC |
| 5.22% | 3.76% | #2 | $1,501.5万 | 105.0万股 | $1,353.5万 | 105.0万股 | 00.00% | 持仓不变 |
| Rosalind Advisors, Inc. |
| 3.35% | 5.37% | #6 | $1,413.2万 | 98.8万股 | $1,336.4万 | 103.7万股 | -4.9万股-4.68% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #125 | $1,388.6万 | 97.1万股 | $1,023.3万 | 79.4万股 | +17.7万股+22.31% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #80 | $1,213.2万 | 84.8万股 | $545.6万 | 42.3万股 | +42.5万股+100.45% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #84 | $1,203.6万 | 84.2万股 | $516.5万 | 40.1万股 | +44.1万股+109.85% | 加仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | 0.01% | #67 | $1,191.8万 | 83.3万股 | $1,074.3万 | 83.3万股 | 00.00% | 持仓不变 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #114 | $1,130.2万 | 79.0万股 | $892.4万 | 69.2万股 | +9.8万股+14.16% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.05% | 0.06% | #38 | $1,125.4万 | 78.8万股 | $1,232.2万 | 67.4万股 | +11.3万股+16.81% | 加仓 |
| Artia Global Partners LP |
| 2.02% | 1.98% | #8 | $1,097.0万 | 76.7万股 | $988.8万 | 76.7万股 | 00.00% | 持仓不变 |
| Blue Owl Capital Holdings LP |
| 1.59% | 3.16% | #11 | $1,090.5万 | 76.3万股 | $1,176.3万 | 91.3万股 | -15.0万股-16.44% | 减仓 |
| Ikarian Capital, LLC |
| 1.12% | 0.78% | #14 | $1,059.3万 | 74.1万股 | $954.9万 | 74.1万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #104 | $1,030.9万 | 72.1万股 | $872.4万 | 67.7万股 | +4.4万股+6.52% | 加仓 |
| Patient Square Capital LP |
| 1.59% | 1.82% | #10 | $1,029.6万 | 72.0万股 | $1,024.8万 | 79.5万股 | -7.5万股-9.43% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #102 | $926.1万 | 64.8万股 | $825.1万 | 64.0万股 | +7,490股+1.17% | 加仓 |
| Sio Capital Management, LLC |
| 1.47% | 1.33% | #12 | $891.1万 | 62.3万股 | $930.4万 | 72.2万股 | -9.9万股-13.67% | 减仓 |
| Principia Wealth Advisory, LLC |
| 4.62% | — | #4 | $816.6万 | 63.4万股 | $0 | 0股 | +63.4万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #87 | $799.7万 | 55.9万股 | $650.3万 | 50.4万股 | +5.5万股+10.85% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #119 | $765.3万 | 53.5万股 | $992.3万 | 77.0万股 | -23.5万股-30.48% | 减仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.02% | 0.02% | #50 | $728.4万 | 50.9万股 | $656.6万 | 50.9万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #82 | $715.1万 | 50.0万股 | $612.5万 | 47.5万股 | +2.5万股+5.24% | 加仓 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.08% | 0.06% | #34 | $572.1万 | 40.0万股 | $420.4万 | 32.6万股 | +7.4万股+22.66% | 加仓 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| 0.03% | — | #47 | $500.5万 | 35.0万股 | $0 | 0股 | +35.0万股 | 新买入 |
| STEMPOINT CAPITAL LP |
| 0.69% | 1.93% | #17 | $484.0万 | 33.8万股 | $1,045.1万 | 81.1万股 | -47.2万股-58.25% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #148 | $481.5万 | 33.7万股 | $1,392.9万 | 97.8万股 | -64.1万股-65.57% | 减仓 |
| E Fund Management Co., Ltd. |
| 0.11% | 0.04% | #30 | $473.0万 | 33.1万股 | $121.8万 | 9.5万股 | +23.6万股+250.03% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| 0.04% | 0.03% | #44 | $458.7万 | 32.1万股 | $255.7万 | 19.8万股 | +12.2万股+61.67% | 加仓 |
| Bleichroeder LP |
| 0.81% | 0.71% | #15 | $452.6万 | 31.7万股 | $408.0万 | 31.7万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | <0.01% | #56 | $429.7万 | 30.0万股 | $129.5万 | 10.0万股 | +20.0万股+199.08% | 加仓 |
| Eversept Partners, LP |
| 0.22% | — | #25 | $425.8万 | 29.8万股 | $0 | 0股 | +29.8万股 | 新买入 |
