| 富达投资FMR LLC |
| 0.01% | <0.01% | #62 | $2.95亿 | 2,541.0万股 | $6,765.3万 | 2,255.1万股 | +285.9万股+12.68% | 加仓 |
| ARK投资管理ARK Investment Management LLC |
| 0.97% | 0.32% | #7 | $1.50亿 | 1,292.5万股 | $4,117.9万 | 1,372.6万股 | -80.1万股-5.83% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #94 | $1.41亿 | 1,217.5万股 | $3,376.6万 | 1,125.5万股 | +92.0万股+8.17% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #86 | $9,384.8万 | 809.7万股 | $2,197.5万 | 732.5万股 | +77.2万股+10.55% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.02% | <0.01% | #54 | $8,103.5万 | 699.2万股 | $954.0万 | 318.0万股 | +381.2万股+119.86% | 加仓 |
| Redmile Group, LLC |
| 5.24% | 1.64% | #2 | $7,811.3万 | 674.0万股 | $2,476.0万 | 825.3万股 | -151.4万股-18.34% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #106 | $7,096.2万 | 612.3万股 | $0 | 0股 | +612.3万股 | 新买入 |
| ADVANCED MICRO DEVICES INC |
| 5.05% | 9.83% | #3 | $6,622.9万 | 571.4万股 | $1,714.3万 | 571.4万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.09% | — | #29 | $6,611.9万 | 570.5万股 | $0 | 0股 | +570.5万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.05% | 0.01% | #36 | $6,367.0万 | 549.3万股 | $869.6万 | 289.9万股 | +259.5万股+89.51% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.03% | <0.01% | #46 | $6,072.9万 | 524.0万股 | $194.9万 | 65.0万股 | +459.0万股+706.34% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #92 | $4,153.8万 | 358.3万股 | $1,003.1万 | 334.3万股 | +24.0万股+7.18% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.1% | 0.04% | #28 | $3,130.1万 | 270.1万股 | $990.1万 | 330.0万股 | -59.9万股-18.17% | 减仓 |
| Siren, L.L.C. |
| 0.58% | 0.15% | #10 | $2,868.3万 | 247.5万股 | $540.0万 | 180.0万股 | +67.5万股+37.49% | 加仓 |
| BVF INC/IL |
| 0.7% | — | #8 | $2,737.2万 | 236.2万股 | $0 | 0股 | +236.2万股 | 新买入 |
| Gem Investment Advisors, LLC |
| 15.43% | 7.18% | #1 | $2,516.0万 | 217.1万股 | $757.6万 | 217.1万股 | 00.00% | 持仓不变 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.12% | 0.04% | #25 | $2,474.2万 | 213.5万股 | $640.4万 | 213.5万股 | 00.00% | 持仓不变 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #97 | $2,313.4万 | 199.6万股 | $398.1万 | 132.7万股 | +66.9万股+50.41% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $2,007.8万 | 173.2万股 | $177.5万 | 59.2万股 | +114.1万股+192.76% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #69 | $1,998.1万 | 172.4万股 | $102.8万 | 34.3万股 | +138.1万股+403.07% | 加仓 |
| Voloridge投资管理VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.08% | — | #30 | $1,857.8万 | 160.3万股 | $0 | 0股 | +160.3万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #102 | $1,726.9万 | 149.0万股 | $35.3万 | 11.8万股 | +137.2万股+1,167.40% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #124 | $1,593.3万 | 137.5万股 | $294.8万 | 97.0万股 | +40.5万股+41.74% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #134 | $1,551.9万 | 133.9万股 | $0 | 0股 | +133.9万股 | 新买入 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| 0.05% | 0.02% | #37 | $1,363.9万 | 117.7万股 | $349.5万 | 116.5万股 | +1.2万股+1.00% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #98 | $1,351.4万 | 116.6万股 | $325.3万 | 108.4万股 | +8.2万股+7.54% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #103 | $1,319.9万 | 113.9万股 | $479.9万 | 160.0万股 | -46.1万股-28.81% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #107 | $1,288.6万 | 111.2万股 | $307.0万 | 102.3万股 | +8.8万股+8.64% | 加仓 |
| 三井住友信托集团Sumitomo Mitsui Trust Group, Inc. |
| 0.01% | <0.01% | #66 | $1,188.9万 | 102.6万股 | $404.0万 | 134.7万股 | -32.1万股-23.83% | 减仓 |
| Amova资产管理Amova Asset Management Americas, Inc. |
| 0.15% | 0.06% | #22 | $1,174.2万 | 101.4万股 | $404.0万 | 134.7万股 | -33.3万股-24.71% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #88 | $1,129.0万 | 97.4万股 | $0 | 0股 | +97.4万股 | 新买入 |
| Casdin Capital, LLC |
| 0.56% | 0.22% | #11 | $1,128.0万 | 97.3万股 | $292.0万 | 97.3万股 | 00.00% | 持仓不变 |
| Parkman Healthcare Partners LLC |
| 1.06% | 0.58% | #5 | $1,036.6万 | 89.4万股 | $559.4万 | 186.5万股 | -97.0万股-52.04% | 减仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.37% | — | #15 | $927.2万 | 80.0万股 | $0 | 0股 | +80.0万股 | 新买入 |
| 拉扎德资产管理LAZARD ASSET MANAGEMENT LLC |
| 0.01% | <0.01% | #61 | $906.0万 | 78.2万股 | $159.0万 | 53.0万股 | +25.2万股+47.45% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $876.8万 | 75.7万股 | $209.8万 | 69.9万股 | +5.7万股+8.16% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #110 | $695.5万 | 60.0万股 | $180.0万 | 60.0万股 | -271股-0.05% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #152 | $656.0万 | 56.6万股 | $146.2万 | 48.7万股 | +7.9万股+16.18% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #145 | $631.6万 | 54.5万股 | $33.0万 | 11.0万股 | +43.5万股+394.85% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #132 | $629.4万 | 54.3万股 | $179.8万 | 59.9万股 | -5.6万股-9.40% | 减仓 |
| Group One交易GROUP ONE TRADING LLC |
| 0.01% | 0.01% | #65 | $608.2万 | 52.5万股 | $339.6万 | 113.2万股 | -60.7万股-53.64% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #71 | $582.3万 | 50.2万股 | $365.7万 | 121.9万股 | -71.7万股-58.79% | 减仓 |
| Trexquant投资Trexquant Investment LP |
| 0.03% | — | #44 | $558.1万 | 48.2万股 | $0 | 0股 | +48.2万股 | 新买入 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.35% | 0.12% | #16 | $554.6万 | 47.9万股 | $162.4万 | 54.1万股 | -6.3万股-11.58% | 减仓 |
| Artia Global Partners LP |
| 0.99% | — | #6 | $538.3万 | 46.4万股 | $0 | 0股 | +46.4万股 | 新买入 |
| Royce联营ROYCE & ASSOCIATES LP |
| 0.04% | 0.02% | #41 | $516.7万 | 44.6万股 | $220.6万 | 73.5万股 | -29.0万股-39.38% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #125 | $469.5万 | 40.5万股 | $110.0万 | 36.7万股 | +3.8万股+10.44% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #130 | $448.3万 | 38.7万股 | $101.4万 | 33.8万股 | +4.9万股+14.50% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | <0.01% | #68 | $416.2万 | 35.9万股 | $313.6万 | 104.5万股 | -68.6万股-65.64% | 减仓 |
| Ikarian Capital, LLC |
| 0.44% | — | #13 | $410.0万 | 35.4万股 | $0 | 0股 | +35.4万股 | 新买入 |
