| BVF INC/IL |
| 7.97% | 9.5% | #1 | $3.12亿 | 1,600.1万股 | $2.98亿 | 1,600.1万股 | 00.00% | 持仓不变 |
| 深轨资本Deep Track Capital, LP |
| 1.98% | 1.95% | #12 | $1.36亿 | 699.9万股 | $1.19亿 | 640.9万股 | +59.0万股+9.21% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.05% | — | #41 | $8,334.4万 | 428.1万股 | $0 | 0股 | +428.1万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.03% | 0.03% | #48 | $6,552.6万 | 336.6万股 | $4,456.2万 | 239.1万股 | +97.5万股+40.78% | 加仓 |
| Cormorant Asset Management, LP |
| 3.17% | 4.19% | #3 | $6,241.0万 | 320.5万股 | $8,351.5万 | 448.0万股 | -127.5万股-28.46% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #52 | $6,008.3万 | 308.6万股 | $0 | 0股 | +308.6万股 | 新买入 |
| Logos Global Management LP |
| 2.24% | 1.4% | #10 | $5,208.2万 | 267.5万股 | $2,796.0万 | 150.0万股 | +117.5万股+78.33% | 加仓 |
| 韦斯资产管理Weiss Asset Management LP |
| 0.53% | 0.54% | #17 | $5,026.8万 | 258.2万股 | $3,184.3万 | 170.8万股 | +87.3万股+51.13% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #80 | $4,785.3万 | 245.8万股 | $3,880.3万 | 208.2万股 | +37.6万股+18.07% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.02% | #54 | $3,339.8万 | 171.5万股 | $2,092.0万 | 112.2万股 | +59.3万股+52.84% | 加仓 |
| MPM BioImpact LLC |
| 1.91% | 2.61% | #13 | $3,128.8万 | 160.7万股 | $3,375.9万 | 181.1万股 | -20.4万股-11.27% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #100 | $2,760.4万 | 138.6万股 | $1,842.9万 | 108.9万股 | +29.8万股+27.37% | 加仓 |
| Vivo Capital, LLC |
| 2.49% | 1.55% | #6 | $2,725.8万 | 140.0万股 | $1,864.0万 | 100.0万股 | +40.0万股+40.00% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #96 | $2,277.0万 | 116.9万股 | $1,067.2万 | 57.3万股 | +59.7万股+104.27% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.02% | 0.03% | #51 | $2,256.1万 | 115.9万股 | $2,550.9万 | 136.9万股 | -21.0万股-15.33% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #128 | $2,131.6万 | 109.5万股 | $1,904.7万 | 102.2万股 | +7.3万股+7.14% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #94 | $2,027.9万 | 104.2万股 | $2,413.7万 | 129.5万股 | -25.3万股-19.56% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.03% | #56 | $1,777.1万 | 91.3万股 | $1,986.3万 | 106.6万股 | -15.3万股-14.35% | 减仓 |
| GREAT POINT PARTNERS LLC |
| 3.15% | 2.14% | #4 | $1,666.3万 | 85.6万股 | $932.0万 | 50.0万股 | +35.6万股+71.16% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.07% | 0.01% | #38 | $1,497.3万 | 77.0万股 | $177.1万 | 13.4万股 | +63.5万股+473.05% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #108 | $1,463.9万 | 75.2万股 | $1,351.0万 | 72.5万股 | +2.7万股+3.74% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | <0.01% | #76 | $1,461.8万 | 75.1万股 | $130.7万 | 7.0万股 | +68.1万股+970.40% | 加仓 |
| Trails Edge Capital Partners, LP |
| 2.32% | — | #9 | $1,460.3万 | 75.0万股 | $0 | 0股 | +75.0万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #106 | $1,401.7万 | 72.0万股 | $2,252.9万 | 120.9万股 | -48.9万股-40.43% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| 0.02% | 0.02% | #55 | $1,322.5万 | 67.9万股 | $908.8万 | 48.8万股 | +19.2万股+39.31% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.01% | #63 | $1,252.4万 | 64.3万股 | $515.9万 | 27.7万股 | +36.6万股+132.42% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $1,238.7万 | 63.6万股 | $1,073.8万 | 57.6万股 | +6.0万股+10.43% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #117 | $1,097.3万 | 56.4万股 | $184.0万 | 25.7万股 | +30.7万股+119.60% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | <0.01% | #73 | $1,071.5万 | 55.0万股 | $207.5万 | 11.1万股 | +43.9万股+394.34% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #72 | $966.2万 | 49.6万股 | $80.0万 | 4.3万股 | +45.3万股+1,056.28% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.04% | — | #45 | $887.4万 | 45.6万股 | $0 | 0股 | +45.6万股 | 新买入 |
| Algert全球ALGERT GLOBAL LLC |
| 0.09% | 0.04% | #32 | $753.4万 | 38.7万股 | $281.9万 | 15.1万股 | +23.6万股+155.83% | 加仓 |
| Rhenman & Partners Asset Management AB |
| 0.71% | 0.55% | #15 | $749.2万 | 38.5万股 | $446.4万 | 24.0万股 | +14.5万股+60.67% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.04% | 0.07% | #44 | $735.9万 | 37.8万股 | $923.3万 | 49.5万股 | -11.7万股-23.70% | 减仓 |
| Capricorn Fund Managers Ltd |
| 0.58% | — | #16 | $729.5万 | 37.5万股 | $0 | 0股 | +37.5万股 | 新买入 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $698.7万 | 35.9万股 | $86.1万 | 4.6万股 | +31.3万股+677.06% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #86 | $665.0万 | 34.2万股 | $447.1万 | 24.0万股 | +10.2万股+42.40% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| 0.05% | 0.08% | #42 | $654.7万 | 33.6万股 | $607.6万 | 32.6万股 | +1.0万股+3.15% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #112 | $639.6万 | 32.9万股 | $7.2万 | 3,879股 | +32.5万股+8,369.24% | 加仓 |
| J. Goldman & Co LP |
| 0.16% | 0.07% | #25 | $615.1万 | 31.6万股 | $255.2万 | 13.7万股 | +17.9万股+130.79% | 加仓 |
| Granahan 投资管理Granahan Investment Management, LLC |
| 0.22% | 0.2% | #20 | $611.1万 | 31.4万股 | $411.2万 | 22.1万股 | +9.3万股+42.29% | 加仓 |
| Boxer Capital Management, LLC |
| 0.4% | 0.67% | #19 | $535.4万 | 27.5万股 | $512.6万 | 27.5万股 | 00.00% | 持仓不变 |
| Walleye资本Walleye Capital LLC |
| 0.02% | 0.03% | #62 | $498.8万 | 25.6万股 | $704.0万 | 37.8万股 | -12.2万股-32.17% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.08% | 0.07% | #36 | $494.5万 | 25.4万股 | $473.4万 | 25.4万股 | 00.00% | 持仓不变 |
| Holocene顾问Holocene Advisors, LP |
| 0.01% | 0.03% | #69 | $486.8万 | 25.0万股 | $1,118.4万 | 60.0万股 | -35.0万股-58.33% | 减仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.18% | — | #22 | $486.8万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.08% | 0.04% | #34 | $420.3万 | 21.6万股 | $236.9万 | 12.7万股 | +8.9万股+69.84% | 加仓 |
| ACUTA CAPITAL PARTNERS, LLC |
| 2.93% | 2.52% | #5 | $419.9万 | 21.6万股 | $357.4万 | 19.2万股 | +2.4万股+12.46% | 加仓 |
| Verition基金管理Verition Fund Management LLC |
| 0.01% | — | #81 | $403.2万 | 20.7万股 | $0 | 0股 | +20.7万股 | 新买入 |
| HighVista Strategies LLC |
| 0.83% | 1% | #14 | $365.9万 | 18.8万股 | $361.5万 | 19.4万股 | -6,009股-3.10% | 减仓 |
