| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #90 | $1.15亿 | 1,050.9万股 | $7,835.3万 | 963.8万股 | +87.2万股+9.04% | 加仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 1.72% | 1.78% | #7 | $9,407.2万 | 857.5万股 | $6,971.8万 | 857.5万股 | 00.00% | 持仓不变 |
| BVF INC/IL |
| 2.37% | 2.19% | #5 | $9,265.0万 | 844.6万股 | $6,866.4万 | 844.6万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #89 | $5,846.1万 | 532.9万股 | $3,668.2万 | 451.2万股 | +81.7万股+18.11% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #117 | $4,296.0万 | 391.6万股 | $3,077.8万 | 378.6万股 | +13.0万股+3.45% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.49% | 0.54% | #15 | $4,034.8万 | 367.8万股 | $3,037.4万 | 373.6万股 | -5.8万股-1.55% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #50 | $3,430.0万 | 312.7万股 | $1,727.2万 | 212.4万股 | +100.2万股+47.18% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #80 | $2,484.9万 | 226.5万股 | $1,165.4万 | 143.3万股 | +83.2万股+58.02% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #104 | $2,446.8万 | 223.0万股 | $1,654.2万 | 203.4万股 | +19.6万股+9.62% | 加仓 |
| ALETHEA CAPITAL MANAGEMENT, LLC |
| 9.85% | 6.38% | #1 | $2,378.2万 | 216.8万股 | $1,243.4万 | 152.9万股 | +63.9万股+41.75% | 加仓 |
| Prosight Management, LP |
| 3.82% | 4.48% | #2 | $2,218.1万 | 202.2万股 | $2,729.0万 | 335.7万股 | -133.5万股-39.76% | 减仓 |
| 深轨资本Deep Track Capital, LP |
| 0.32% | 0.35% | #19 | $2,170.5万 | 197.9万股 | $2,149.2万 | 264.4万股 | -66.5万股-25.15% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | 0.02% | #40 | $1,825.2万 | 166.4万股 | $1,286.6万 | 158.3万股 | +8.1万股+5.13% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | — | #57 | $1,547.1万 | 141.0万股 | $0 | 0股 | +141.0万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #128 | $1,458.9万 | 133.0万股 | $1,000.6万 | 123.1万股 | +9.9万股+8.05% | 加仓 |
| NAN FUNG TRINITY (HK) Ltd |
| 1.27% | 0.95% | #9 | $1,288.8万 | 117.5万股 | $865.7万 | 106.5万股 | +11.0万股+10.33% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #51 | $1,283.4万 | 117.0万股 | $1,330.7万 | 163.7万股 | -46.7万股-28.52% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #78 | $1,282.6万 | 116.9万股 | $1,159.1万 | 142.6万股 | -25.7万股-18.01% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #123 | $1,273.5万 | 116.1万股 | $1,000.1万 | 123.0万股 | -6.9万股-5.63% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #126 | $1,272.9万 | 116.0万股 | $1,604.6万 | 181.3万股 | -65.3万股-36.00% | 减仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.02% | 0.01% | #42 | $1,092.7万 | 99.6万股 | $650.9万 | 80.1万股 | +19.6万股+24.42% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #102 | $1,058.2万 | 96.5万股 | $845.7万 | 104.0万股 | -7.6万股-7.27% | 减仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.04% | 0.02% | #34 | $1,041.0万 | 94.9万股 | $489.6万 | 60.2万股 | +34.7万股+57.58% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #111 | $911.8万 | 83.1万股 | $614.9万 | 75.6万股 | +7.5万股+9.90% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #75 | $780.3万 | 71.1万股 | $1,272.5万 | 156.5万股 | -85.4万股-54.55% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #114 | $742.0万 | 67.6万股 | $561.6万 | 69.1万股 | -1.4万股-2.09% | 减仓 |
| 跳跃金融Jump Financial, LLC |
| 0.06% | 0.05% | #29 | $740.5万 | 67.5万股 | $410.9万 | 50.5万股 | +17.0万股+33.55% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #96 | $690.6万 | 63.0万股 | $451.2万 | 55.5万股 | +7.5万股+13.44% | 加仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| <0.01% | <0.01% | #84 | $686.7万 | 62.6万股 | $549.0万 | 67.5万股 | -4.9万股-7.31% | 减仓 |
| Royce联营ROYCE & ASSOCIATES LP |
| 0.05% | — | #30 | $669.2万 | 61.0万股 | $0 | 0股 | +61.0万股 | 新买入 |
| Rhenman & Partners Asset Management AB |
| 0.61% | 0.27% | #13 | $648.9万 | 59.2万股 | $220.7万 | 27.2万股 | +32.0万股+117.86% | 加仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.18% | 0.09% | #24 | $624.0万 | 56.9万股 | $272.5万 | 33.5万股 | +23.4万股+69.70% | 加仓 |
| 木星资产管理JUPITER ASSET MANAGEMENT LTD |
| 0.03% | — | #39 | $559.3万 | 51.0万股 | $0 | 0股 | +51.0万股 | 新买入 |
| 1492 Capital Management LLC |
| 1.51% | 1.5% | #8 | $512.5万 | 46.7万股 | $395.2万 | 48.6万股 | -1.9万股-3.90% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #132 | $484.4万 | 44.2万股 | $404.2万 | 49.7万股 | -5.6万股-11.17% | 减仓 |
| SECTOR GAMMA AS |
| 1.03% | 0.79% | #10 | $475.0万 | 43.3万股 | $334.8万 | 41.2万股 | +2.1万股+5.15% | 加仓 |
| 英仕曼集团Man Group plc |
| 0.01% | 0.01% | #56 | $474.9万 | 43.3万股 | $386.2万 | 47.5万股 | -4.2万股-8.87% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #171 | $398.6万 | 36.3万股 | $258.3万 | 31.8万股 | +4.6万股+14.38% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #157 | $393.9万 | 35.9万股 | $248.3万 | 30.5万股 | +5.4万股+17.58% | 加仓 |
| IEQ资本IEQ CAPITAL, LLC |
| 0.02% | 0.01% | #45 | $381.9万 | 34.8万股 | $229.2万 | 28.2万股 | +6.6万股+23.49% | 加仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.06% | 0.04% | #28 | $377.2万 | 34.4万股 | $279.6万 | 34.4万股 | 00.00% | 持仓不变 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.42% | 0.38% | #17 | $323.7万 | 29.5万股 | $240.3万 | 29.6万股 | -483股-0.16% | 减仓 |
| OP资产管理OP Asset Management Ltd |
| 0.03% | — | #35 | $320.2万 | 29.2万股 | $0 | 0股 | +29.2万股 | 新买入 |
| Ally Bridge Group (NY) LLC |
| 2.81% | — | #3 | $318.1万 | 29.0万股 | $0 | 0股 | +29.0万股 | 新买入 |
| Ishara Investments LP |
| 2.19% | — | #6 | $303.6万 | 27.7万股 | $0 | 0股 | +27.7万股 | 新买入 |
| 保德信金融PRUDENTIAL FINANCIAL INC |
| <0.01% | <0.01% | #71 | $293.9万 | 26.8万股 | $33.6万 | 4.1万股 | +22.7万股+549.10% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| <0.01% | <0.01% | #67 | $293.7万 | 26.8万股 | $276.2万 | 34.0万股 | -7.2万股-21.18% | 减仓 |
| 五大湖顾问GREAT LAKES ADVISORS, LLC |
| 0.02% | 0.02% | #41 | $285.1万 | 26.0万股 | $276.1万 | 34.0万股 | -8.0万股-23.48% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #143 | $282.8万 | 25.8万股 | $206.8万 | 25.4万股 | +3,442股+1.35% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #176 | $269.8万 | 24.6万股 | $40.6万 | 5.3万股 | +19.3万股+367.78% | 加仓 |
