| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 3.89% | 4.36% | #5 | $7.76亿 | 1,991.9万股 | $7.59亿 | 1,991.9万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #97 | $1.61亿 | 413.5万股 | $1.50亿 | 393.5万股 | +20.0万股+5.08% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #56 | $1.27亿 | 324.9万股 | $7,774.1万 | 203.9万股 | +120.9万股+59.30% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #91 | $9,426.0万 | 241.9万股 | $8,580.5万 | 225.1万股 | +16.8万股+7.49% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #62 | $9,023.2万 | 231.6万股 | $6,629.1万 | 173.9万股 | +57.7万股+33.18% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #110 | $7,030.8万 | 180.5万股 | $6,545.5万 | 171.7万股 | +8.8万股+5.10% | 加仓 |
| BRAIDWELL LP |
| 2.58% | 2.31% | #8 | $6,963.4万 | 178.7万股 | $6,932.8万 | 181.9万股 | -3.1万股-1.72% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #45 | $5,950.7万 | 152.6万股 | $0 | 0股 | +152.6万股 | 新买入 |
| RTW投资RTW INVESTMENTS, LP |
| 0.49% | 0.56% | #18 | $5,797.0万 | 148.8万股 | $5,672.0万 | 148.8万股 | 00.00% | 持仓不变 |
| Boxer Capital Management, LLC |
| 4.34% | 6.81% | #4 | $5,756.7万 | 147.8万股 | $5,188.1万 | 136.1万股 | +11.7万股+8.57% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.04% | 0.02% | #40 | $5,754.5万 | 147.7万股 | $3,190.5万 | 83.7万股 | +64.0万股+76.48% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 1.35% | 1.58% | #12 | $5,631.8万 | 144.6万股 | $5,510.4万 | 144.6万股 | 00.00% | 持仓不变 |
| Ikarian Capital, LLC |
| 5.28% | 4.23% | #2 | $4,976.9万 | 127.7万股 | $5,206.4万 | 136.6万股 | -8.8万股-6.47% | 减仓 |
| ICONIQ 资本ICONIQ Capital, LLC |
| 1.42% | 1.08% | #11 | $4,934.5万 | 126.7万股 | $4,828.1万 | 126.7万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #99 | $4,142.1万 | 106.3万股 | $3,814.3万 | 100.0万股 | +6.3万股+6.25% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.06% | 0.04% | #38 | $3,771.5万 | 96.8万股 | $2,631.5万 | 69.0万股 | +27.8万股+40.23% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | <0.01% | #69 | $3,091.9万 | 79.4万股 | $1,663.3万 | 43.6万股 | +35.7万股+81.88% | 加仓 |
| Board of Trustees of The Leland Stanford Junior University |
| 5.06% | 3.11% | #3 | $2,695.1万 | 69.2万股 | $2,637.0万 | 69.2万股 | 00.00% | 持仓不变 |
| DIADEMA PARTNERS LP |
| 2.7% | 2.85% | #7 | $2,188.4万 | 56.2万股 | $1,677.5万 | 44.0万股 | +12.2万股+27.64% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.21% | 3.86% | #9 | $2,128.2万 | 54.6万股 | $3,781.2万 | 99.2万股 | -44.6万股-44.93% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #125 | $2,075.9万 | 53.3万股 | $1,391.6万 | 36.5万股 | +16.8万股+45.96% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.03% | #43 | $1,948.0万 | 50.0万股 | $2,191.9万 | 57.5万股 | -7.5万股-13.04% | 减仓 |
| Squadron Capital Management LLC |
| 6.05% | 5.31% | #1 | $1,948.0万 | 50.0万股 | $1,448.6万 | 38.0万股 | +12.0万股+31.58% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #55 | $1,842.8万 | 47.3万股 | $379.2万 | 9.9万股 | +37.4万股+375.53% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #127 | $1,694.9万 | 43.5万股 | $1,060.1万 | 64.8万股 | -21.3万股-32.82% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #123 | $1,494.9万 | 38.4万股 | $1,145.0万 | 30.0万股 | +8.3万股+27.75% | 加仓 |
| BOONE CAPITAL MANAGEMENT LLC |
| 3.44% | 3.29% | #6 | $1,472.7万 | 37.8万股 | $1,072.4万 | 28.1万股 | +9.7万股+34.36% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #106 | $1,429.2万 | 36.7万股 | $1,491.8万 | 39.1万股 | -2.5万股-6.27% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #107 | $1,428.8万 | 36.7万股 | $3,973.6万 | 104.2万股 | -67.6万股-64.82% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #103 | $1,395.0万 | 35.8万股 | $1,333.4万 | 35.0万股 | +8,253股+2.36% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #122 | $1,297.8万 | 33.3万股 | $925.7万 | 24.3万股 | +9.0万股+37.18% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.17% | 0.18% | #25 | $1,279.2万 | 32.8万股 | $1,358.1万 | 35.6万股 | -2.8万股-7.84% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #100 | $1,217.4万 | 31.3万股 | $1,200.8万 | 31.5万股 | -2,805股-0.89% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #95 | $1,137.5万 | 29.2万股 | $984.0万 | 25.8万股 | +3.4万股+13.11% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #146 | $1,079.1万 | 27.7万股 | $701.1万 | 18.4万股 | +9.3万股+50.60% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | 0.01% | #78 | $823.2万 | 21.1万股 | $876.6万 | 23.0万股 | -1.9万股-8.11% | 减仓 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #67 | $756.3万 | 19.4万股 | $618.7万 | 16.2万股 | +3.2万股+19.61% | 加仓 |
| PFM Health Sciences, LP |
| 0.65% | 0.4% | #16 | $753.2万 | 19.3万股 | $437.3万 | 11.5万股 | +7.9万股+68.51% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #124 | $740.7万 | 19.0万股 | $583.9万 | 15.3万股 | +3.7万股+24.12% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.02% | #58 | $737.1万 | 18.9万股 | $1,121.9万 | 29.4万股 | -10.5万股-35.71% | 减仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.09% | 0.08% | #35 | $726.5万 | 18.6万股 | $563.9万 | 14.8万股 | +3.9万股+26.06% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #109 | $680.7万 | 17.5万股 | $363.3万 | 9.5万股 | +7.9万股+83.36% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.01% | <0.01% | #68 | $588.7万 | 15.1万股 | $270.9万 | 7.1万股 | +8.0万股+112.65% | 加仓 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| 0.03% | — | #41 | $584.4万 | 15.0万股 | $0 | 0股 | +15.0万股 | 新买入 |
| Bruce & Co., Inc. |
| 1.58% | 1.58% | #10 | $564.9万 | 14.5万股 | $552.7万 | 14.5万股 | 00.00% | 持仓不变 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.01% | 0.01% | #61 | $561.3万 | 14.4万股 | $801.3万 | 21.0万股 | -6.6万股-31.47% | 减仓 |
| 保德信金融PRUDENTIAL FINANCIAL INC |
| 0.01% | <0.01% | #71 | $469.4万 | 12.0万股 | $305.8万 | 8.0万股 | +4.0万股+50.22% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.02% | <0.01% | #48 | $448.4万 | 11.5万股 | $43.8万 | 1.2万股 | +10.4万股+900.87% | 加仓 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #83 | $444.5万 | 11.4万股 | $459.8万 | 12.1万股 | -6,540股-5.42% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #133 | $436.1万 | 11.2万股 | $424.4万 | 11.1万股 | +594股+0.53% | 加仓 |
