| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #82 | $1.92亿 | 587.7万股 | $1.75亿 | 538.6万股 | +49.2万股+9.13% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 1.57% | 1.82% | #7 | $1.84亿 | 562.4万股 | $1.83亿 | 562.4万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| 0.01% | 0.01% | #61 | $1.74亿 | 531.3万股 | $1.75亿 | 538.4万股 | -7.1万股-1.31% | 减仓 |
| Lynx1 Capital Management LP |
| 26.03% | 24.51% | #1 | $1.32亿 | 403.8万股 | $1.55亿 | 476.4万股 | -72.5万股-15.22% | 减仓 |
| Redmile Group, LLC |
| 8.67% | 8.98% | #2 | $1.29亿 | 394.6万股 | $1.36亿 | 416.4万股 | -21.8万股-5.24% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.02% | #44 | $1.15亿 | 351.9万股 | $1.01亿 | 309.6万股 | +42.4万股+13.68% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | 0.01% | #63 | $1.13亿 | 345.3万股 | $8,312.1万 | 353.7万股 | -8.4万股-2.38% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.55% | 0.62% | #14 | $1.09亿 | 333.7万股 | $1.09亿 | 333.7万股 | 00.00% | 持仓不变 |
| 多伦多道明银行TORONTO DOMINION BANK |
| 0.12% | 0.15% | #25 | $1.04亿 | 317.3万股 | $1.03亿 | 317.3万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #83 | $9,332.5万 | 285.2万股 | $7,412.3万 | 227.7万股 | +57.6万股+25.29% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #59 | $8,709.2万 | 266.2万股 | $6,297.7万 | 193.4万股 | +72.8万股+37.62% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $8,464.5万 | 258.7万股 | $7,669.8万 | 235.6万股 | +23.1万股+9.82% | 加仓 |
| BVF INC/IL |
| 2.13% | 2.64% | #4 | $8,335.6万 | 254.8万股 | $8,294.8万 | 254.8万股 | 00.00% | 持仓不变 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.05% | 0.01% | #31 | $7,902.3万 | 241.5万股 | $817.0万 | 25.1万股 | +216.4万股+862.54% | 加仓 |
| Siren, L.L.C. |
| 1.32% | 1.8% | #9 | $6,528.8万 | 199.5万股 | $6,496.8万 | 199.5万股 | 00.00% | 持仓不变 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.62% | 0.7% | #13 | $5,966.5万 | 182.4万股 | $5,937.3万 | 182.4万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #41 | $5,935.8万 | 181.4万股 | $0 | 0股 | +181.4万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #84 | $4,988.4万 | 152.4万股 | $4,306.1万 | 132.2万股 | +20.2万股+15.28% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.05% | 0.04% | #32 | $3,692.1万 | 112.8万股 | $2,953.2万 | 90.7万股 | +22.1万股+24.41% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #62 | $3,317.4万 | 101.4万股 | $3,222.9万 | 99.0万股 | +2.4万股+2.42% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.06% | 0.13% | #29 | $2,727.9万 | 83.4万股 | $3,687.5万 | 113.3万股 | -29.9万股-26.38% | 减仓 |
| EcoR1 Capital, LLC |
| 1.17% | 0.14% | #11 | $2,404.9万 | 73.5万股 | $325.6万 | 10.0万股 | +63.5万股+635.00% | 加仓 |
| MPM BioImpact LLC |
| 1.44% | 1.93% | #8 | $2,366.7万 | 72.3万股 | $2,497.5万 | 76.7万股 | -4.4万股-5.70% | 减仓 |
| Opaleye Management Inc. |
| 2.07% | 3% | #5 | $2,290.4万 | 70.0万股 | $2,279.2万 | 70.0万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $1,882.5万 | 57.5万股 | $2,704.8万 | 83.1万股 | -25.5万股-30.74% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #126 | $1,855.2万 | 56.7万股 | $1,506.5万 | 46.3万股 | +10.4万股+22.54% | 加仓 |
| 百利吉福德BAILLIE GIFFORD & CO |
| 0.02% | 0.02% | #51 | $1,692.5万 | 51.7万股 | $1,872.8万 | 57.5万股 | -5.8万股-10.07% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #93 | $1,636.4万 | 50.0万股 | $1,405.4万 | 43.2万股 | +6.8万股+15.87% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #96 | $1,633.7万 | 49.9万股 | $584.2万 | 17.9万股 | +32.0万股+178.28% | 加仓 |
| Troluce Capital Advisors LLC |
| 1.67% | 1.3% | #6 | $1,624.3万 | 49.6万股 | $2,125.5万 | 65.3万股 | -15.6万股-23.96% | 减仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | <0.01% | #58 | $1,606.3万 | 49.1万股 | $532.2万 | 16.3万股 | +32.7万股+200.33% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.07% | 0.07% | #28 | $1,569.5万 | 48.0万股 | $1,417.9万 | 44.7万股 | +3.3万股+7.49% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #89 | $1,528.1万 | 46.7万股 | $1,423.4万 | 43.7万股 | +3.0万股+6.82% | 加仓 |
| Granahan 投资管理Granahan Investment Management, LLC |
| 0.54% | 0.53% | #15 | $1,510.4万 | 46.2万股 | $1,092.7万 | 33.6万股 | +12.6万股+37.55% | 加仓 |
| 奥地利Erste资产管理Erste Asset Management GmbH |
| 0.11% | 0.13% | #26 | $1,387.5万 | 42.8万股 | $1,416.9万 | 44.6万股 | -1.8万股-3.95% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #79 | $1,317.0万 | 40.3万股 | $1,162.2万 | 35.7万股 | +4.6万股+12.76% | 加仓 |
| Parkman Healthcare Partners LLC |
| 1.19% | 1.13% | #10 | $1,163.0万 | 35.5万股 | $1,095.7万 | 33.7万股 | +1.9万股+5.62% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.02% | 0.02% | #47 | $1,162.1万 | 35.5万股 | $1,027.2万 | 31.5万股 | +4.0万股+12.57% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #121 | $1,085.3万 | 33.2万股 | $281.5万 | 8.6万股 | +24.5万股+283.70% | 加仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 0.45% | 0.83% | #17 | $981.6万 | 30.0万股 | $1,628.0万 | 50.0万股 | -20.0万股-40.00% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #81 | $854.1万 | 26.1万股 | $1,667.5万 | 51.2万股 | -25.1万股-49.03% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #138 | $849.8万 | 26.0万股 | $1,768.3万 | 54.3万股 | -28.3万股-52.18% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #143 | $848.1万 | 25.9万股 | $843.4万 | 26.5万股 | -6,121股-2.31% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #123 | $677.7万 | 20.7万股 | $515.4万 | 15.8万股 | +4.9万股+30.83% | 加仓 |
| Birchview Capital, LP |
| 2.63% | 3.89% | #3 | $582.8万 | 17.8万股 | $683.8万 | 21.0万股 | -3.2万股-15.19% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #122 | $537.5万 | 16.4万股 | $466.9万 | 14.3万股 | +2.1万股+14.55% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | — | #139 | $534.0万 | 16.3万股 | $0 | 0股 | +16.3万股 | 新买入 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #116 | $479.0万 | 14.6万股 | $464.9万 | 14.3万股 | +3,602股+2.52% | 加仓 |
| DAFNA Capital Management LLC |
| 0.82% | 0.97% | #12 | $428.2万 | 13.1万股 | $426.1万 | 13.1万股 | 00.00% | 持仓不变 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.03% | — | #40 | $424.2万 | 13.0万股 | $0 | 0股 | +13.0万股 | 新买入 |
