| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.03% | #42 | $1.82亿 | 572.2万股 | $1.42亿 | 470.6万股 | +101.6万股+21.58% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 1.32% | 1.46% | #9 | $1.55亿 | 487.0万股 | $1.47亿 | 487.0万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| 0.01% | 0.01% | #70 | $1.37亿 | 430.7万股 | $1.46亿 | 482.9万股 | -52.2万股-10.81% | 减仓 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| 0.07% | 0.09% | #31 | $1.16亿 | 363.8万股 | $1.11亿 | 369.3万股 | -5.5万股-1.49% | 减仓 |
| Bellevue 集团Bellevue Group AG |
| 1.86% | 2.01% | #6 | $8,852.7万 | 278.8万股 | $8,432.4万 | 279.7万股 | -8,558股-0.31% | 减仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 3.82% | 4.06% | #2 | $8,411.7万 | 264.9万股 | $7,987.8万 | 264.9万股 | 00.00% | 持仓不变 |
| Vestal Point 资本Vestal Point Capital, LP |
| 1.34% | 2.33% | #8 | $5,715.0万 | 180.0万股 | $8,342.1万 | 276.7万股 | -96.7万股-34.94% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.04% | 0.02% | #39 | $5,235.5万 | 164.9万股 | $3,079.1万 | 102.1万股 | +62.8万股+61.46% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.02% | 0.02% | #50 | $5,070.6万 | 159.7万股 | $3,730.8万 | 123.7万股 | +36.0万股+29.06% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.55% | 0.64% | #17 | $4,533.9万 | 142.8万股 | $3,581.8万 | 118.8万股 | +24.0万股+20.20% | 加仓 |
| Caligan Partners LP |
| 2.06% | — | #5 | $4,385.7万 | 138.1万股 | $0 | 0股 | +138.1万股 | 新买入 |
| Kynam Capital Management, LP |
| 2.41% | 1.65% | #4 | $4,365.6万 | 137.5万股 | $2,668.1万 | 88.5万股 | +49.0万股+55.38% | 加仓 |
| BVF INC/IL |
| 1.05% | 1.24% | #10 | $4,109.9万 | 129.4万股 | $3,902.8万 | 129.4万股 | 00.00% | 持仓不变 |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.05% | 0.02% | #36 | $3,841.4万 | 121.0万股 | $1,509.1万 | 50.1万股 | +70.9万股+141.45% | 加仓 |
| Trails Edge Capital Partners, LP |
| 5.36% | 4.71% | #1 | $3,375.8万 | 106.3万股 | $2,058.0万 | 68.3万股 | +38.1万股+55.76% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #98 | $3,189.6万 | 100.5万股 | $1,978.8万 | 65.6万股 | +34.8万股+53.07% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.03% | 0.04% | #40 | $3,144.1万 | 99.0万股 | $3,323.3万 | 110.2万股 | -11.2万股-10.16% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #79 | $2,638.6万 | 83.1万股 | $2,771.8万 | 91.9万股 | -8.8万股-9.60% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #58 | $2,250.4万 | 70.9万股 | $0 | 0股 | +70.9万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #80 | $2,070.0万 | 65.2万股 | $724.5万 | 24.0万股 | +41.2万股+171.31% | 加仓 |
| Logos Global Management LP |
| 0.82% | 2.26% | #13 | $1,905.0万 | 60.0万股 | $4,522.5万 | 150.0万股 | -90.0万股-60.00% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.01% | #54 | $1,876.2万 | 59.1万股 | $543.7万 | 18.0万股 | +41.1万股+227.68% | 加仓 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| 0.05% | 0.07% | #34 | $1,873.3万 | 59.0万股 | $1,909.0万 | 63.3万股 | -4.3万股-6.82% | 减仓 |
| BRAIDWELL LP |
| 0.61% | — | #16 | $1,655.2万 | 52.1万股 | $0 | 0股 | +52.1万股 | 新买入 |
| Jones Hill Capital LP |
| 3.46% | — | #3 | $1,628.3万 | 51.3万股 | $0 | 0股 | +51.3万股 | 新买入 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | 0.01% | #61 | $1,542.4万 | 48.6万股 | $1,565.2万 | 51.9万股 | -3.3万股-6.42% | 减仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.34% | 0.38% | #18 | $1,539.2万 | 48.5万股 | $1,461.6万 | 48.5万股 | 00.00% | 持仓不变 |
| Fulcrum Asset Management LLP |
| 1.43% | — | #7 | $1,429.8万 | 47.0万股 | $0 | 0股 | +47.0万股 | 新买入 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| <0.01% | <0.01% | #73 | $1,292.9万 | 40.7万股 | $1,228.2万 | 40.7万股 | -154股-0.04% | 减仓 |
| Caption管理Caption Management, LLC |
| 0.06% | 0.34% | #32 | $1,287.8万 | 40.6万股 | $5,831.9万 | 193.4万股 | -152.9万股-79.03% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #68 | $1,286.2万 | 40.5万股 | $1,010.6万 | 33.5万股 | +7.0万股+20.86% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.05% | 0.05% | #33 | $1,183.3万 | 37.3万股 | $936.3万 | 27.0万股 | +10.3万股+38.30% | 加仓 |
| 康托·菲茨杰拉德CANTOR FITZGERALD, L. P. |
| 0.12% | 0.13% | #28 | $1,079.8万 | 34.0万股 | $906.6万 | 30.1万股 | +3.9万股+13.10% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | 0.04% | #43 | $1,005.7万 | 31.7万股 | $955.0万 | 31.7万股 | 00.00% | 持仓不变 |
| 深轨资本Deep Track Capital, LP |
| 0.14% | 0.95% | #25 | $988.1万 | 31.1万股 | $5,824.6万 | 193.2万股 | -162.1万股-83.89% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #93 | $963.4万 | 30.3万股 | $1,797.7万 | 59.6万股 | -29.3万股-49.11% | 减仓 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | <0.01% | #83 | $951.2万 | 30.0万股 | $470.5万 | 15.6万股 | +14.4万股+91.92% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.13% | — | #27 | $938.4万 | 29.6万股 | $0 | 0股 | +29.6万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #95 | $904.5万 | 28.5万股 | $102.9万 | 3.4万股 | +25.1万股+734.86% | 加仓 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.13% | 0.12% | #26 | $872.1万 | 27.5万股 | $594.9万 | 19.7万股 | +7.7万股+39.21% | 加仓 |
| DIADEMA PARTNERS LP |
| 1% | 0.99% | #11 | $809.2万 | 25.5万股 | $582.5万 | 19.3万股 | +6.2万股+31.92% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | — | #65 | $708.4万 | 22.3万股 | $0 | 0股 | +22.3万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #104 | $596.4万 | 18.8万股 | $978.0万 | 26.9万股 | -8.1万股-30.22% | 减仓 |
| Catalio Capital Management, LP |
| 0.88% | 0.53% | #12 | $470.0万 | 14.8万股 | $254.3万 | 8.4万股 | +6.4万股+75.51% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $436.0万 | 13.7万股 | $360.3万 | 11.9万股 | +1.8万股+14.92% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #84 | $426.0万 | 13.4万股 | $0 | 0股 | +13.4万股 | 新买入 |
| 跳跃金融Jump Financial, LLC |
| 0.03% | 0.02% | #41 | $418.9万 | 13.2万股 | $116.1万 | 3.8万股 | +9.3万股+242.74% | 加仓 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.08% | 0.02% | #29 | $402.1万 | 12.7万股 | $105.3万 | 3.5万股 | +9.2万股+262.62% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #107 | $368.8万 | 11.6万股 | $623.7万 | 20.7万股 | -9.1万股-43.86% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.05% | 0.05% | #35 | $368.7万 | 11.6万股 | $289.8万 | 9.6万股 | +2.0万股+20.84% | 加仓 |
