| Avoro资本顾问Avoro Capital Advisors LLC |
| 1.46% | 0.95% | #10 | $1.63亿 | 2,388.9万股 | $9,699.9万 | 2,170.0万股 | +218.9万股+10.09% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.39% | 1.12% | #12 | $1.60亿 | 2,355.6万股 | $1.05亿 | 2,355.6万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #58 | $1.55亿 | 2,271.3万股 | $9,999.2万 | 2,237.0万股 | +34.3万股+1.54% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #92 | $1.41亿 | 2,069.2万股 | $8,209.4万 | 1,836.6万股 | +232.6万股+12.67% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 3.09% | 2.25% | #3 | $1.32亿 | 1,941.5万股 | $8,046.0万 | 1,800.0万股 | +141.5万股+7.86% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #68 | $1.12亿 | 1,648.7万股 | $6,313.6万 | 1,930.8万股 | -282.0万股-14.61% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.79% | 0.61% | #18 | $9,234.5万 | 1,356.0万股 | $6,115.1万 | 1,368.0万股 | -12.0万股-0.88% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #75 | $9,082.1万 | 1,333.6万股 | $6,401.6万 | 1,432.1万股 | -98.5万股-6.88% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #95 | $8,497.9万 | 1,247.9万股 | $4,573.5万 | 1,023.2万股 | +224.7万股+21.96% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #88 | $7,778.3万 | 1,142.2万股 | $5,010.5万 | 1,120.9万股 | +21.3万股+1.90% | 加仓 |
| Siren, L.L.C. |
| 1.36% | 1.09% | #14 | $6,705.5万 | 984.7万股 | $3,947.0万 | 883.0万股 | +101.7万股+11.51% | 加仓 |
| Octagon Capital Advisors LP |
| 5.93% | 4.38% | #1 | $6,601.1万 | 969.3万股 | $3,960.4万 | 886.0万股 | +83.3万股+9.41% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #87 | $4,468.5万 | 656.0万股 | $2,473.2万 | 553.2万股 | +102.8万股+18.59% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.08% | 0.09% | #37 | $3,484.8万 | 511.7万股 | $2,527.5万 | 565.4万股 | -53.7万股-9.50% | 减仓 |
| MPM BioImpact LLC |
| 1.87% | — | #8 | $3,064.5万 | 450.0万股 | $0 | 0股 | +450.0万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #57 | $2,995.5万 | 439.9万股 | $1,979.0万 | 442.7万股 | -2.9万股-0.65% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.14% | 0.1% | #33 | $2,727.2万 | 400.5万股 | $1,790.1万 | 400.5万股 | 00.00% | 持仓不变 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #71 | $2,707.4万 | 397.6万股 | $280.0万 | 62.6万股 | +334.9万股+534.71% | 加仓 |
| 安大略医疗养老基金(HOOPP)HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.04% | 0.02% | #41 | $2,646.0万 | 388.6万股 | $1,288.8万 | 288.3万股 | +100.2万股+34.76% | 加仓 |
| Casdin Capital, LLC |
| 1.11% | 1.1% | #15 | $2,213.3万 | 325.0万股 | $1,452.8万 | 325.0万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #117 | $2,138.3万 | 314.0万股 | $904.1万 | 202.2万股 | +111.8万股+55.25% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.95% | 0.78% | #16 | $2,070.6万 | 304.0万股 | $1,331.8万 | 297.9万股 | +6.1万股+2.05% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.02% | <0.01% | #51 | $1,886.8万 | 277.1万股 | $8.6万 | 1.9万股 | +275.1万股+14,242.59% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.02% | 0.01% | #49 | $1,584.8万 | 232.7万股 | $456.4万 | 102.1万股 | +130.6万股+127.91% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.07% | — | #38 | $1,532.3万 | 225.0万股 | $0 | 0股 | +225.0万股 | 新买入 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | — | #101 | $1,521.1万 | 223.4万股 | $0 | 0股 | +223.4万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #96 | $1,516.0万 | 222.6万股 | $811.0万 | 181.4万股 | +41.2万股+22.70% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #93 | $1,498.7万 | 220.1万股 | $808.4万 | 180.9万股 | +39.2万股+21.68% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #70 | $1,448.4万 | 212.7万股 | $1,467.0万 | 328.2万股 | -115.5万股-35.19% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.26% | — | #27 | $1,362.0万 | 200.0万股 | $0 | 0股 | +200.0万股 | 新买入 |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 0.66% | 0.48% | #19 | $1,356.7万 | 199.2万股 | $869.3万 | 194.5万股 | +4.8万股+2.45% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #82 | $1,291.5万 | 189.6万股 | $684.1万 | 153.0万股 | +36.6万股+23.92% | 加仓 |
| B Group, Inc. |
| 5.76% | 5.97% | #2 | $1,226.2万 | 180.1万股 | $804.8万 | 180.1万股 | 00.00% | 持仓不变 |
| Affinity Asset Advisors, LLC |
| 0.54% | 0.23% | #20 | $1,191.8万 | 175.0万股 | $447.0万 | 100.0万股 | +75.0万股+75.00% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #105 | $1,166.7万 | 171.3万股 | $226.6万 | 50.7万股 | +120.6万股+238.02% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #90 | $1,110.5万 | 163.1万股 | $1,144.5万 | 281.2万股 | -118.1万股-42.01% | 减仓 |
| HEIGHTS CAPITAL MANAGEMENT, INC |
| 2.36% | — | #5 | $1,021.5万 | 150.0万股 | $0 | 0股 | +150.0万股 | 新买入 |
| Seven Fleet Capital Management LP |
| 1.64% | 0.89% | #9 | $994.0万 | 150.4万股 | $279.7万 | 62.6万股 | +87.9万股+140.43% | 加仓 |
| Palo Alto Investors LP |
| 1.38% | 0.95% | #13 | $947.5万 | 139.1万股 | $621.9万 | 139.1万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #134 | $934.9万 | 137.3万股 | $749.6万 | 167.7万股 | -30.4万股-18.14% | 减仓 |
| Granahan 投资管理Granahan Investment Management, LLC |
| 0.32% | 0.19% | #24 | $888.8万 | 130.5万股 | $394.8万 | 88.3万股 | +42.2万股+47.77% | 加仓 |
| Quantum Private Wealth, LLC |
| 1.42% | 1.17% | #11 | $553.0万 | 81.2万股 | $379.6万 | 84.9万股 | -3.7万股-4.38% | 减仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| <0.01% | — | #80 | $538.8万 | 79.1万股 | $0 | 0股 | +79.1万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #156 | $515.7万 | 76.6万股 | $307.2万 | 75.5万股 | +1.2万股+1.52% | 加仓 |
| GordonMD Global Investments LP |
| 2% | 15.47% | #7 | $506.2万 | 72.3万股 | $2,221.5万 | 73.8万股 | -1.4万股-1.95% | 减仓 |
| Sands Capital Alternatives, LLC |
| 0.8% | 0.77% | #17 | $493.6万 | 72.5万股 | $324.0万 | 72.5万股 | 00.00% | 持仓不变 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #124 | $475.3万 | 69.8万股 | $271.8万 | 60.8万股 | +9.0万股+14.77% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #149 | $464.8万 | 68.3万股 | $109.6万 | 24.5万股 | +43.7万股+178.49% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #91 | $435.9万 | 64.0万股 | $53.7万 | 12.0万股 | +52.0万股+432.48% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #59 | $402.1万 | 59.0万股 | $81.4万 | 18.2万股 | +40.8万股+224.10% | 加仓 |
