| NEA Management Company, LLC |
| 15.53% | 8.97% | #1 | $2.47亿 | 1,322.2万股 | $1.58亿 | 1,322.2万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| 0.01% | 0.01% | #86 | $2.34亿 | 1,256.3万股 | $9,589.4万 | 803.8万股 | +452.5万股+56.29% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #109 | $2.08亿 | 1,115.5万股 | $1.22亿 | 1,024.0万股 | +91.5万股+8.93% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 4.04% | 3.05% | #9 | $1.85亿 | 993.9万股 | $1.19亿 | 994.0万股 | -100股-0.00% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.01% | #77 | $1.06亿 | 568.5万股 | $6,190.6万 | 518.9万股 | +49.6万股+9.55% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #118 | $1.03亿 | 553.1万股 | $5,939.4万 | 497.9万股 | +55.2万股+11.09% | 加仓 |
| Vivo Capital, LLC |
| 8.68% | 5.05% | #4 | $9,501.6万 | 509.5万股 | $6,077.9万 | 509.5万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.24% | 0.05% | #40 | $7,611.7万 | 408.1万股 | $1,193.9万 | 100.1万股 | +308.1万股+307.81% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 1.35% | 0.72% | #16 | $5,781.5万 | 310.0万股 | $2,584.6万 | 216.7万股 | +93.3万股+43.09% | 加仓 |
| MPM BioImpact LLC |
| 3.5% | 3.04% | #10 | $5,732.2万 | 307.4万股 | $3,935.0万 | 329.8万股 | -22.5万股-6.82% | 减仓 |
| Frontier资本管理FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.53% | 0.24% | #26 | $5,726.9万 | 307.1万股 | $2,379.2万 | 199.4万股 | +107.6万股+53.98% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #130 | $5,645.9万 | 302.7万股 | $3,179.7万 | 266.5万股 | +36.2万股+13.58% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #110 | $5,462.0万 | 292.8万股 | $3,315.0万 | 277.8万股 | +15.0万股+5.39% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.04% | 0.05% | #64 | $4,987.3万 | 267.4万股 | $4,731.5万 | 396.6万股 | -129.2万股-32.57% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.66% | 0.52% | #24 | $4,960.9万 | 266.0万股 | $3,128.4万 | 262.2万股 | +3.8万股+1.44% | 加仓 |
| Rubric资本管理Rubric Capital Management LP |
| 0.43% | 0.47% | #32 | $4,670.9万 | 250.5万股 | $4,428.9万 | 371.2万股 | -120.8万股-32.54% | 减仓 |
| Artia Global Partners LP |
| 7.61% | 4.81% | #5 | $4,123.2万 | 221.1万股 | $2,402.2万 | 201.4万股 | +19.7万股+9.80% | 加仓 |
| ACORN CAPITAL ADVISORS, LLC |
| 10.92% | 7.27% | #2 | $4,000.1万 | 214.5万股 | $2,558.8万 | 214.5万股 | 00.00% | 持仓不变 |
| First Light Asset Management, LLC |
| 2.38% | — | #12 | $3,911.3万 | 209.7万股 | $0 | 0股 | +209.7万股 | 新买入 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.04% | 0.02% | #66 | $3,755.7万 | 201.4万股 | $2,035.3万 | 170.6万股 | +30.8万股+18.04% | 加仓 |
| Logos Global Management LP |
| 1.51% | 1.43% | #15 | $3,506.2万 | 188.0万股 | $2,863.2万 | 240.0万股 | -52.0万股-21.67% | 减仓 |
| Affinity Asset Advisors, LLC |
| 1.52% | 1.23% | #14 | $3,357.3万 | 180.0万股 | $2,386.2万 | 200.0万股 | -20.0万股-10.00% | 减仓 |
| EMERALD ADVISERS, LLC |
| 0.79% | 0.69% | #21 | $3,352.5万 | 179.8万股 | $2,194.6万 | 184.0万股 | -4.2万股-2.28% | 减仓 |
| Siren, L.L.C. |
| 0.67% | 0.59% | #23 | $3,332.5万 | 178.7万股 | $2,131.7万 | 178.7万股 | 00.00% | 持仓不变 |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 10.56% | 6.63% | #3 | $3,250.1万 | 174.3万股 | $1,853.6万 | 155.4万股 | +18.9万股+12.16% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| 0.01% | 0.01% | #89 | $3,038.9万 | 166.1万股 | $2,093.8万 | 178.8万股 | -12.7万股-7.12% | 减仓 |
| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 0.08% | 0.11% | #55 | $2,880.8万 | 154.5万股 | $3,816.0万 | 319.9万股 | -165.4万股-51.71% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #127 | $2,858.8万 | 153.3万股 | $1,451.8万 | 121.7万股 | +31.6万股+25.96% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.04% | — | #67 | $2,844.7万 | 152.5万股 | $0 | 0股 | +152.5万股 | 新买入 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #87 | $2,810.1万 | 235.5万股 | $3,562.5万 | 284.5万股 | -49.0万股-17.22% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.5% | 0.58% | #29 | $2,667.5万 | 143.0万股 | $2,928.1万 | 245.4万股 | -102.4万股-41.73% | 减仓 |
| Jones Hill Capital LP |
| 5.31% | 0.95% | #8 | $2,497.6万 | 133.9万股 | $441.6万 | 37.0万股 | +96.9万股+261.78% | 加仓 |
| NAN FUNG TRINITY (HK) Ltd |
| 2.23% | 1.5% | #13 | $2,263.4万 | 121.4万股 | $1,363.5万 | 114.3万股 | +7.1万股+6.18% | 加仓 |
| EMERALD MUTUAL FUND ADVISERS 信托EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.79% | 0.73% | #20 | $2,258.4万 | 121.1万股 | $1,506.2万 | 126.2万股 | -5.2万股-4.08% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #122 | $2,242.7万 | 120.3万股 | $1,464.7万 | 122.8万股 | -2.5万股-2.06% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #88 | $2,218.8万 | 119.1万股 | $0 | 0股 | +119.1万股 | 新买入 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.76% | 0.78% | #22 | $2,200.0万 | 118.0万股 | $1,932.7万 | 162.0万股 | -44.0万股-27.18% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #145 | $2,194.9万 | 117.7万股 | $1,155.5万 | 96.9万股 | +20.8万股+21.50% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #102 | $2,130.0万 | 114.2万股 | $63.9万 | 5.4万股 | +108.8万股+2,031.34% | 加仓 |
| Saturn V Capital Management LP |
| 2.81% | — | #11 | $1,962.1万 | 105.2万股 | $0 | 0股 | +105.2万股 | 新买入 |
| 普特南投资管理FLPUTNAM INVESTMENT MANAGEMENT CO |
| 0.23% | 0.19% | #41 | $1,936.0万 | 103.8万股 | $1,268.5万 | 106.3万股 | -2.5万股-2.37% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #119 | $1,876.3万 | 100.6万股 | $962.3万 | 80.7万股 | +19.9万股+24.72% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #132 | $1,857.4万 | 99.6万股 | $675.3万 | 56.6万股 | +43.0万股+75.94% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #116 | $1,800.5万 | 96.5万股 | $1,002.8万 | 84.1万股 | +12.5万股+14.85% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.08% | — | #56 | $1,800.3万 | 96.6万股 | $0 | 0股 | +96.6万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #76 | $1,576.1万 | 84.5万股 | $565.3万 | 47.4万股 | +37.1万股+78.35% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #105 | $1,568.6万 | 84.1万股 | $852.6万 | 71.5万股 | +12.6万股+17.69% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #151 | $1,492.9万 | 80.0万股 | $3,936.1万 | 430.2万股 | -350.1万股-81.39% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #106 | $1,427.1万 | 76.5万股 | $224.5万 | 18.8万股 | +57.7万股+306.61% | 加仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.49% | 0.31% | #30 | $1,352.1万 | 72.5万股 | $626.3万 | 52.5万股 | +20.0万股+38.10% | 加仓 |
