| 富达投资FMR LLC |
| 0.02% | 0.01% | #75 | $5.09亿 | 1,002.5万股 | $2.68亿 | 682.9万股 | +319.6万股+46.80% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 6.49% | 6.18% | #2 | $3.44亿 | 677.7万股 | $3.12亿 | 796.0万股 | -118.3万股-14.86% | 减仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.77% | 0.71% | #28 | $3.26亿 | 643.1万股 | $1.99亿 | 506.6万股 | +136.5万股+26.94% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #122 | $2.21亿 | 436.0万股 | $1.44亿 | 368.5万股 | +67.5万股+18.32% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 4.74% | 3.56% | #6 | $2.03亿 | 400.0万股 | $1.27亿 | 325.0万股 | +75.0万股+23.08% | 加仓 |
| Commodore Capital LP |
| 9.9% | 7.43% | #1 | $1.66亿 | 327.5万股 | $1.28亿 | 327.5万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #82 | $1.47亿 | 290.4万股 | $383.2万 | 9.8万股 | +280.6万股+2,870.84% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #127 | $1.30亿 | 256.9万股 | $0 | 0股 | +256.9万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #86 | $1.09亿 | 214.1万股 | $7,336.3万 | 187.2万股 | +26.9万股+14.40% | 加仓 |
| Fairmount Funds Management LLC |
| 6.22% | 5.25% | #3 | $9,417.4万 | 185.6万股 | $7,274.1万 | 185.6万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 1.82% | 0.81% | #16 | $9,005.1万 | 177.4万股 | $2,925.2万 | 74.6万股 | +102.8万股+137.78% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 1.59% | 2.17% | #19 | $7,561.8万 | 149.0万股 | $9,097.8万 | 232.1万股 | -83.1万股-35.80% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #118 | $7,143.1万 | 140.7万股 | $4,181.3万 | 106.6万股 | +34.1万股+31.96% | 加仓 |
| First Light Asset Management, LLC |
| 4.2% | 0.71% | #8 | $6,905.8万 | 136.1万股 | $791.3万 | 20.2万股 | +115.9万股+574.08% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #140 | $6,159.1万 | 121.4万股 | $4,277.1万 | 109.1万股 | +12.3万股+11.23% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.06% | 0.04% | #63 | $5,896.1万 | 116.2万股 | $3,643.8万 | 93.0万股 | +23.2万股+24.98% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.08% | — | #60 | $5,497.8万 | 108.3万股 | $0 | 0股 | +108.3万股 | 新买入 |
| Novo Holdings A/S |
| 2.96% | 4.07% | #12 | $5,075.0万 | 100.0万股 | $5,017.6万 | 128.0万股 | -28.0万股-21.88% | 减仓 |
| First Turn Management, LLC |
| 5.18% | 2.73% | #5 | $4,843.4万 | 95.4万股 | $2,445.4万 | 62.4万股 | +33.1万股+52.98% | 加仓 |
| 萨姆林资本SAMLYN CAPITAL, LLC |
| 0.75% | — | #29 | $4,631.6万 | 91.3万股 | $0 | 0股 | +91.3万股 | 新买入 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.23% | 0.2% | #45 | $4,593.8万 | 90.5万股 | $3,548.3万 | 90.5万股 | 00.00% | 持仓不变 |
| 康得利安资管Candriam S.C.A. |
| 0.21% | 0.03% | #47 | $4,591.9万 | 90.6万股 | $697.7万 | 45.3万股 | +45.3万股+99.92% | 加仓 |
| Tri Locum Partners LP |
| 5.41% | — | #4 | $4,398.6万 | 86.7万股 | $0 | 0股 | +86.7万股 | 新买入 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | <0.01% | #87 | $3,513.0万 | 89.6万股 | $1,188.7万 | 77.2万股 | +12.4万股+16.10% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #107 | $3,407.5万 | 67.1万股 | $2,671.4万 | 68.2万股 | -1.0万股-1.51% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.02% | #70 | $3,081.5万 | 60.7万股 | $1,215.3万 | 31.0万股 | +29.7万股+95.85% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #85 | $3,061.7万 | 60.4万股 | $0 | 0股 | +60.4万股 | 新买入 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.01% | <0.01% | #84 | $2,873.3万 | 56.6万股 | $243.5万 | 6.2万股 | +50.4万股+811.46% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #146 | $2,856.0万 | 56.3万股 | $0 | 0股 | +56.3万股 | 新买入 |
| Avidity Partners Management LP |
| 4.47% | 3.18% | #7 | $2,791.3万 | 55.0万股 | $1,568.0万 | 40.0万股 | +15.0万股+37.50% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.02% | — | #76 | $2,701.3万 | 53.2万股 | $0 | 0股 | +53.2万股 | 新买入 |
| Venrock Adviser, LLC |
| 0.81% | 2.53% | #27 | $2,671.1万 | 52.6万股 | $6,767.2万 | 172.6万股 | -120.0万股-69.51% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #144 | $2,587.9万 | 51.0万股 | $528.9万 | 25.8万股 | +25.2万股+97.35% | 加仓 |
| Affinity Asset Advisors, LLC |
| 1.15% | 1.19% | #22 | $2,537.5万 | 50.0万股 | $2,300.7万 | 58.7万股 | -8.7万股-14.81% | 减仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.58% | — | #13 | $2,483.6万 | 48.9万股 | $0 | 0股 | +48.9万股 | 新买入 |
| Logos Global Management LP |
| 1.02% | 2.04% | #24 | $2,359.9万 | 46.5万股 | $4,076.8万 | 104.0万股 | -57.5万股-55.29% | 减仓 |
| Rock Springs Capital Management LP |
| 1.15% | 1.91% | #21 | $2,358.0万 | 46.5万股 | $3,239.9万 | 82.7万股 | -36.2万股-43.78% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #130 | $2,237.8万 | 44.1万股 | $1,459.5万 | 37.2万股 | +6.9万股+18.43% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #125 | $2,154.0万 | 42.4万股 | $1,413.5万 | 36.1万股 | +6.4万股+17.71% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #103 | $2,087.7万 | 41.1万股 | $1,353.6万 | 34.5万股 | +6.6万股+19.13% | 加仓 |
| Nicholas Investment Partners, LP |
| 1.12% | 0.52% | #23 | $1,987.0万 | 39.2万股 | $716.3万 | 18.3万股 | +20.9万股+114.27% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.91% | 0.76% | #25 | $1,967.7万 | 38.8万股 | $1,291.8万 | 33.0万股 | +5.8万股+17.65% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #117 | $1,946.2万 | 38.3万股 | $0 | 0股 | +38.3万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #114 | $1,899.2万 | 37.4万股 | $415.1万 | 10.6万股 | +26.8万股+253.43% | 加仓 |
| Seven Fleet Capital Management LP |
| 3.06% | 2.04% | #11 | $1,854.3万 | 36.5万股 | $643.0万 | 16.4万股 | +20.1万股+122.76% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.05% | 0.04% | #65 | $1,761.7万 | 34.7万股 | $1,182.6万 | 30.2万股 | +4.5万股+15.07% | 加仓 |
| STEMPOINT CAPITAL LP |
| 2.51% | 2.63% | #15 | $1,760.6万 | 34.7万股 | $1,424.7万 | 36.3万股 | -1.7万股-4.55% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #135 | $1,736.2万 | 34.2万股 | $1,111.5万 | 28.4万股 | +5.9万股+20.66% | 加仓 |
| LORD, ABBETT & CO. LLC |
| 0.05% | — | #67 | $1,678.6万 | 33.1万股 | $0 | 0股 | +33.1万股 | 新买入 |
| Spruce Street Capital LP |
| 3.28% | 3.1% | #9 | $1,669.7万 | 32.9万股 | $1,289.7万 | 32.9万股 | 00.00% | 持仓不变 |
