| EcoR1 Capital, LLC |
| 29.2% | 24.41% | #1 | $6.00亿 | 2,297.0万股 | $5.75亿 | 2,297.0万股 | 00.00% | 持仓不变 |
| Rubric资本管理Rubric Capital Management LP |
| 1.68% | 1.86% | #4 | $1.83亿 | 700.0万股 | $1.75亿 | 700.0万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #80 | $1.11亿 | 425.1万股 | $1.14亿 | 455.4万股 | -30.3万股-6.65% | 减仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 1.64% | 1.72% | #6 | $1.09亿 | 418.3万股 | $8,789.2万 | 351.0万股 | +67.3万股+19.17% | 加仓 |
| BVF INC/IL |
| 2.44% | 2.98% | #3 | $9,538.9万 | 364.9万股 | $9,350.3万 | 373.4万股 | -8.5万股-2.28% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #65 | $5,832.5万 | 223.1万股 | $6,805.7万 | 398.5万股 | -175.3万股-44.00% | 减仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.05% | — | #32 | $4,655.8万 | 178.1万股 | $0 | 0股 | +178.1万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #105 | $4,075.2万 | 155.9万股 | $4,270.8万 | 170.6万股 | -14.7万股-8.59% | 减仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.04% | 0.03% | #36 | $3,272.8万 | 125.2万股 | $1,822.9万 | 72.8万股 | +52.4万股+71.99% | 加仓 |
| Nextech Invest Ltd. |
| 1.39% | 1.96% | #7 | $2,911.9万 | 111.4万股 | $2,789.3万 | 111.4万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #107 | $2,844.6万 | 108.8万股 | $2,533.5万 | 101.2万股 | +7.6万股+7.55% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | 0.01% | #59 | $2,599.6万 | 99.5万股 | $2,851.9万 | 113.9万股 | -14.4万股-12.66% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #69 | $2,526.0万 | 96.6万股 | $3,131.3万 | 125.1万股 | -28.4万股-22.73% | 减仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.03% | — | #38 | $2,325.9万 | 89.0万股 | $0 | 0股 | +89.0万股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #108 | $1,836.5万 | 70.3万股 | $1,670.6万 | 66.7万股 | +3.5万股+5.31% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #101 | $1,809.9万 | 69.2万股 | $1,652.4万 | 66.0万股 | +3.2万股+4.92% | 加仓 |
| Prosight Management, LP |
| 3.04% | 2.21% | #2 | $1,763.0万 | 67.4万股 | $1,349.8万 | 53.9万股 | +13.5万股+25.12% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #44 | $1,551.6万 | 59.4万股 | $1,281.9万 | 51.2万股 | +8.2万股+15.95% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #119 | $1,333.2万 | 51.0万股 | $1,251.7万 | 50.0万股 | +1.0万股+2.03% | 加仓 |
| Redmile Group, LLC |
| 0.86% | 0.82% | #10 | $1,285.2万 | 49.2万股 | $1,231.1万 | 49.2万股 | 00.00% | 持仓不变 |
| Capricorn Fund Managers Ltd |
| 1.01% | 3.93% | #8 | $1,271.8万 | 48.7万股 | $2,522.1万 | 100.7万股 | -52.1万股-51.70% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #93 | $1,230.7万 | 47.1万股 | $1,501.1万 | 59.9万股 | -12.9万股-21.46% | 减仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | 0.01% | #56 | $1,094.0万 | 41.8万股 | $1,862.7万 | 74.4万股 | -32.5万股-43.74% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | 0.01% | #67 | $1,038.3万 | 39.7万股 | $2,306.8万 | 92.1万股 | -52.4万股-56.89% | 减仓 |
| Hillsdale Investment Management Inc. |
| 0.23% | 0.24% | #16 | $1,001.0万 | 38.3万股 | $865.4万 | 34.6万股 | +3.7万股+10.79% | 加仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | — | #55 | $889.7万 | 34.0万股 | $0 | 0股 | +34.0万股 | 新买入 |
| Granahan 投资管理Granahan Investment Management, LLC |
| 0.31% | 0.3% | #13 | $878.7万 | 33.6万股 | $627.9万 | 25.1万股 | +8.5万股+34.05% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #99 | $839.3万 | 32.1万股 | $801.8万 | 32.0万股 | +863股+0.27% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.01% | <0.01% | #52 | $744.6万 | 30.8万股 | $23.2万 | 9,256股 | +29.9万股+3,229.59% | 加仓 |
| Picton Mahoney资产管理PICTON MAHONEY ASSET MANAGEMENT |
| 0.05% | 0.05% | #29 | $709.3万 | 27.1万股 | $642.8万 | 25.7万股 | +1.5万股+5.71% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #135 | $586.1万 | 22.4万股 | $688.4万 | 27.5万股 | -5.1万股-18.45% | 减仓 |
| Silvercrest资产管理集团SILVERCREST ASSET MANAGEMENT GROUP LLC |
| 0.04% | 0.03% | #37 | $584.9万 | 22.4万股 | $409.8万 | 16.4万股 | +6.0万股+36.74% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #144 | $572.7万 | 21.9万股 | $592.8万 | 23.7万股 | -1.8万股-7.47% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #102 | $567.8万 | 21.7万股 | $474.8万 | 19.0万股 | +2.8万股+14.53% | 加仓 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.14% | 0.25% | #21 | $551.0万 | 21.1万股 | $804.9万 | 32.1万股 | -11.1万股-34.42% | 减仓 |
| 英仕曼集团Man Group plc |
| 0.01% | 0.01% | #48 | $551.0万 | 21.1万股 | $475.5万 | 19.0万股 | +2.1万股+11.00% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.01% | 0.01% | #53 | $491.4万 | 18.8万股 | $456.8万 | 18.2万股 | +5,585股+3.06% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #89 | $435.0万 | 16.6万股 | $441.7万 | 17.6万股 | -9,995股-5.67% | 减仓 |
| 威斯康星州投资委员会STATE OF WISCONSIN INVESTMENT BOARD |
| 0.01% | <0.01% | #49 | $406.7万 | 15.6万股 | $165.5万 | 6.6万股 | +8.9万股+135.35% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #127 | $398.4万 | 15.2万股 | $463.6万 | 18.5万股 | -3.3万股-17.67% | 减仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.07% | 0.08% | #27 | $380.0万 | 14.5万股 | $371.2万 | 14.8万股 | -2,840股-1.92% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #76 | $378.5万 | 14.5万股 | $590.0万 | 23.6万股 | -9.1万股-38.54% | 减仓 |
| DIADEMA PARTNERS LP |
| 0.46% | 0.61% | #12 | $371.5万 | 14.2万股 | $355.9万 | 14.2万股 | 00.00% | 持仓不变 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #90 | $343.6万 | 13.1万股 | $286.3万 | 11.4万股 | +1.7万股+14.97% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #124 | $342.7万 | 13.1万股 | $310.8万 | 12.4万股 | +7,001股+5.64% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.04% | 0.06% | #35 | $329.0万 | 12.6万股 | $360.3万 | 14.4万股 | -1.8万股-12.51% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #109 | $312.1万 | 11.9万股 | $1,631.8万 | 65.2万股 | -53.2万股-81.68% | 减仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.01% | 0.02% | #45 | $310.0万 | 11.9万股 | $518.0万 | 20.7万股 | -8.8万股-42.66% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #143 | $300.9万 | 11.5万股 | $430.1万 | 17.2万股 | -5.7万股-33.00% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #154 | $293.3万 | 11.2万股 | $314.6万 | 12.6万股 | -1.3万股-10.68% | 减仓 |
