| GILEAD SCIENCES, INC. |
| 58.76% | 32.05% | #1 | $9.69亿 | 3,142.5万股 | $6.79亿 | 3,142.5万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #68 | $5.06亿 | 1,641.6万股 | $3.29亿 | 1,522.6万股 | +119.0万股+7.81% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #83 | $1.86亿 | 602.9万股 | $1.17亿 | 541.3万股 | +61.7万股+11.39% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.02% | #43 | $1.82亿 | 589.5万股 | $1.32亿 | 609.0万股 | -19.4万股-3.19% | 减仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 2.69% | 2.78% | #3 | $1.47亿 | 477.6万股 | $1.09亿 | 503.1万股 | -25.5万股-5.06% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #78 | $1.38亿 | 447.6万股 | $9,227.6万 | 427.2万股 | +20.3万股+4.76% | 加仓 |
| 富达投资FMR LLC |
| 0.01% | <0.01% | #84 | $1.25亿 | 405.0万股 | $2,516.9万 | 116.5万股 | +288.5万股+247.54% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #115 | $1.20亿 | 388.8万股 | $8,330.5万 | 385.7万股 | +3.2万股+0.82% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #61 | $9,749.2万 | 316.2万股 | $3,068.1万 | 142.0万股 | +174.2万股+122.63% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.29% | 0.31% | #22 | $9,273.0万 | 300.8万股 | $8,160.0万 | 377.8万股 | -77.0万股-20.38% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #97 | $7,550.8万 | 244.9万股 | $4,865.9万 | 225.2万股 | +19.6万股+8.72% | 加仓 |
| Siren, L.L.C. |
| 1.51% | 1.8% | #9 | $7,462.2万 | 242.0万股 | $6,495.3万 | 300.7万股 | -58.7万股-19.51% | 减仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.02% | 0.02% | #49 | $6,595.8万 | 213.9万股 | $4,731.3万 | 219.0万股 | -5.1万股-2.33% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.05% | 0.08% | #38 | $5,996.7万 | 194.5万股 | $8,124.7万 | 376.1万股 | -181.6万股-48.29% | 减仓 |
| 萨姆林资本SAMLYN CAPITAL, LLC |
| 0.78% | 0.7% | #16 | $4,770.0万 | 154.7万股 | $4,122.2万 | 190.8万股 | -36.1万股-18.93% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #65 | $4,422.2万 | 143.4万股 | $3,080.2万 | 142.6万股 | +8,097股+0.57% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.04% | — | #39 | $4,376.4万 | 142.0万股 | $0 | 0股 | +142.0万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $4,277.9万 | 138.8万股 | $2,159.5万 | 100.0万股 | +38.8万股+38.79% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 1.24% | 0.4% | #13 | $3,603.2万 | 116.9万股 | $976.3万 | 45.2万股 | +71.7万股+158.58% | 加仓 |
| Sofinnova Investments, Inc. |
| 1.51% | 0.76% | #10 | $2,915.6万 | 94.6万股 | $1,993.9万 | 92.3万股 | +2.3万股+2.45% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #98 | $2,903.4万 | 94.2万股 | $1,951.9万 | 90.4万股 | +3.8万股+4.22% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #106 | $2,875.0万 | 93.3万股 | $1,815.1万 | 84.0万股 | +9.2万股+10.97% | 加仓 |
| Parkman Healthcare Partners LLC |
| 2.9% | 2.69% | #2 | $2,834.1万 | 91.9万股 | $2,607.7万 | 120.7万股 | -28.8万股-23.86% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #121 | $2,605.9万 | 84.5万股 | $1,773.0万 | 82.1万股 | +2.4万股+2.97% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.13% | 0.05% | #25 | $2,604.6万 | 84.5万股 | $897.7万 | 41.6万股 | +42.9万股+103.27% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #129 | $2,575.9万 | 83.6万股 | $1,395.5万 | 64.6万股 | +18.9万股+29.32% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #138 | $2,453.8万 | 79.6万股 | $2,089.1万 | 153.6万股 | -74.0万股-48.19% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.09% | 0.09% | #29 | $2,038.9万 | 66.2万股 | $1,884.1万 | 79.1万股 | -12.9万股-16.27% | 减仓 |
| 安本标准投资Aberdeen Group plc |
| 0.03% | 0.03% | #44 | $2,006.1万 | 65.1万股 | $1,662.7万 | 77.0万股 | -11.9万股-15.47% | 减仓 |
| Logos Global Management LP |
| 0.86% | 1.29% | #15 | $2,004.0万 | 65.0万股 | $2,592.0万 | 120.0万股 | -55.0万股-45.83% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #55 | $1,959.0万 | 63.5万股 | $675.4万 | 31.3万股 | +32.3万股+103.21% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #96 | $1,899.4万 | 61.6万股 | $1,259.1万 | 58.3万股 | +3.3万股+5.69% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.01% | — | #59 | $1,817.6万 | 59.0万股 | $0 | 0股 | +59.0万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #114 | $1,674.1万 | 54.3万股 | $1,104.1万 | 51.1万股 | +3.2万股+6.23% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.06% | 0.04% | #33 | $1,578.8万 | 51.2万股 | $929.5万 | 43.0万股 | +8.2万股+18.99% | 加仓 |
| Ikarian Capital, LLC |
| 1.65% | — | #8 | $1,555.6万 | 50.5万股 | $0 | 0股 | +50.5万股 | 新买入 |
| Decheng Capital LLC |
| 1.96% | 1.56% | #6 | $1,432.9万 | 46.5万股 | $1,032.1万 | 47.8万股 | -1.3万股-2.73% | 减仓 |
| DAFNA Capital Management LLC |
| 2.6% | 2.18% | #4 | $1,362.2万 | 44.2万股 | $958.7万 | 44.4万股 | -2,000股-0.45% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #157 | $1,312.1万 | 41.8万股 | $166.9万 | 8.1万股 | +33.7万股+417.52% | 加仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | <0.01% | #76 | $1,305.2万 | 42.3万股 | $893.8万 | 41.4万股 | +9,588股+2.32% | 加仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.02% | 0.01% | #51 | $1,168.8万 | 37.9万股 | $818.9万 | 37.9万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #133 | $1,137.8万 | 36.9万股 | $623.9万 | 28.9万股 | +8.0万股+27.76% | 加仓 |
| Patient Square Capital LP |
| 1.7% | 0.75% | #7 | $1,096.9万 | 35.6万股 | $421.2万 | 19.5万股 | +16.1万股+82.46% | 加仓 |
| DIADEMA PARTNERS LP |
| 1.32% | 0.88% | #12 | $1,072.3万 | 34.8万股 | $514.4万 | 23.8万股 | +11.0万股+46.05% | 加仓 |
| PDT Partners, LLC |
| 0.52% | 0.5% | #18 | $997.6万 | 32.4万股 | $838.8万 | 38.8万股 | -6.5万股-16.68% | 减仓 |
| 加拿大公共部门养老金投资委员会(PSP)PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.02% | 0.02% | #47 | $919.2万 | 29.8万股 | $655.2万 | 30.3万股 | -5,160股-1.70% | 减仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| <0.01% | <0.01% | #90 | $836.8万 | 27.1万股 | $28.3万 | 1.3万股 | +25.8万股+1,972.33% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #126 | $721.6万 | 23.4万股 | $478.9万 | 22.2万股 | +1.2万股+5.57% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #58 | $693.7万 | 22.5万股 | $608.4万 | 28.2万股 | -5.7万股-20.12% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #165 | $691.8万 | 22.4万股 | $467.6万 | 21.6万股 | +7,917股+3.66% | 加仓 |
