| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #133 | $1.97亿 | 1,321.1万股 | $9,494.2万 | 1,122.2万股 | +198.8万股+17.72% | 加仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 2.8% | 2.22% | #7 | $1.53亿 | 1,028.7万股 | $8,702.7万 | 1,028.7万股 | 00.00% | 持仓不变 |
| Stifel金融STIFEL FINANCIAL CORP |
| 0.12% | 0.08% | #42 | $1.48亿 | 994.1万股 | $8,410.0万 | 994.1万股 | +280股+0.00% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.05% | — | #54 | $1.28亿 | 858.5万股 | $0 | 0股 | +858.5万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.35% | 0.01% | #21 | $1.14亿 | 766.0万股 | $254.1万 | 30.0万股 | +736.0万股+2,450.12% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #130 | $1.03亿 | 694.7万股 | $5,599.5万 | 661.9万股 | +32.8万股+4.96% | 加仓 |
| INFINITUM ASSET MANAGEMENT, LLC |
| 9.46% | 6.6% | #2 | $9,300.0万 | 625.0万股 | $5,287.5万 | 625.0万股 | 00.00% | 持仓不变 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.03% | 0.01% | #67 | $6,235.0万 | 419.0万股 | $2,408.7万 | 284.7万股 | +134.3万股+47.17% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.02% | 0.01% | #74 | $6,176.1万 | 415.1万股 | $1,671.3万 | 197.6万股 | +217.5万股+110.10% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #141 | $4,946.0万 | 332.3万股 | $2,342.0万 | 276.8万股 | +55.5万股+20.07% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #165 | $4,411.4万 | 296.5万股 | $1,995.8万 | 235.9万股 | +60.6万股+25.67% | 加仓 |
| Royalty Pharma Sub-Manager, LLC |
| 18.06% | 14.38% | #1 | $4,369.5万 | 293.7万股 | $2,484.3万 | 293.7万股 | 00.00% | 持仓不变 |
| Cormorant Asset Management, LP |
| 1.97% | 0.75% | #10 | $3,883.7万 | 261.0万股 | $1,489.0万 | 176.0万股 | +85.0万股+48.30% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #125 | $3,843.6万 | 258.3万股 | $2,126.2万 | 251.3万股 | +7.0万股+2.78% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #112 | $3,748.0万 | 251.9万股 | $1,206.8万 | 142.6万股 | +109.2万股+76.58% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #173 | $3,703.5万 | 248.9万股 | $1,928.3万 | 227.9万股 | +21.0万股+9.20% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #123 | $3,040.5万 | 204.3万股 | $1,653.4万 | 195.4万股 | +8.9万股+4.55% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.03% | #62 | $2,797.0万 | 188.0万股 | $2,068.8万 | 244.5万股 | -56.6万股-23.13% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.64% | 1.12% | #15 | $2,648.6万 | 178.0万股 | $3,918.1万 | 463.1万股 | -285.1万股-61.57% | 减仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #99 | $2,595.6万 | 174.4万股 | $630.9万 | 74.6万股 | +99.9万股+133.90% | 加仓 |
| Rubric资本管理Rubric Capital Management LP |
| 0.23% | — | #27 | $2,561.6万 | 172.1万股 | $0 | 0股 | +172.1万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #209 | $2,215.3万 | 148.9万股 | $1,074.3万 | 127.0万股 | +21.9万股+17.24% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #177 | $2,199.0万 | 147.8万股 | $642.5万 | 75.9万股 | +71.8万股+94.60% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #151 | $2,167.8万 | 145.7万股 | $1,875.8万 | 221.7万股 | -76.0万股-34.29% | 减仓 |
| ARS Investment Partners, LLC |
| 0.89% | 0.61% | #13 | $2,044.8万 | 137.4万股 | $1,166.5万 | 137.9万股 | -4,643股-0.34% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.01% | #89 | $1,821.9万 | 122.4万股 | $1,306.5万 | 154.4万股 | -32.0万股-20.72% | 减仓 |
| 资本研究全球投资者Capital Research Global Investors |
| <0.01% | <0.01% | #145 | $1,784.9万 | 120.0万股 | $1,127.5万 | 133.3万股 | -13.3万股-10.00% | 减仓 |
| MYDA Advisors LLC |
| 2.64% | 1.7% | #8 | $1,770.7万 | 119.0万股 | $1,036.4万 | 122.5万股 | -3.5万股-2.86% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #179 | $1,767.1万 | 118.8万股 | $1,310.2万 | 154.9万股 | -36.1万股-23.32% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #157 | $1,765.1万 | 118.6万股 | $847.2万 | 100.1万股 | +18.5万股+18.45% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #148 | $1,650.6万 | 110.9万股 | $796.2万 | 94.1万股 | +16.8万股+17.87% | 加仓 |
| STEMPOINT CAPITAL LP |
| 2.33% | 2.49% | #9 | $1,636.0万 | 156.4万股 | $1,348.9万 | 159.4万股 | -3.0万股-1.90% | 减仓 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.22% | 0.12% | #28 | $1,547.9万 | 104.0万股 | $760.0万 | 89.8万股 | +14.2万股+15.79% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #77 | $1,488.0万 | 100.0万股 | $1,267.1万 | 149.8万股 | -49.8万股-33.24% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #82 | $1,348.0万 | 90.6万股 | $1,303.2万 | 154.0万股 | -63.5万股-41.19% | 减仓 |
| Voloridge投资管理VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.06% | 0.04% | #52 | $1,313.5万 | 88.3万股 | $1,032.0万 | 122.0万股 | -33.7万股-27.64% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #202 | $1,251.9万 | 84.1万股 | $819.3万 | 54.6万股 | +29.6万股+54.15% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #140 | $1,233.2万 | 82.9万股 | $593.5万 | 70.2万股 | +12.7万股+18.13% | 加仓 |
| Ikarian Capital, LLC |
| 1.18% | 0.28% | #12 | $1,113.3万 | 74.8万股 | $349.0万 | 41.2万股 | +33.6万股+81.39% | 加仓 |
| 奥地利Erste资产管理Erste Asset Management GmbH |
| 0.09% | 0.05% | #46 | $1,102.3万 | 73.7万股 | $560.9万 | 69.3万股 | +4.4万股+6.35% | 加仓 |
| 5AM Venture Management, LLC |
| 3.82% | 1.74% | #5 | $1,099.6万 | 73.9万股 | $625.2万 | 73.9万股 | 00.00% | 持仓不变 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.41% | 0.4% | #18 | $1,041.6万 | 70.0万股 | $846.0万 | 100.0万股 | -30.0万股-30.00% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | <0.01% | #93 | $969.2万 | 65.1万股 | $298.3万 | 35.3万股 | +29.9万股+84.72% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.04% | 0.02% | #59 | $922.6万 | 62.0万股 | $347.1万 | 41.0万股 | +21.0万股+51.09% | 加仓 |
| Longaeva 合伙人Longaeva Partners L.P. |
| 0.2% | — | #32 | $892.7万 | 60.0万股 | $0 | 0股 | +60.0万股 | 新买入 |
| Sarissa Capital Management LP |
| 4.87% | 3.02% | #3 | $866.5万 | 58.2万股 | $476.5万 | 56.3万股 | +1.9万股+3.40% | 加仓 |
| PFIZER INC |
| 4.7% | 1.77% | #4 | $800.4万 | 50.6万股 | $423.2万 | 50.6万股 | 00.00% | 持仓不变 |
| Eversept Partners, LP |
| 0.4% | — | #19 | $767.5万 | 51.6万股 | $0 | 0股 | +51.6万股 | 新买入 |
| Trexquant投资Trexquant Investment LP |
| 0.04% | 0.05% | #57 | $749.5万 | 50.4万股 | $742.6万 | 87.8万股 | -37.4万股-42.62% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.34% | 0.02% | #22 | $746.5万 | 50.2万股 | $37.9万 | 4.5万股 | +45.7万股+1,020.41% | 加仓 |
