| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.36% | 2.07% | #6 | $1.57亿 | 2,697.6万股 | $1.96亿 | 2,697.6万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #106 | $1.12亿 | 1,920.2万股 | $1.02亿 | 1,411.7万股 | +508.5万股+36.02% | 加仓 |
| GSK plc |
| 17.6% | 22.08% | #2 | $1.06亿 | 1,824.6万股 | $1.32亿 | 1,824.6万股 | 00.00% | 持仓不变 |
| Maverick资本MAVERICK CAPITAL LTD |
| 0.53% | 0.95% | #7 | $5,971.6万 | 1,027.8万股 | $8,205.1万 | 1,131.7万股 | -103.9万股-9.18% | 减仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.18% | 0.29% | #14 | $3,162.5万 | 544.3万股 | $3,937.5万 | 543.1万股 | +1.2万股+0.22% | 加仓 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| 0.02% | 0.03% | #54 | $3,111.0万 | 535.5万股 | $3,503.9万 | 483.3万股 | +52.2万股+10.79% | 加仓 |
| 683 Capital Management, LLC |
| 1.41% | 1.85% | #4 | $2,876.0万 | 495.0万股 | $3,552.5万 | 490.0万股 | +5.0万股+1.02% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #113 | $2,860.0万 | 492.2万股 | $3,764.8万 | 519.3万股 | -27.0万股-5.21% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #129 | $2,811.6万 | 483.9万股 | $2,663.7万 | 367.4万股 | +116.5万股+31.72% | 加仓 |
| M28 Capital Management LP |
| 56.53% | 61.83% | #1 | $2,665.8万 | 458.8万股 | $3,326.5万 | 458.8万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #116 | $2,248.9万 | 387.0万股 | $2,595.4万 | 357.9万股 | +29.1万股+8.13% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.01% | #58 | $2,154.2万 | 370.8万股 | $1,361.6万 | 187.8万股 | +183.0万股+97.42% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.19% | 0.14% | #13 | $1,637.0万 | 281.8万股 | $953.8万 | 131.6万股 | +150.2万股+114.17% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #59 | $1,612.9万 | 277.6万股 | $113.0万 | 15.6万股 | +262.0万股+1,680.35% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.02% | 0.02% | #57 | $1,476.6万 | 254.1万股 | $1,386.5万 | 191.2万股 | +62.9万股+32.89% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #136 | $1,407.6万 | 242.3万股 | $371.3万 | 50.7万股 | +191.5万股+377.58% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #142 | $1,226.3万 | 211.1万股 | $852.8万 | 117.6万股 | +93.5万股+79.45% | 加仓 |
| PFIZER INC |
| 6.42% | 5% | #3 | $1,093.1万 | 187.5万股 | $1,193.4万 | 187.5万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $1,052.4万 | 181.1万股 | $704.9万 | 97.2万股 | +83.9万股+86.30% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #120 | $1,049.6万 | 180.6万股 | $6,310.9万 | 870.5万股 | -689.8万股-79.25% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #78 | $1,029.7万 | 177.2万股 | $52.4万 | 7.2万股 | +170.0万股+2,351.04% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #180 | $1,017.6万 | 175.1万股 | $1,168.6万 | 161.2万股 | +14.0万股+8.66% | 加仓 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.01% | 0.01% | #74 | $992.1万 | 174.7万股 | $954.0万 | 144.1万股 | +30.6万股+21.21% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #100 | $992.0万 | 170.8万股 | $0 | 0股 | +170.8万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #60 | $990.3万 | 170.5万股 | $433.0万 | 59.7万股 | +110.7万股+185.41% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $957.5万 | 164.8万股 | $327.1万 | 45.1万股 | +119.7万股+265.27% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #132 | $942.6万 | 162.2万股 | $1,003.1万 | 138.4万股 | +23.9万股+17.26% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #68 | $864.4万 | 148.8万股 | $26.5万 | 3.7万股 | +145.1万股+3,965.00% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.01% | 0.06% | #65 | $851.9万 | 146.6万股 | $3,855.2万 | 531.7万股 | -385.1万股-72.43% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.07% | 0.1% | #31 | $784.4万 | 135.0万股 | $978.8万 | 135.0万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #128 | $728.3万 | 125.4万股 | $862.2万 | 118.9万股 | +6.4万股+5.40% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #123 | $711.4万 | 122.4万股 | $855.0万 | 117.9万股 | +4.5万股+3.83% | 加仓 |
| EMERALD ADVISERS, LLC |
| 0.17% | 0.29% | #18 | $711.1万 | 122.4万股 | $914.4万 | 126.1万股 | -3.7万股-2.95% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | 0.01% | #80 | $580.7万 | 100.0万股 | $1,297.7万 | 179.0万股 | -79.0万股-44.16% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.01% | 0.01% | #77 | $533.0万 | 91.7万股 | $820.2万 | 114.9万股 | -23.2万股-20.16% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #118 | $515.7万 | 88.8万股 | $637.2万 | 87.9万股 | +8,844股+1.01% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.01% | 0.01% | #73 | $509.2万 | 87.6万股 | $398.8万 | 55.0万股 | +32.6万股+59.36% | 加仓 |
| EMERALD MUTUAL FUND ADVISERS 信托EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.17% | 0.29% | #17 | $492.7万 | 84.8万股 | $590.5万 | 81.5万股 | +3.3万股+4.11% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.02% | 0.03% | #47 | $478.0万 | 82.3万股 | $596.4万 | 82.3万股 | 00.00% | 持仓不变 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #95 | $471.2万 | 81.1万股 | $203.7万 | 28.1万股 | +53.0万股+188.61% | 加仓 |
| Capital基金管理CAPITAL FUND MANAGEMENT S.A. |
| 0.02% | 0.01% | #52 | $426.9万 | 73.5万股 | $132.9万 | 18.3万股 | +55.1万股+300.78% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.01% | 0.02% | #62 | $373.1万 | 64.2万股 | $386.8万 | 53.4万股 | +10.9万股+20.36% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.48% | 0.63% | #8 | $370.8万 | 63.8万股 | $397.5万 | 54.8万股 | +9.0万股+16.42% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #151 | $359.5万 | 61.9万股 | $2,043.2万 | 281.8万股 | -219.9万股-78.04% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #186 | $354.7万 | 61.8万股 | $443.7万 | 67.0万股 | -5.2万股-7.76% | 减仓 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.07% | 0.02% | #28 | $354.5万 | 61.0万股 | $113.8万 | 15.7万股 | +45.3万股+288.56% | 加仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.06% | 0.02% | #34 | $353.4万 | 60.8万股 | $142.0万 | 19.6万股 | +41.2万股+210.56% | 加仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 0.16% | 0.22% | #19 | $348.6万 | 60.0万股 | $435.0万 | 60.0万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #147 | $346.6万 | 59.7万股 | $390.8万 | 53.9万股 | +5.8万股+10.69% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #134 | $319.1万 | 54.9万股 | $476.8万 | 65.8万股 | -10.8万股-16.49% | 减仓 |
