| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.27% | 0.25% | #19 | $4.17亿 | 1,967.7万股 | $3.58亿 | 1,636.4万股 | +331.3万股+20.24% | 加仓 |
| 富达投资FMR LLC |
| 0.02% | 0.02% | #52 | $3.60亿 | 1,698.8万股 | $3.71亿 | 1,697.0万股 | +1.8万股+0.10% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #96 | $1.87亿 | 880.5万股 | $1.79亿 | 816.9万股 | +63.7万股+7.80% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #85 | $1.16亿 | 549.5万股 | $1.18亿 | 540.0万股 | +9.5万股+1.75% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.02% | #50 | $1.10亿 | 521.0万股 | $1.03亿 | 473.2万股 | +47.8万股+10.11% | 加仓 |
| Redmile Group, LLC |
| 6.99% | 8.05% | #2 | $1.04亿 | 491.2万股 | $1.22亿 | 555.9万股 | -64.7万股-11.64% | 减仓 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| 0.06% | 0.08% | #34 | $9,708.1万 | 458.1万股 | $1.05亿 | 478.8万股 | -20.7万股-4.32% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #109 | $9,644.2万 | 455.1万股 | $9,687.7万 | 443.0万股 | +12.2万股+2.74% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.53% | 0.66% | #11 | $9,209.5万 | 434.6万股 | $8,966.5万 | 410.0万股 | +24.6万股+6.01% | 加仓 |
| Enavate Sciences GP, LLC |
| 22.17% | 22.48% | #1 | $7,657.6万 | 361.4万股 | $7,903.4万 | 361.4万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #90 | $5,838.8万 | 275.5万股 | $5,601.3万 | 256.1万股 | +19.4万股+7.58% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #98 | $5,102.4万 | 240.8万股 | $2,147.4万 | 183.4万股 | +57.4万股+31.31% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 4.44% | 4.13% | #4 | $4,274.0万 | 201.7万股 | $4,046.6万 | 185.0万股 | +16.7万股+9.01% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #105 | $3,899.0万 | 184.9万股 | $5,361.2万 | 277.8万股 | -92.9万股-33.45% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #81 | $3,757.5万 | 177.3万股 | $6,252.5万 | 285.9万股 | -108.6万股-37.97% | 减仓 |
| Sofinnova Investments, Inc. |
| 1.88% | 1.41% | #5 | $3,645.3万 | 172.0万股 | $3,722.1万 | 170.2万股 | +1.8万股+1.08% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #95 | $3,205.0万 | 151.2万股 | $2,408.9万 | 110.1万股 | +41.1万股+37.31% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #125 | $2,858.5万 | 134.9万股 | $2,202.3万 | 100.7万股 | +34.2万股+33.96% | 加仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | 0.02% | #53 | $2,855.1万 | 134.7万股 | $3,011.2万 | 137.7万股 | -3.0万股-2.14% | 减仓 |
| READYSTATE 资产管理READYSTATE ASSET MANAGEMENT LP |
| 1.45% | 1.28% | #7 | $2,847.2万 | 130.2万股 | $2,847.2万 | 130.2万股 | 00.00% | 持仓不变 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.03% | — | #46 | $2,649.3万 | 125.0万股 | $0 | 0股 | +125.0万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.07% | 0.13% | #31 | $2,119.8万 | 100.0万股 | $3,445.4万 | 157.5万股 | -57.5万股-36.50% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #102 | $2,051.9万 | 96.8万股 | $1,966.4万 | 89.9万股 | +6.9万股+7.70% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #101 | $1,877.8万 | 88.6万股 | $1,862.9万 | 85.2万股 | +3.4万股+4.04% | 加仓 |
| 大都会人寿投资管理MetLife Investment Management, LLC |
| 0.08% | 0.01% | #30 | $1,820.4万 | 85.9万股 | $122.2万 | 5.6万股 | +80.3万股+1,437.99% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #84 | $1,602.6万 | 75.6万股 | $1,566.8万 | 71.6万股 | +4.0万股+5.57% | 加仓 |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 5.04% | 5.73% | #3 | $1,552.2万 | 73.3万股 | $1,602.0万 | 73.3万股 | 00.00% | 持仓不变 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #55 | $1,524.1万 | 71.9万股 | $1,519.8万 | 69.5万股 | +2.4万股+3.50% | 加仓 |
| NAN FUNG TRINITY (HK) Ltd |
| 1.5% | 1.72% | #6 | $1,514.1万 | 71.5万股 | $1,562.7万 | 71.5万股 | 00.00% | 持仓不变 |
| 康得利安资管Candriam S.C.A. |
| 0.07% | 0.06% | #32 | $1,439.8万 | 68.0万股 | $1,159.7万 | 54.0万股 | +14.0万股+25.98% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #136 | $1,372.9万 | 64.8万股 | $1,709.4万 | 78.2万股 | -13.4万股-17.11% | 减仓 |
| Parkman Healthcare Partners LLC |
| 1.29% | 0.91% | #8 | $1,259.1万 | 59.4万股 | $882.4万 | 40.3万股 | +19.1万股+47.27% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.03% | #65 | $1,060.6万 | 50.1万股 | $3,238.5万 | 148.1万股 | -98.0万股-66.20% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #63 | $930.6万 | 43.9万股 | $411.7万 | 18.8万股 | +25.1万股+133.33% | 加仓 |
| ALERUS FINANCIAL NA |
| 0.36% | — | #17 | $812.5万 | 38.3万股 | $0 | 0股 | +38.3万股 | 新买入 |
| Granahan 投资管理Granahan Investment Management, LLC |
| 0.29% | 0.32% | #18 | $802.1万 | 37.9万股 | $671.5万 | 30.7万股 | +7.2万股+23.30% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #121 | $779.7万 | 36.8万股 | $73.1万 | 3.3万股 | +33.5万股+1,001.43% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #82 | $762.4万 | 36.0万股 | $793.1万 | 36.3万股 | -2,841股-0.78% | 减仓 |
| Rock Springs Capital Management LP |
| 0.36% | 0.45% | #16 | $736.7万 | 34.8万股 | $760.3万 | 34.8万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #135 | $696.1万 | 32.8万股 | $946.8万 | 43.3万股 | -10.4万股-24.12% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #137 | $642.6万 | 30.3万股 | $384.2万 | 17.6万股 | +12.8万股+72.61% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #129 | $633.3万 | 29.9万股 | $603.8万 | 27.6万股 | +2.3万股+8.26% | 加仓 |
| Atom Investors LP |
| 0.56% | 0.48% | #9 | $630.4万 | 29.7万股 | $671.1万 | 30.7万股 | -9,391股-3.06% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #120 | $612.2万 | 28.9万股 | $667.6万 | 30.5万股 | -1.6万股-5.35% | 减仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.1% | 0.13% | #28 | $587.1万 | 27.7万股 | $627.7万 | 28.7万股 | -9,966股-3.47% | 减仓 |
| Tidal投资Tidal Investments LLC |
| 0.01% | 0.01% | #61 | $568.2万 | 26.8万股 | $603.4万 | 27.6万股 | -7,729股-2.80% | 减仓 |
| TEMA ETFS LLC |
| 0.18% | 0.41% | #21 | $568.2万 | 26.8万股 | $603.4万 | 27.6万股 | -7,729股-2.80% | 减仓 |
| Atika Capital Management LLC |
| 0.54% | 0.72% | #10 | $557.1万 | 26.3万股 | $575.0万 | 26.3万股 | 00.00% | 持仓不变 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| <0.01% | — | #88 | $556.9万 | 26.3万股 | $0 | 0股 | +26.3万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #67 | $532.1万 | 25.1万股 | $150.7万 | 6.9万股 | +18.2万股+264.43% | 加仓 |
