| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #107 | $1.37亿 | 481.5万股 | $7,850.4万 | 452.2万股 | +29.3万股+6.47% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #104 | $7,036.2万 | 246.9万股 | $4,792.0万 | 276.0万股 | -29.2万股-10.56% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #122 | $6,262.8万 | 219.7万股 | $3,750.6万 | 216.0万股 | +3.7万股+1.71% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.59% | 0.45% | #11 | $5,693.2万 | 199.8万股 | $3,803.6万 | 219.1万股 | -19.3万股-8.83% | 减仓 |
| ARK投资管理ARK Investment Management LLC |
| 0.36% | 0.3% | #20 | $5,567.6万 | 195.4万股 | $3,867.0万 | 222.8万股 | -27.4万股-12.30% | 减仓 |
| 波士顿合伙人Boston Partners |
| 0.05% | 0.03% | #39 | $5,522.5万 | 193.8万股 | $3,270.5万 | 188.4万股 | +5.4万股+2.87% | 加仓 |
| BAMCO(巴伦基金)BAMCO INC /NY/ |
| 0.08% | 0.17% | #37 | $5,521.4万 | 193.7万股 | $5,792.0万 | 333.6万股 | -139.9万股-41.93% | 减仓 |
| GAGNON SECURITIES LLC |
| 9.81% | 7.06% | #3 | $5,046.6万 | 177.1万股 | $3,058.6万 | 176.2万股 | +8,861股+0.50% | 加仓 |
| Chevy Chase信托控股Chevy Chase Trust Holdings, LLC |
| 0.11% | 0.08% | #31 | $4,096.6万 | 143.7万股 | $2,611.1万 | 150.4万股 | -6.7万股-4.43% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $3,785.6万 | 132.8万股 | $2,177.5万 | 125.4万股 | +7.4万股+5.89% | 加仓 |
| Ophir Asset Management Pty Ltd |
| 2.96% | 2% | #4 | $3,604.7万 | 126.5万股 | $1,715.3万 | 98.8万股 | +27.7万股+28.01% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.05% | 0.03% | #40 | $3,542.4万 | 124.3万股 | $2,056.1万 | 118.4万股 | +5.9万股+4.94% | 加仓 |
| BRAIDWELL LP |
| 1.29% | 1.26% | #7 | $3,478.7万 | 122.1万股 | $3,772.6万 | 217.3万股 | -95.3万股-43.83% | 减仓 |
| 三井住友信托集团Sumitomo Mitsui Trust Group, Inc. |
| 0.02% | 0.02% | #51 | $3,396.1万 | 119.2万股 | $2,560.8万 | 147.5万股 | -28.3万股-19.22% | 减仓 |
| Blue Water Life Science Advisors, LP |
| 21.36% | 13.02% | #1 | $3,391.5万 | 119.0万股 | $1,623.2万 | 93.5万股 | +25.5万股+27.27% | 加仓 |
| Amova资产管理Amova Asset Management Americas, Inc. |
| 0.44% | 0.36% | #17 | $3,384.8万 | 118.8万股 | $2,560.8万 | 147.5万股 | -28.7万股-19.46% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #74 | $3,366.4万 | 118.1万股 | $2,537.5万 | 146.2万股 | -28.1万股-19.21% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.02% | 0.01% | #54 | $3,242.3万 | 113.8万股 | $1,518.8万 | 87.5万股 | +26.3万股+30.03% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.1% | 0.06% | #32 | $2,837.7万 | 99.6万股 | $1,500.7万 | 86.4万股 | +13.1万股+15.18% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #124 | $2,820.2万 | 99.0万股 | $1,478.1万 | 85.1万股 | +13.8万股+16.22% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #128 | $2,206.8万 | 77.4万股 | $707.1万 | 48.6万股 | +28.8万股+59.22% | 加仓 |
| Divisadero Street 资本管理Divisadero Street Capital Management, LP |
| 0.45% | — | #16 | $1,997.7万 | 70.1万股 | $0 | 0股 | +70.1万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #112 | $1,995.0万 | 70.0万股 | $1,273.1万 | 73.3万股 | -3.3万股-4.55% | 减仓 |
| Portolan 资本管理Portolan Capital Management, LLC |
| 0.73% | 0.31% | #10 | $1,951.7万 | 68.5万股 | $590.9万 | 34.0万股 | +34.4万股+101.20% | 加仓 |
| 第一鹰投资管理First Eagle Investment Management, LLC |
| 0.03% | 0.02% | #47 | $1,705.7万 | 59.8万股 | $998.8万 | 57.5万股 | +2.3万股+4.02% | 加仓 |
| Royce联营ROYCE & ASSOCIATES LP |
| 0.13% | 0.09% | #25 | $1,641.5万 | 57.6万股 | $960.4万 | 55.3万股 | +2.3万股+4.12% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #133 | $1,629.7万 | 57.2万股 | $817.1万 | 47.1万股 | +10.1万股+21.49% | 加仓 |
| Gagnon Advisors, LLC |
| 9.91% | 6.81% | #2 | $1,558.6万 | 54.7万股 | $925.1万 | 53.3万股 | +1.4万股+2.63% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #106 | $1,533.7万 | 53.8万股 | $886.1万 | 51.0万股 | +2.8万股+5.43% | 加仓 |
| Palo Alto Investors LP |
| 2.22% | 1.41% | #6 | $1,515.8万 | 53.2万股 | $923.3万 | 53.2万股 | 00.00% | 持仓不变 |
| 罗素投资集团Russell Investments Group, Ltd. |
| 0.01% | 0.01% | #60 | $1,463.6万 | 51.4万股 | $969.3万 | 55.8万股 | -4.5万股-8.02% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #130 | $1,367.6万 | 48.0万股 | $434.6万 | 25.0万股 | +23.0万股+91.68% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #116 | $1,364.6万 | 47.9万股 | $789.0万 | 45.5万股 | +2.4万股+5.34% | 加仓 |
| Meridiem Capital Partners LP |
| 0.58% | 0.36% | #13 | $1,286.8万 | 45.1万股 | $550.2万 | 31.7万股 | +13.5万股+42.45% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #136 | $1,274.5万 | 44.7万股 | $841.9万 | 48.5万股 | -3.8万股-7.78% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #68 | $1,145.7万 | 40.2万股 | $402.1万 | 23.2万股 | +17.0万股+73.57% | 加仓 |
| Zweig-DiMenna Associates LLC |
| 1.01% | 0.94% | #8 | $1,108.1万 | 38.9万股 | $677.5万 | 39.0万股 | -1,443股-0.37% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #78 | $1,068.5万 | 37.5万股 | $795.6万 | 45.8万股 | -8.3万股-18.20% | 减仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #83 | $1,060.5万 | 37.2万股 | $0 | 0股 | +37.2万股 | 新买入 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | — | #65 | $1,054.0万 | 37.0万股 | $0 | 0股 | +37.0万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #102 | $1,044.6万 | 36.7万股 | $611.9万 | 35.2万股 | +1.4万股+3.99% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| <0.01% | — | #87 | $967.3万 | 33.9万股 | $0 | 0股 | +33.9万股 | 新买入 |
| ArrowMark Colorado Holdings LLC |
| 0.4% | 0.22% | #19 | $964.9万 | 33.9万股 | $844.9万 | 48.7万股 | -14.8万股-30.44% | 减仓 |
| Silvercrest资产管理集团SILVERCREST ASSET MANAGEMENT GROUP LLC |
| 0.06% | 0.04% | #38 | $844.2万 | 29.6万股 | $539.1万 | 31.1万股 | -1.4万股-4.62% | 减仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #56 | $764.4万 | 26.8万股 | $642.6万 | 37.0万股 | -10.2万股-27.55% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #171 | $721.9万 | 25.3万股 | $401.5万 | 23.1万股 | +2.2万股+9.52% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #100 | $696.5万 | 24.4万股 | $606.3万 | 34.9万股 | -10.5万股-30.02% | 减仓 |
| 安本标准投资Aberdeen Group plc |
| 0.01% | 0.01% | #66 | $640.8万 | 22.5万股 | $725.2万 | 41.8万股 | -19.3万股-46.18% | 减仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.04% | — | #44 | $610.9万 | 21.4万股 | $0 | 0股 | +21.4万股 | 新买入 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | <0.01% | #125 | $604.1万 | 21.2万股 | $364.1万 | 21.0万股 | +2,204股+1.05% | 加仓 |
