| EcoR1 Capital, LLC |
| 25.86% | 18.55% | #1 | $5.32亿 | 788.0万股 | $4.37亿 | 788.0万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #107 | $1.24亿 | 184.4万股 | $9,324.9万 | 168.1万股 | +16.3万股+9.67% | 加仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 4.08% | 3.75% | #5 | $8,983.4万 | 133.1万股 | $7,381.1万 | 133.1万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #96 | $8,681.8万 | 128.6万股 | $5,504.1万 | 99.2万股 | +29.4万股+29.60% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #119 | $6,117.1万 | 90.6万股 | $4,731.6万 | 85.3万股 | +5.3万股+6.22% | 加仓 |
| Affinity Asset Advisors, LLC |
| 2.52% | 2.69% | #7 | $5,576.2万 | 82.6万股 | $5,213.2万 | 94.0万股 | -11.4万股-12.12% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.02% | 0.01% | #45 | $5,550.6万 | 82.2万股 | $2,637.5万 | 47.6万股 | +34.7万股+72.91% | 加仓 |
| Sanofi |
| 10.39% | 9.04% | #2 | $5,547.9万 | 82.2万股 | $3,038.5万 | 82.2万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.15% | 0.07% | #24 | $4,839.8万 | 71.7万股 | $1,909.2万 | 34.4万股 | +37.3万股+108.28% | 加仓 |
| 683 Capital Management, LLC |
| 2.19% | 1.81% | #9 | $4,455.0万 | 66.0万股 | $3,466.3万 | 62.5万股 | +3.5万股+5.60% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #99 | $4,306.4万 | 63.8万股 | $2,885.9万 | 52.0万股 | +11.8万股+22.61% | 加仓 |
| Palo Alto Investors LP |
| 5.95% | 5.41% | #4 | $4,073.6万 | 60.3万股 | $3,539.2万 | 63.8万股 | -3.5万股-5.43% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #86 | $3,942.5万 | 58.4万股 | $1,845.4万 | 33.3万股 | +25.1万股+75.53% | 加仓 |
| First Light Asset Management, LLC |
| 2.39% | 2.81% | #8 | $3,928.5万 | 58.2万股 | $3,135.9万 | 56.5万股 | +1.7万股+2.93% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.02% | 0.02% | #49 | $3,642.7万 | 54.0万股 | $3,212.8万 | 57.9万股 | -4.0万股-6.84% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #112 | $3,563.0万 | 52.8万股 | $2,883.2万 | 52.0万股 | +7,988股+1.54% | 加仓 |
| APIS CAPITAL ADVISORS, LLC |
| 3.27% | 2.04% | #6 | $3,354.8万 | 49.7万股 | $1,319.9万 | 23.8万股 | +25.9万股+108.82% | 加仓 |
| Sofinnova Investments, Inc. |
| 1.72% | 0.52% | #10 | $3,331.4万 | 49.4万股 | $1,376.8万 | 24.8万股 | +24.5万股+98.80% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | 0.01% | #54 | $3,298.4万 | 48.9万股 | $2,729.3万 | 49.2万股 | -3,469股-0.70% | 减仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #71 | $2,839.5万 | 42.1万股 | $1,752.9万 | 31.6万股 | +10.5万股+33.09% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #109 | $2,820.2万 | 41.8万股 | $2,779.0万 | 50.1万股 | -8.3万股-16.62% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #90 | $2,792.3万 | 41.4万股 | $1,337.4万 | 24.1万股 | +17.3万股+71.54% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.04% | 0.03% | #38 | $2,643.8万 | 39.2万股 | $2,019.4万 | 36.4万股 | +2.8万股+7.57% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.02% | 0.02% | #42 | $2,190.0万 | 32.4万股 | $1,484.7万 | 26.8万股 | +5.7万股+21.20% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.02% | #57 | $1,775.2万 | 26.3万股 | $2,579.4万 | 46.5万股 | -20.2万股-43.45% | 减仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | — | #63 | $1,748.2万 | 25.9万股 | $0 | 0股 | +25.9万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #137 | $1,735.4万 | 25.7万股 | $4,765.3万 | 155.6万股 | -129.9万股-83.48% | 减仓 |
| Coppell Advisory Solutions LLC |
| 1.37% | — | #11 | $1,657.6万 | 3,638股 | $0 | 0股 | +3,638股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #142 | $1,623.4万 | 24.1万股 | $2,621.6万 | 47.3万股 | -23.2万股-49.12% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.02% | #55 | $1,544.2万 | 22.9万股 | $1,412.8万 | 25.5万股 | -2.6万股-10.19% | 减仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| 0.01% | <0.01% | #75 | $1,492.8万 | 21.7万股 | $713.7万 | 12.6万股 | +9.1万股+72.57% | 加仓 |
| Empowered FundsEmpowered Funds, LLC |
| 0.07% | — | #30 | $1,390.6万 | 20.6万股 | $0 | 0股 | +20.6万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #114 | $1,368.7万 | 20.3万股 | $1,017.8万 | 18.4万股 | +1.9万股+10.49% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #108 | $1,365.6万 | 20.2万股 | $1,068.6万 | 19.3万股 | +9,618股+4.99% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #128 | $1,363.9万 | 20.2万股 | $671.6万 | 12.1万股 | +8.1万股+66.85% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #100 | $1,251.7万 | 18.5万股 | $0 | 0股 | +18.5万股 | 新买入 |
| Greenhaven Road Investment Management, L.P. |
| 7.5% | — | #3 | $1,154.6万 | 17.1万股 | $0 | 0股 | +17.1万股 | 新买入 |
| 胜利资本管理VICTORY CAPITAL MANAGEMENT INC |
| 0.01% | <0.01% | #73 | $1,142.3万 | 16.9万股 | $600.1万 | 10.8万股 | +6.1万股+56.40% | 加仓 |
| 麦肯齐金融MACKENZIE FINANCIAL CORP |
| 0.01% | <0.01% | #64 | $1,019.1万 | 15.1万股 | $187.0万 | 3.4万股 | +11.7万股+347.74% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #120 | $991.1万 | 14.7万股 | $441.8万 | 8.0万股 | +6.7万股+84.30% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #103 | $990.4万 | 14.7万股 | $749.2万 | 13.5万股 | +1.2万股+8.62% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.02% | 0.02% | #48 | $951.9万 | 14.1万股 | $879.4万 | 15.9万股 | -1.8万股-11.06% | 减仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #59 | $722.9万 | 10.7万股 | $696.8万 | 12.6万股 | -1.9万股-14.75% | 减仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #116 | $721.9万 | 10.7万股 | $365.0万 | 6.6万股 | +4.1万股+62.49% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #102 | $669.0万 | 9.9万股 | $407.1万 | 7.3万股 | +2.6万股+35.02% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #158 | $651.4万 | 9.7万股 | $219.5万 | 4.0万股 | +5.7万股+143.83% | 加仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.01% | 0.01% | #65 | $632.7万 | 9.4万股 | $519.8万 | 9.4万股 | 00.00% | 持仓不变 |
| 保德信金融PRUDENTIAL FINANCIAL INC |
| 0.01% | <0.01% | #74 | $580.0万 | 8.6万股 | $355.2万 | 6.4万股 | +2.2万股+34.16% | 加仓 |
| DZ 银行 AG Deutsche Zentral Genossenschafts 银行 Frankfurt am MainDZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main |
| <0.01% | — | #82 | $566.6万 | 8.4万股 | $0 | 0股 | +8.4万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #171 | $529.3万 | 8.0万股 | $64.5万 | 1.2万股 | +6.9万股+589.02% | 加仓 |
