| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.06% | 0.05% | #59 | $3.55亿 | 954.4万股 | $2.72亿 | 856.0万股 | +98.3万股+11.49% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #116 | $2.61亿 | 700.3万股 | $1.70亿 | 537.0万股 | +163.3万股+30.40% | 加仓 |
| Kynam Capital Management, LP |
| 10.95% | 11.43% | #1 | $1.98亿 | 532.3万股 | $1.85亿 | 584.1万股 | -51.8万股-8.86% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #76 | $1.74亿 | 468.5万股 | $6,617.9万 | 208.6万股 | +259.9万股+124.57% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #113 | $1.45亿 | 390.0万股 | $8,894.8万 | 280.4万股 | +109.6万股+39.09% | 加仓 |
| 富达投资FMR LLC |
| 0.01% | 0.01% | #98 | $1.39亿 | 372.3万股 | $1.19亿 | 374.9万股 | -2.6万股-0.70% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #129 | $1.29亿 | 346.5万股 | $9,392.0万 | 296.1万股 | +50.4万股+17.02% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 1.59% | 0.67% | #17 | $1.09亿 | 293.9万股 | $4,072.8万 | 128.4万股 | +165.5万股+128.91% | 加仓 |
| Logos Global Management LP |
| 3.36% | 0.71% | #8 | $7,814.1万 | 210.0万股 | $1,427.4万 | 45.0万股 | +165.0万股+366.67% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #114 | $7,526.3万 | 202.2万股 | $5,355.6万 | 168.8万股 | +33.4万股+19.79% | 加仓 |
| Eversept Partners, LP |
| 3.45% | 2.99% | #7 | $6,645.5万 | 178.6万股 | $5,671.6万 | 178.8万股 | -2,075股-0.12% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #100 | $6,010.7万 | 161.5万股 | $3,135.3万 | 98.8万股 | +62.7万股+63.43% | 加仓 |
| Commodore Capital LP |
| 2.99% | 4.95% | #10 | $5,023.4万 | 135.0万股 | $8,553.7万 | 269.7万股 | -134.7万股-49.94% | 减仓 |
| Bellevue 集团Bellevue Group AG |
| 0.94% | 0.91% | #26 | $4,465.2万 | 120.0万股 | $3,806.4万 | 120.0万股 | 00.00% | 持仓不变 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.22% | 0.12% | #42 | $4,400.5万 | 118.3万股 | $2,110.6万 | 66.5万股 | +51.7万股+77.74% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #82 | $4,356.5万 | 117.1万股 | $3,976.2万 | 125.4万股 | -8.3万股-6.60% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #93 | $3,996.4万 | 107.4万股 | $3,359.6万 | 106.0万股 | +1.4万股+1.36% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.01% | #77 | $3,878.8万 | 104.2万股 | $2,716.2万 | 85.6万股 | +18.6万股+21.73% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.52% | 0.54% | #34 | $3,858.7万 | 103.7万股 | $3,289.4万 | 103.7万股 | 00.00% | 持仓不变 |
| Novo Holdings A/S |
| 2.22% | 3.08% | #12 | $3,814.0万 | 102.5万股 | $3,806.4万 | 120.0万股 | -17.5万股-14.58% | 减仓 |
| Elmind Capital, LP |
| 9.25% | 7.79% | #2 | $3,683.8万 | 99.0万股 | $2,743.8万 | 86.5万股 | +12.5万股+14.45% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.21% | — | #43 | $3,681.7万 | 98.9万股 | $0 | 0股 | +98.9万股 | 新买入 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.01% | 0.01% | #86 | $3,667.7万 | 98.6万股 | $3,215.3万 | 101.4万股 | -2.8万股-2.76% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.03% | 0.03% | #67 | $3,413.7万 | 91.7万股 | $2,930.0万 | 92.4万股 | -6,288股-0.68% | 减仓 |
| Foresite Capital Management VI LLC |
| 5.09% | 2.18% | #5 | $3,273.4万 | 88.0万股 | $1,002.1万 | 31.6万股 | +56.4万股+178.47% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #155 | $3,213.2万 | 86.4万股 | $1,996.0万 | 62.9万股 | +23.4万股+37.23% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.04% | 0.01% | #64 | $2,934.7万 | 78.9万股 | $464.8万 | 14.7万股 | +64.2万股+438.27% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #121 | $2,677.8万 | 72.0万股 | $1,831.1万 | 57.7万股 | +14.2万股+24.66% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.08% | 0.06% | #54 | $2,607.8万 | 70.1万股 | $1,586.4万 | 50.0万股 | +20.1万股+40.13% | 加仓 |
| Affinity Asset Advisors, LLC |
| 1.18% | 0.82% | #19 | $2,604.7万 | 70.0万股 | $1,586.0万 | 50.0万股 | +20.0万股+40.00% | 加仓 |
| Rock Springs Capital Management LP |
| 1.27% | 1.22% | #18 | $2,601.5万 | 69.9万股 | $2,062.7万 | 65.0万股 | +4.9万股+7.52% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.02% | <0.01% | #75 | $2,460.5万 | 66.1万股 | $434.6万 | 13.7万股 | +52.4万股+382.60% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #120 | $2,440.8万 | 65.6万股 | $1,730.3万 | 54.5万股 | +11.0万股+20.25% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.29% | 0.1% | #37 | $2,410.6万 | 64.8万股 | $682.5万 | 21.5万股 | +43.3万股+201.10% | 加仓 |
| ADAR1 Capital Management, LLC |
| 1.06% | 0.8% | #24 | $2,305.3万 | 62.0万股 | $1,357.0万 | 42.8万股 | +19.2万股+44.82% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #154 | $2,259.4万 | 60.7万股 | $2,247.8万 | 70.9万股 | -10.1万股-14.32% | 减仓 |
| Ikarian Capital, LLC |
| 2.34% | 1.48% | #11 | $2,204.7万 | 59.3万股 | $1,824.7万 | 57.5万股 | +1.7万股+3.00% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.07% | 0.02% | #57 | $2,130.4万 | 57.3万股 | $451.5万 | 14.2万股 | +43.0万股+302.27% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #102 | $2,115.2万 | 56.8万股 | $640.6万 | 20.2万股 | +36.7万股+181.49% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #108 | $2,057.6万 | 55.3万股 | $1,362.7万 | 43.0万股 | +12.3万股+28.72% | 加仓 |
| 5AM Venture Management, LLC |
| 6.43% | 4.38% | #4 | $1,850.3万 | 49.7万股 | $1,577.3万 | 49.7万股 | 00.00% | 持仓不变 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.03% | — | #70 | $1,834.1万 | 49.3万股 | $0 | 0股 | +49.3万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #139 | $1,793.5万 | 48.2万股 | $942.0万 | 29.7万股 | +18.5万股+62.30% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.08% | — | #53 | $1,788.5万 | 48.1万股 | $0 | 0股 | +48.1万股 | 新买入 |
| BRAIDWELL LP |
| 0.6% | 1.43% | #31 | $1,624.8万 | 43.7万股 | $4,301.5万 | 135.6万股 | -91.9万股-67.80% | 减仓 |
| Redmile Group, LLC |
| 1.08% | 0.55% | #23 | $1,614.6万 | 43.4万股 | $829.5万 | 26.2万股 | +17.2万股+65.93% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #103 | $1,505.9万 | 40.5万股 | $689.4万 | 21.7万股 | +18.7万股+86.21% | 加仓 |
| Palo Alto Investors LP |
| 2.17% | 1.44% | #13 | $1,487.9万 | 40.0万股 | $940.2万 | 29.6万股 | +10.3万股+34.90% | 加仓 |
| TSP Capital Management Group, LLC |
| 3.3% | 2.9% | #9 | $1,381.0万 | 37.1万股 | $1,189.9万 | 37.5万股 | -4,000股-1.07% | 减仓 |
| PFM Health Sciences, LP |
| 1.09% | 0.94% | #22 | $1,275.4万 | 34.3万股 | $1,030.8万 | 32.5万股 | +1.8万股+5.48% | 加仓 |
