| 富达投资FMR LLC |
| 0.02% | 0.02% | #82 | $3.54亿 | 506.8万股 | $3.10亿 | 430.3万股 | +76.5万股+17.77% | 加仓 |
| 两海资本Two Seas Capital LP |
| 4.28% | 1.97% | #5 | $2.16亿 | 309.2万股 | $1.41亿 | 195.9万股 | +113.3万股+57.83% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #127 | $2.05亿 | 294.2万股 | $4,983.6万 | 69.3万股 | +224.9万股+324.72% | 加仓 |
| BVF INC/IL |
| 4.27% | 5.87% | #6 | $1.67亿 | 239.1万股 | $1.84亿 | 256.0万股 | -16.9万股-6.58% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #96 | $1.05亿 | 149.7万股 | $6,498.5万 | 90.3万股 | +59.4万股+65.77% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #142 | $1.04亿 | 149.7万股 | $8,612.8万 | 119.7万股 | +30.0万股+25.04% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.06% | 0.05% | #63 | $8,391.2万 | 120.2万股 | $6,696.7万 | 93.1万股 | +27.1万股+29.14% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 1.63% | 0.57% | #12 | $6,981.0万 | 100.0万股 | $2,050.6万 | 28.5万股 | +71.5万股+250.88% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #123 | $6,538.1万 | 93.7万股 | $5,286.9万 | 92.9万股 | +7,409股+0.80% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #145 | $6,350.5万 | 91.0万股 | $1,760.8万 | 24.5万股 | +66.5万股+271.71% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #126 | $6,153.6万 | 88.1万股 | $2,496.2万 | 34.7万股 | +53.5万股+154.13% | 加仓 |
| Prosight Management, LP |
| 9.74% | 8.67% | #2 | $5,654.6万 | 81.0万股 | $5,288.3万 | 73.5万股 | +7.5万股+10.20% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.62% | 0.74% | #28 | $5,054.2万 | 72.4万股 | $4,158.7万 | 57.8万股 | +14.6万股+25.26% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.02% | 0.01% | #83 | $4,524.5万 | 64.8万股 | $2,908.8万 | 40.4万股 | +24.4万股+60.32% | 加仓 |
| 吉尔德·加尼翁·豪GILDER GAGNON HOWE & CO LLC |
| 0.43% | 0.23% | #35 | $4,194.7万 | 60.1万股 | $1,955.3万 | 27.2万股 | +32.9万股+121.11% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #116 | $3,483.8万 | 49.9万股 | $4,787.8万 | 66.5万股 | -16.6万股-25.00% | 减仓 |
| BRAIDWELL LP |
| 1.22% | 0.53% | #17 | $3,306.3万 | 47.4万股 | $1,602.3万 | 22.3万股 | +25.1万股+112.67% | 加仓 |
| Sofinnova Investments, Inc. |
| 1.7% | 1.39% | #11 | $3,293.4万 | 47.2万股 | $3,666.2万 | 51.0万股 | -3.8万股-7.42% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.1% | 0.11% | #56 | $3,287.2万 | 47.1万股 | $2,988.3万 | 41.5万股 | +5.6万股+13.37% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.61% | 0.39% | #29 | $3,248.6万 | 46.5万股 | $1,978.6万 | 27.5万股 | +19.0万股+69.22% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #118 | $2,990.7万 | 42.8万股 | $2,303.6万 | 32.0万股 | +10.8万股+33.80% | 加仓 |
| EMERALD ADVISERS, LLC |
| 0.64% | 0.9% | #26 | $2,723.7万 | 39.0万股 | $2,839.2万 | 39.5万股 | -4,446股-1.13% | 减仓 |
| LORD, ABBETT & CO. LLC |
| 0.08% | 0.1% | #59 | $2,664.1万 | 38.2万股 | $2,914.6万 | 40.5万股 | -2.3万股-5.79% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #164 | $2,433.2万 | 34.9万股 | $521.6万 | 7.2万股 | +27.6万股+380.80% | 加仓 |
| DAFNA Capital Management LLC |
| 4.24% | 2.7% | #7 | $2,222.6万 | 31.8万股 | $1,188.5万 | 16.5万股 | +15.3万股+92.75% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #132 | $2,153.9万 | 30.9万股 | $565.5万 | 7.9万股 | +23.0万股+292.54% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.3% | — | #40 | $2,094.3万 | 30.0万股 | $0 | 0股 | +30.0万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #131 | $1,989.4万 | 28.5万股 | $1,208.8万 | 16.8万股 | +11.7万股+69.62% | 加仓 |
| 22NW, LP |
| 18.75% | 15.92% | #1 | $1,962.5万 | 28.1万股 | $2,022.6万 | 28.1万股 | 00.00% | 持仓不变 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| 0.01% | 0.02% | #87 | $1,904.8万 | 27.3万股 | $2,008.5万 | 27.9万股 | -6,300股-2.26% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #124 | $1,831.5万 | 26.2万股 | $232.8万 | 3.2万股 | +23.0万股+710.86% | 加仓 |
| 近水资本市场Nearwater Capital Markets, Ltd |
| 0.31% | 0.44% | #38 | $1,825.5万 | 26.2万股 | $1,881.5万 | 26.2万股 | 00.00% | 持仓不变 |
| EMERALD MUTUAL FUND ADVISERS 信托EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.63% | 0.89% | #27 | $1,784.3万 | 25.6万股 | $1,842.7万 | 25.6万股 | -519股-0.20% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.79% | 0.68% | #24 | $1,704.6万 | 24.4万股 | $1,160.2万 | 16.1万股 | +8.3万股+51.43% | 加仓 |
| Creek Drive Management Group LLC |
| 8.24% | 2.89% | #3 | $1,696.4万 | 24.3万股 | $1,269.2万 | 17.6万股 | +6.7万股+37.76% | 加仓 |
| SEVEN GRAND MANAGERS, LLC |
| 0.67% | 0.6% | #25 | $1,675.4万 | 24.0万股 | $899.4万 | 12.5万股 | +11.5万股+92.00% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #110 | $1,674.3万 | 24.0万股 | $659.6万 | 9.2万股 | +14.8万股+161.62% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #119 | $1,672.5万 | 24.0万股 | $1,218.2万 | 16.9万股 | +7.0万股+41.50% | 加仓 |
| LMR合伙人LMR Partners LLP |
| 0.06% | 0.01% | #65 | $1,605.6万 | 23.0万股 | $347.5万 | 4.8万股 | +18.2万股+376.25% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #155 | $1,595.1万 | 22.8万股 | $913.3万 | 12.7万股 | +10.2万股+80.00% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | — | #152 | $1,503.0万 | 21.5万股 | $0 | 0股 | +21.5万股 | 新买入 |
| Bronte Capital Management Pty Ltd. |
| 1.49% | 2.86% | #13 | $1,385.3万 | 19.8万股 | $2,883.4万 | 40.1万股 | -20.2万股-50.49% | 减仓 |
| Caption管理Caption Management, LLC |
| 0.06% | 0.11% | #62 | $1,376.7万 | 19.7万股 | $1,834.7万 | 25.5万股 | -5.8万股-22.67% | 减仓 |
| GREAT POINT PARTNERS LLC |
| 2.31% | 5.23% | #10 | $1,221.7万 | 17.5万股 | $2,276.9万 | 31.6万股 | -14.1万股-44.70% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #138 | $1,158.4万 | 16.6万股 | $983.8万 | 13.7万股 | +2.9万股+21.36% | 加仓 |
| Quinn Opportunity Partners LLC |
| 0.5% | 0.67% | #31 | $1,068.6万 | 15.3万股 | $1,289.7万 | 17.9万股 | -2.6万股-14.60% | 减仓 |
| Rhenman & Partners Asset Management AB |
| 0.93% | 0.52% | #21 | $986.1万 | 14.1万股 | $424.5万 | 5.9万股 | +8.2万股+139.41% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.03% | #95 | $911.2万 | 13.1万股 | $2,810.9万 | 39.1万股 | -26.0万股-66.59% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.31% | — | #39 | $896.1万 | 12.8万股 | $0 | 0股 | +12.8万股 | 新买入 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. |
| 0.47% | 0.75% | #33 | $857.0万 | 12.3万股 | $880.1万 | 12.2万股 | +441股+0.36% | 加仓 |
