| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 2.39% | 3.96% | #2 | $4.78亿 | 3,278.6万股 | $6.90亿 | 3,639.1万股 | -360.5万股-9.91% | 减仓 |
| 富达投资FMR LLC |
| 0.01% | 0.01% | #81 | $1.46亿 | 1,004.4万股 | $2.06亿 | 1,085.3万股 | -80.9万股-7.46% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #95 | $1.39亿 | 953.7万股 | $1.33亿 | 702.8万股 | +250.9万股+35.69% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #124 | $1.39亿 | 952.9万股 | $1.83亿 | 965.4万股 | -12.5万股-1.29% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #132 | $8,355.1万 | 573.4万股 | $1.08亿 | 571.2万股 | +2.3万股+0.40% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #67 | $7,731.1万 | 530.6万股 | $7,015.8万 | 370.0万股 | +160.6万股+43.40% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | 0.01% | #107 | $7,346.5万 | 504.2万股 | $9,922.2万 | 523.3万股 | -19.1万股-3.65% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #85 | $6,576.0万 | 451.3万股 | $589.1万 | 31.1万股 | +420.3万股+1,352.52% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.02% | #86 | $5,673.3万 | 389.4万股 | $1.57亿 | 827.8万股 | -438.4万股-52.96% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.06% | 0.02% | #30 | $5,387.7万 | 369.8万股 | $1,518.9万 | 80.1万股 | +289.7万股+361.60% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #115 | $4,995.0万 | 342.7万股 | $6,288.7万 | 331.6万股 | +11.1万股+3.36% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #90 | $4,189.0万 | 287.5万股 | $2,011.5万 | 106.1万股 | +181.4万股+171.00% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | 0.01% | #114 | $3,498.3万 | 240.1万股 | $4,570.7万 | 241.1万股 | -9,694股-0.40% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #61 | $3,422.6万 | 234.9万股 | $239.4万 | 12.6万股 | +222.3万股+1,760.32% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | — | #37 | $2,898.8万 | 199.0万股 | $0 | 0股 | +199.0万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.01% | #44 | $2,774.5万 | 190.4万股 | $1,039.6万 | 54.8万股 | +135.6万股+247.28% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.03% | 0.01% | #49 | $2,668.7万 | 183.2万股 | $1,163.9万 | 61.4万股 | +121.8万股+198.37% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.03% | 0.02% | #43 | $2,467.6万 | 169.4万股 | $1,261.5万 | 66.5万股 | +102.8万股+154.54% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #140 | $2,112.7万 | 145.0万股 | $3,980.8万 | 192.7万股 | -47.7万股-24.75% | 减仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | <0.01% | #126 | $2,014.3万 | 138.3万股 | $1,963.7万 | 101.8万股 | +36.5万股+35.81% | 加仓 |
| Logos Global Management LP |
| 0.85% | — | #8 | $1,967.0万 | 135.0万股 | $0 | 0股 | +135.0万股 | 新买入 |
| Octagon Capital Advisors LP |
| 1.64% | — | #6 | $1,821.3万 | 125.0万股 | $0 | 0股 | +125.0万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.03% | #71 | $1,811.9万 | 124.4万股 | $4,251.3万 | 224.2万股 | -99.9万股-44.54% | 减仓 |
| Kynam Capital Management, LP |
| 0.97% | — | #7 | $1,748.4万 | 120.0万股 | $0 | 0股 | +120.0万股 | 新买入 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.02% | 0.03% | #56 | $1,643.5万 | 113.4万股 | $2,396.3万 | 132.3万股 | -18.9万股-14.27% | 减仓 |
| DIADEMA PARTNERS LP |
| 2.01% | — | #4 | $1,632.1万 | 112.0万股 | $0 | 0股 | +112.0万股 | 新买入 |
| LMR合伙人LMR Partners LLP |
| 0.06% | 0.03% | #32 | $1,481.3万 | 101.7万股 | $1,298.0万 | 68.5万股 | +33.2万股+48.50% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #131 | $1,423.3万 | 97.7万股 | $1,821.8万 | 96.1万股 | +1.6万股+1.66% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #109 | $1,408.3万 | 96.7万股 | $1,771.6万 | 93.4万股 | +3.2万股+3.45% | 加仓 |
| APEIRON CAPITAL Ltd |
| 9% | 23.21% | #1 | $1,401.4万 | 96.2万股 | $2,482.1万 | 130.9万股 | -34.7万股-26.53% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #152 | $1,260.3万 | 86.5万股 | $1,135.1万 | 59.9万股 | +26.6万股+44.48% | 加仓 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.01% | <0.01% | #72 | $1,197.1万 | 83.6万股 | $426.9万 | 25.1万股 | +58.5万股+232.53% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #101 | $1,084.0万 | 74.4万股 | $663.5万 | 35.0万股 | +39.4万股+112.61% | 加仓 |
| Rock Springs Capital Management LP |
| 0.51% | 0.79% | #9 | $1,041.8万 | 71.5万股 | $1,346.2万 | 71.0万股 | +5,000股+0.70% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.02% | #74 | $1,015.1万 | 69.7万股 | $1,860.3万 | 98.1万股 | -28.4万股-28.99% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #145 | $923.4万 | 63.4万股 | $1,102.7万 | 58.2万股 | +5.2万股+8.97% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #156 | $923.3万 | 63.4万股 | $568.6万 | 30.0万股 | +33.4万股+111.30% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.01% | #77 | $841.0万 | 57.7万股 | $901.1万 | 47.5万股 | +10.2万股+21.45% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #113 | $790.0万 | 54.2万股 | $811.2万 | 44.4万股 | +9.8万股+22.18% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.04% | 0.05% | #42 | $775.0万 | 53.2万股 | $945.7万 | 54.1万股 | -8,230股-1.52% | 减仓 |
| Caption管理Caption Management, LLC |
| 0.04% | 0.03% | #41 | $770.3万 | 52.9万股 | $493.0万 | 26.0万股 | +26.9万股+103.35% | 加仓 |
| Elmind Capital, LP |
| 1.81% | — | #5 | $719.5万 | 49.4万股 | $0 | 0股 | +49.4万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #141 | $643.9万 | 44.2万股 | $688.0万 | 36.3万股 | +7.9万股+21.79% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #146 | $628.4万 | 43.1万股 | $767.3万 | 40.5万股 | +2.7万股+6.58% | 加仓 |
| WorldQuant千禧顾问WORLDQUANT MILLENNIUM ADVISORS LLC |
| 0.02% | <0.01% | #51 | $628.0万 | 43.1万股 | $110.5万 | 5.8万股 | +37.3万股+639.68% | 加仓 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #87 | $620.8万 | 42.6万股 | $1,814.3万 | 95.7万股 | -53.1万股-55.47% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #170 | $607.3万 | 41.7万股 | $997.5万 | 52.6万股 | -10.9万股-20.77% | 减仓 |
| 跳跃金融Jump Financial, LLC |
| 0.05% | 0.03% | #35 | $567.7万 | 39.0万股 | $219.4万 | 11.6万股 | +27.4万股+236.64% | 加仓 |
| QVT Financial LP |
| 0.31% | 0.5% | #13 | $525.3万 | 36.1万股 | $683.6万 | 36.1万股 | 00.00% | 持仓不变 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| 0.03% | — | #48 | $510.0万 | 35.0万股 | $0 | 0股 | +35.0万股 | 新买入 |
