| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #108 | $2.47亿 | 574.8万股 | $2.05亿 | 508.8万股 | +66.0万股+12.96% | 加仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 2.21% | 2.33% | #11 | $2.46亿 | 572.4万股 | $2.37亿 | 588.9万股 | -16.5万股-2.80% | 减仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #94 | $1.78亿 | 414.9万股 | $1.35亿 | 336.4万股 | +78.5万股+23.34% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.02% | #69 | $1.72亿 | 401.3万股 | $1.84亿 | 457.4万股 | -56.1万股-12.27% | 减仓 |
| 深轨资本Deep Track Capital, LP |
| 2.5% | 2.7% | #10 | $1.72亿 | 400.0万股 | $1.65亿 | 410.6万股 | -10.6万股-2.58% | 减仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.75% | 1.77% | #12 | $1.68亿 | 391.6万股 | $1.50亿 | 372.2万股 | +19.4万股+5.22% | 加仓 |
| Kynam Capital Management, LP |
| 6.85% | 8.43% | #1 | $1.24亿 | 289.0万股 | $1.37亿 | 339.8万股 | -50.8万股-14.95% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #89 | $1.20亿 | 279.9万股 | $797.8万 | 27.5万股 | +252.5万股+919.75% | 加仓 |
| Sofinnova Investments, Inc. |
| 6.2% | 4.27% | #2 | $1.20亿 | 279.4万股 | $1.12亿 | 279.4万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| 0.01% | 0.01% | #97 | $1.19亿 | 277.4万股 | $1.08亿 | 267.6万股 | +9.8万股+3.65% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #123 | $1.18亿 | 275.5万股 | $1.08亿 | 268.4万股 | +7.2万股+2.68% | 加仓 |
| Eversept Partners, LP |
| 4.93% | 4.61% | #3 | $9,495.0万 | 221.3万股 | $8,743.1万 | 217.3万股 | +3.9万股+1.82% | 加仓 |
| Logos Global Management LP |
| 4.06% | — | #6 | $9,440.2万 | 220.0万股 | $0 | 0股 | +220.0万股 | 新买入 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 2.97% | 3.08% | #8 | $7,509.3万 | 175.0万股 | $6,436.8万 | 160.0万股 | +15.0万股+9.38% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 1.54% | 1.64% | #14 | $7,341.1万 | 171.1万股 | $6,882.4万 | 171.1万股 | +37股+0.00% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #106 | $7,263.8万 | 169.2万股 | $6,317.7万 | 157.0万股 | +12.2万股+7.79% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.02% | #66 | $6,400.8万 | 159.1万股 | $6,655.3万 | 131.4万股 | +27.7万股+21.06% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #98 | $5,925.2万 | 138.1万股 | $4,562.0万 | 113.4万股 | +24.7万股+21.77% | 加仓 |
| Frontier资本管理FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.52% | 0.23% | #26 | $5,558.6万 | 129.5万股 | $2,218.7万 | 55.1万股 | +74.4万股+134.89% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.05% | 0.04% | #52 | $5,362.5万 | 124.9万股 | $4,230.5万 | 105.2万股 | +19.8万股+18.81% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| 0.01% | 0.01% | #77 | $4,729.1万 | 110.2万股 | $2,142.1万 | 53.2万股 | +57.0万股+106.98% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.04% | 0.02% | #56 | $4,647.9万 | 108.3万股 | $2,179.7万 | 54.2万股 | +54.1万股+99.92% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.13% | 0.15% | #38 | $4,295.4万 | 100.1万股 | $4,027.2万 | 100.1万股 | 00.00% | 持仓不变 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #72 | $3,717.1万 | 86.6万股 | $2,930.1万 | 72.8万股 | +13.8万股+18.94% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #147 | $2,758.6万 | 64.3万股 | $2,224.6万 | 55.3万股 | +9.0万股+16.26% | 加仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| 0.02% | 0.01% | #65 | $2,757.2万 | 64.3万股 | $1,168.6万 | 29.0万股 | +35.2万股+121.21% | 加仓 |
| GREAT POINT PARTNERS LLC |
| 4.87% | 1.84% | #4 | $2,578.2万 | 60.1万股 | $802.0万 | 19.9万股 | +40.1万股+201.40% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #138 | $2,532.1万 | 59.0万股 | $2,372.3万 | 59.0万股 | +419股+0.07% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #117 | $2,493.6万 | 58.1万股 | $2,089.7万 | 51.9万股 | +6.2万股+11.87% | 加仓 |
| BRAIDWELL LP |
| 0.9% | 0.7% | #20 | $2,423.2万 | 56.5万股 | $2,107.3万 | 52.4万股 | +4.1万股+7.81% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #113 | $2,338.7万 | 54.5万股 | $2,110.3万 | 52.5万股 | +2.0万股+3.90% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #103 | $2,265.0万 | 52.8万股 | $1,121.5万 | 27.9万股 | +24.9万股+89.35% | 加仓 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.02% | 0.02% | #73 | $2,204.0万 | 51.1万股 | $1,845.5万 | 48.4万股 | +2.6万股+5.45% | 加仓 |
| Davern Capital Partners, LP |
| 3.65% | — | #7 | $2,140.5万 | 49.9万股 | $0 | 0股 | +49.9万股 | 新买入 |
| 康得利安资管Candriam S.C.A. |
| 0.09% | 0.11% | #43 | $2,006.7万 | 46.8万股 | $2,276.6万 | 45.0万股 | +1.9万股+4.13% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #101 | $1,998.8万 | 46.6万股 | $1,776.2万 | 44.2万股 | +2.4万股+5.50% | 加仓 |
| Elmind Capital, LP |
| 4.71% | 5.51% | #5 | $1,873.1万 | 43.7万股 | $1,941.1万 | 48.3万股 | -4.6万股-9.53% | 减仓 |
| Rock Springs Capital Management LP |
| 0.9% | 1.19% | #21 | $1,834.8万 | 42.8万股 | $2,025.9万 | 50.4万股 | -7.6万股-15.09% | 减仓 |
| Ikarian Capital, LLC |
| 1.74% | 0.89% | #13 | $1,637.9万 | 38.2万股 | $1,093.0万 | 27.2万股 | +11.0万股+40.49% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #67 | $1,608.9万 | 37.5万股 | $1,687.9万 | 42.0万股 | -4.5万股-10.63% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.3% | 0.29% | #32 | $1,585.9万 | 37.0万股 | $1,486.9万 | 37.0万股 | 00.00% | 持仓不变 |
| 时代广场资本管理TimesSquare Capital Management, LLC |
| 0.23% | 0.16% | #33 | $1,564.3万 | 36.5万股 | $935.2万 | 23.2万股 | +13.2万股+56.82% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #152 | $1,303.3万 | 30.4万股 | $1,239.6万 | 30.8万股 | -4,383股-1.42% | 减仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.16% | 0.21% | #37 | $1,287.3万 | 30.0万股 | $1,199.5万 | 29.8万股 | +1,836股+0.62% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #116 | $1,280.5万 | 29.8万股 | $1,603.6万 | 39.9万股 | -10.0万股-25.14% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.03% | #71 | $1,199.5万 | 28.0万股 | $1,839.7万 | 45.7万股 | -17.8万股-38.87% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #104 | $1,195.7万 | 27.9万股 | $1,180.7万 | 29.3万股 | -1.5万股-5.06% | 减仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #107 | $1,144.7万 | 26.7万股 | $1,005.6万 | 25.0万股 | +1.7万股+6.72% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #142 | $1,090.7万 | 25.4万股 | $755.9万 | 18.8万股 | +6.6万股+35.28% | 加仓 |
| Affinity Asset Advisors, LLC |
| 0.48% | 0.52% | #27 | $1,072.8万 | 25.0万股 | $1,005.8万 | 25.0万股 | 00.00% | 持仓不变 |
