| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 11.9% | 9.69% | #2 | $6.31亿 | 1,551.8万股 | $4.89亿 | 1,551.8万股 | 00.00% | 持仓不变 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 7.77% | 4.74% | #3 | $4.15亿 | 1,021.5万股 | $2.32亿 | 736.5万股 | +285.0万股+38.70% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 2.96% | 3.48% | #12 | $3.41亿 | 839.3万股 | $3.28亿 | 1,042.8万股 | -203.6万股-19.52% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #101 | $2.68亿 | 660.6万股 | $2.04亿 | 647.3万股 | +13.3万股+2.06% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.1% | — | #44 | $2.47亿 | 607.5万股 | $0 | 0股 | +607.5万股 | 新买入 |
| 富达投资FMR LLC |
| 0.01% | <0.01% | #78 | $2.23亿 | 548.9万股 | $3,203.7万 | 101.7万股 | +447.2万股+439.71% | 加仓 |
| Novo Holdings A/S |
| 12.66% | 13.65% | #1 | $2.17亿 | 535.0万股 | $1.69亿 | 535.0万股 | 00.00% | 持仓不变 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.11% | 1.04% | #22 | $1.92亿 | 472.9万股 | $1.41亿 | 447.8万股 | +25.1万股+5.60% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 2.67% | 2.72% | #14 | $1.78亿 | 437.4万股 | $1.39亿 | 442.4万股 | -5.0万股-1.13% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #109 | $1.57亿 | 386.1万股 | $1.19亿 | 378.8万股 | +7.3万股+1.91% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.75% | 1.19% | #28 | $1.50亿 | 370.2万股 | $2.07亿 | 657.6万股 | -287.4万股-43.71% | 减仓 |
| Siren, L.L.C. |
| 2.62% | 3.87% | #15 | $1.29亿 | 318.5万股 | $1.40亿 | 443.0万股 | -124.6万股-28.12% | 减仓 |
| Cormorant Asset Management, LP |
| 5.18% | 5.16% | #5 | $1.02亿 | 251.0万股 | $1.03亿 | 326.0万股 | -75.0万股-23.01% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #91 | $8,834.8万 | 217.4万股 | $5,639.1万 | 179.0万股 | +38.4万股+21.47% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 3.21% | 2.41% | #9 | $8,126.0万 | 200.0万股 | $5,040.0万 | 160.0万股 | +40.0万股+25.00% | 加仓 |
| BRAIDWELL LP |
| 3% | 2.47% | #10 | $8,113.7万 | 199.7万股 | $7,394.9万 | 234.8万股 | -35.1万股-14.94% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #97 | $7,917.1万 | 194.9万股 | $1,410.6万 | 87.0万股 | +107.9万股+124.06% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #126 | $7,426.9万 | 182.8万股 | $5,408.0万 | 171.7万股 | +11.1万股+6.47% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.01% | #66 | $6,674.9万 | 211.9万股 | $4,273.6万 | 172.2万股 | +39.7万股+23.04% | 加仓 |
| MPM BioImpact LLC |
| 4.02% | 4.04% | #6 | $6,585.2万 | 162.1万股 | $5,231.2万 | 166.1万股 | -4.0万股-2.40% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #99 | $6,331.2万 | 155.8万股 | $4,181.2万 | 132.7万股 | +23.1万股+17.40% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.05% | 0.03% | #51 | $5,088.9万 | 125.3万股 | $2,601.6万 | 82.6万股 | +42.7万股+51.65% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #79 | $4,630.9万 | 114.0万股 | $3,841.3万 | 122.0万股 | -8.0万股-6.56% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #69 | $4,579.3万 | 112.7万股 | $3,613.6万 | 114.7万股 | -2.0万股-1.75% | 减仓 |
| First Light Asset Management, LLC |
| 2.7% | 2.83% | #13 | $4,449.7万 | 109.5万股 | $3,155.8万 | 100.2万股 | +9.3万股+9.32% | 加仓 |
| 胜利资本管理VICTORY CAPITAL MANAGEMENT INC |
| 0.02% | 0.02% | #68 | $3,668.4万 | 90.3万股 | $2,485.5万 | 78.9万股 | +11.4万股+14.43% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #111 | $3,317.5万 | 81.7万股 | $218.7万 | 6.9万股 | +74.7万股+1,076.08% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #140 | $3,195.4万 | 78.6万股 | $1,755.4万 | 55.7万股 | +22.9万股+41.13% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #115 | $2,727.4万 | 67.1万股 | $1,816.2万 | 57.7万股 | +9.5万股+16.43% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.04% | 0.04% | #56 | $2,632.5万 | 64.8万股 | $2,602.1万 | 82.6万股 | -17.8万股-21.56% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #108 | $2,521.2万 | 62.1万股 | $1,878.4万 | 59.6万股 | +2.4万股+4.06% | 加仓 |
| Tyro Capital Management LLC |
| 5.59% | — | #4 | $2,490.5万 | 61.3万股 | $0 | 0股 | +61.3万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #129 | $2,435.6万 | 59.9万股 | $1,983.9万 | 63.0万股 | -3.0万股-4.82% | 减仓 |
| Parkman Healthcare Partners LLC |
| 2.4% | 1.05% | #16 | $2,344.5万 | 57.7万股 | $1,016.9万 | 32.3万股 | +25.4万股+78.74% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.04% | 0.03% | #55 | $2,335.9万 | 57.5万股 | $2,076.1万 | 65.9万股 | -8.4万股-12.77% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #89 | $2,227.7万 | 54.8万股 | $1,643.4万 | 52.2万股 | +2.7万股+5.09% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #124 | $2,156.7万 | 53.1万股 | $1,523.8万 | 48.4万股 | +4.7万股+9.73% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | <0.01% | #130 | $2,072.7万 | 51.0万股 | $105.1万 | 4.8万股 | +46.2万股+968.24% | 加仓 |
| Opaleye Management Inc. |
| 1.84% | 2.07% | #17 | $2,031.5万 | 50.0万股 | $1,575.0万 | 50.0万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | — | #62 | $1,877.1万 | 46.2万股 | $0 | 0股 | +46.2万股 | 新买入 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.63% | 1.85% | #31 | $1,832.0万 | 45.1万股 | $4,567.2万 | 145.0万股 | -99.9万股-68.90% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #100 | $1,685.0万 | 41.5万股 | $1,057.7万 | 33.6万股 | +7.9万股+23.50% | 加仓 |
| Sofinnova Investments, Inc. |
| 0.8% | 0.46% | #26 | $1,547.7万 | 38.1万股 | $1,217.5万 | 38.6万股 | -5,575股-1.44% | 减仓 |
| 安大略医疗养老基金(HOOPP)HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.02% | 0.02% | #71 | $1,357.1万 | 33.4万股 | $1,273.2万 | 40.4万股 | -7.0万股-17.36% | 减仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #106 | $1,290.3万 | 31.8万股 | $62.0万 | 2.0万股 | +29.8万股+1,513.81% | 加仓 |
| Squadron Capital Management LLC |
| 3.66% | 4.04% | #8 | $1,178.3万 | 29.0万股 | $1,102.5万 | 35.0万股 | -6.0万股-17.14% | 减仓 |
| Universal投资服务Universal- Beteiligungs- und Servicegesellschaft mbH |
| 0.02% | 0.01% | #72 | $1,151.2万 | 28.3万股 | $892.4万 | 28.3万股 | +21股+0.01% | 加仓 |
| DIADEMA PARTNERS LP |
| 1.37% | 1.14% | #20 | $1,106.0万 | 27.2万股 | $669.4万 | 21.3万股 | +6.0万股+28.10% | 加仓 |
| 保德信金融PRUDENTIAL FINANCIAL INC |
| 0.01% | <0.01% | #75 | $1,059.3万 | 26.1万股 | $33.4万 | 1.1万股 | +25.0万股+2,358.51% | 加仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.18% | 0.18% | #39 | $1,042.6万 | 25.7万股 | $832.2万 | 26.4万股 | -7,596股-2.88% | 减仓 |
