| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 23.83% | 24.92% | #1 | $27.42亿 | 1,028.1万股 | $23.52亿 | 1,028.1万股 | 00.00% | 持仓不变 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 1.18% | 0.97% | #30 | $18.02亿 | 675.5万股 | $14.09亿 | 616.2万股 | +59.3万股+9.62% | 加仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 12.24% | 11.39% | #4 | $13.63亿 | 511.1万股 | $11.58亿 | 506.3万股 | +4.9万股+0.96% | 加仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 4.18% | 4.62% | #10 | $12.80亿 | 479.8万股 | $11.01亿 | 481.3万股 | -1.5万股-0.32% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.4% | — | #46 | $9.73亿 | 364.9万股 | $0 | 0股 | +364.9万股 | 新买入 |
| 富达投资FMR LLC |
| 0.04% | 0.05% | #116 | $9.46亿 | 354.6万股 | $8.87亿 | 387.7万股 | -33.1万股-8.54% | 减仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 1.11% | 1.19% | #31 | $7.03亿 | 263.4万股 | $7.39亿 | 323.0万股 | -59.6万股-18.46% | 减仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | <0.01% | #183 | $5.90亿 | 221.2万股 | $1.51亿 | 66.1万股 | +155.1万股+234.59% | 加仓 |
| 资本国际投资者Capital International Investors |
| 0.11% | 0.11% | #84 | $5.30亿 | 198.9万股 | $4.48亿 | 195.9万股 | +3.0万股+1.52% | 加仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.16% | 0.14% | #67 | $5.00亿 | 187.5万股 | $4.26亿 | 186.1万股 | +1.5万股+0.79% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.1% | 0.1% | #87 | $4.97亿 | 186.3万股 | $4.69亿 | 205.2万股 | -18.9万股-9.23% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.08% | #102 | $4.13亿 | 154.9万股 | $4.02亿 | 175.8万股 | -20.9万股-11.89% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.17% | 0.16% | #66 | $3.74亿 | 140.1万股 | $3.20亿 | 139.7万股 | +3,456股+0.25% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 4.66% | 6.84% | #9 | $3.10亿 | 116.4万股 | $3.50亿 | 153.1万股 | -36.8万股-24.01% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.04% | #127 | $2.99亿 | 112.3万股 | $3.50亿 | 153.0万股 | -40.8万股-26.65% | 减仓 |
| 资本世界投资者Capital World Investors |
| 0.03% | 0.03% | #128 | $2.42亿 | 90.6万股 | $2.06亿 | 90.1万股 | +5,564股+0.62% | 加仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.11% | 0.11% | #80 | $2.33亿 | 87.4万股 | $2.05亿 | 89.6万股 | -2.3万股-2.55% | 减仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.39% | 0.53% | #47 | $1.65亿 | 61.7万股 | $1.49亿 | 65.2万股 | -3.5万股-5.34% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #167 | $1.49亿 | 56.0万股 | $1.30亿 | 56.6万股 | -6,658股-1.18% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #186 | $1.45亿 | 54.4万股 | $8,086.8万 | 40.7万股 | +13.8万股+33.84% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #206 | $1.37亿 | 51.4万股 | $1,997.6万 | 8.7万股 | +42.7万股+488.51% | 加仓 |
| 景顺Invesco Ltd. |
| 0.01% | 0.01% | #182 | $1.10亿 | 41.4万股 | $8,282.5万 | 36.2万股 | +5.2万股+14.38% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #172 | $1.08亿 | 40.7万股 | $1,546.2万 | 6.8万股 | +33.9万股+501.76% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #196 | $1.08亿 | 40.3万股 | $1,668.4万 | 7.3万股 | +33.0万股+452.71% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #166 | $1.07亿 | 40.2万股 | $4,742.5万 | 20.7万股 | +19.5万股+93.83% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.04% | 0.02% | #120 | $1.06亿 | 39.9万股 | $5,932.4万 | 27.8万股 | +12.1万股+43.53% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 2.34% | 2.4% | #19 | $1.00亿 | 37.5万股 | $8,577.4万 | 37.5万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| 0.01% | 0.01% | #197 | $9,698.4万 | 36.8万股 | $1.18亿 | 53.9万股 | -17.2万股-31.82% | 减仓 |
| FIL(富达国际)FIL Ltd |
| 0.07% | 0.08% | #103 | $9,217.0万 | 34.6万股 | $1.02亿 | 44.7万股 | -10.2万股-22.76% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.03% | 0.02% | #126 | $8,767.3万 | 32.9万股 | $4,323.6万 | 18.9万股 | +14.0万股+73.89% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.02% | 0.05% | #147 | $8,548.7万 | 32.1万股 | $2.03亿 | 88.8万股 | -56.7万股-63.90% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.01% | 0.01% | #163 | $8,519.4万 | 31.9万股 | $5,230.5万 | 22.9万股 | +9.1万股+39.68% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.06% | 0.04% | #109 | $8,193.7万 | 30.7万股 | $5,156.5万 | 22.5万股 | +8.2万股+36.27% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| 0.01% | <0.01% | #192 | $7,557.3万 | 28.3万股 | $1,747.5万 | 7.6万股 | +20.7万股+270.87% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #200 | $6,951.7万 | 26.1万股 | $4,540.4万 | 19.9万股 | +6.2万股+31.30% | 加仓 |
| Tri Locum Partners LP |
| 8.49% | 8.2% | #5 | $6,901.1万 | 25.9万股 | $5,840.2万 | 25.5万股 | +3,408股+1.33% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.23% | 0.82% | #29 | $6,520.1万 | 24.4万股 | $4,162.4万 | 18.2万股 | +6.2万股+34.33% | 加仓 |
| SEI投资SEI INVESTMENTS CO |
| 0.06% | 0.07% | #112 | $6,344.4万 | 23.8万股 | $8,031.8万 | 35.1万股 | -11.3万股-32.26% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.06% | 0.06% | #108 | $6,227.5万 | 23.4万股 | $5,690.7万 | 25.2万股 | -1.8万股-7.07% | 减仓 |
| PFM Health Sciences, LP |
| 5.34% | 3.64% | #7 | $6,219.1万 | 23.3万股 | $3,989.8万 | 17.4万股 | +5.9万股+33.67% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 1.31% | 0.78% | #27 | $6,005.3万 | 22.5万股 | $3,049.7万 | 13.3万股 | +9.2万股+68.87% | 加仓 |
| Spyglass Capital Management LLC |
| 3.11% | 5.96% | #12 | $5,745.1万 | 21.5万股 | $8,416.6万 | 36.8万股 | -15.3万股-41.46% | 减仓 |
| ARS Investment Partners, LLC |
| 2.45% | 2.49% | #18 | $5,613.4万 | 21.0万股 | $4,790.9万 | 20.9万股 | +1,006股+0.48% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 5.72% | 2.91% | #6 | $5,500.7万 | 20.6万股 | $2,851.3万 | 12.5万股 | +8.2万股+65.44% | 加仓 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| 0.06% | 0.05% | #104 | $5,115.4万 | 19.2万股 | $3,913.8万 | 17.1万股 | +2.1万股+12.09% | 加仓 |
| Empowered FundsEmpowered Funds, LLC |
| 0.26% | 0.07% | #58 | $4,994.9万 | 18.7万股 | $1,169.6万 | 5.1万股 | +13.6万股+266.23% | 加仓 |
| Allspring环球投资Allspring Global Investments Holdings, LLC |
| 0.07% | 0.07% | #100 | $4,786.4万 | 17.9万股 | $4,204.7万 | 18.4万股 | -5,486股-2.98% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.03% | #139 | $4,626.2万 | 17.3万股 | $7,071.7万 | 30.9万股 | -13.6万股-43.90% | 减仓 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| 0.15% | 0.31% | #71 | $4,572.8万 | 17.1万股 | $6,973.9万 | 30.5万股 | -13.3万股-43.77% | 减仓 |
| Rock Springs Capital Management LP |
| 2.2% | 2.62% | #21 | $4,500.9万 | 16.9万股 | $4,437.4万 | 19.4万股 | -2.5万股-13.02% | 减仓 |
