| 富达投资FMR LLC |
| 0.03% | 0.02% | #52 | $6.24亿 | 1,618.6万股 | $4.21亿 | 1,694.8万股 | -76.1万股-4.49% | 减仓 |
| 深轨资本Deep Track Capital, LP |
| 5.24% | 4.68% | #2 | $3.60亿 | 934.1万股 | $2.86亿 | 1,152.7万股 | -218.6万股-18.96% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #88 | $2.77亿 | 718.1万股 | $1.63亿 | 657.4万股 | +60.6万股+9.22% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 1.03% | 0.22% | #17 | $2.24亿 | 580.5万股 | $3,840.3万 | 154.6万股 | +425.9万股+275.49% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 1.05% | 0.78% | #15 | $2.09亿 | 543.5万股 | $1.36亿 | 545.8万股 | -2.3万股-0.42% | 减仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #80 | $1.78亿 | 461.7万股 | $1.13亿 | 453.8万股 | +7.9万股+1.74% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #66 | $1.75亿 | 453.5万股 | $3,158.0万 | 195.9万股 | +257.6万股+131.48% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 4.13% | 3.17% | #5 | $1.72亿 | 445.8万股 | $1.11亿 | 445.8万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #75 | $1.51亿 | 391.1万股 | $9,203.0万 | 370.5万股 | +20.6万股+5.55% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #104 | $1.40亿 | 363.9万股 | $8,992.2万 | 362.0万股 | +1.9万股+0.51% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.08% | 0.05% | #36 | $1.28亿 | 331.0万股 | $7,940.6万 | 319.7万股 | +11.4万股+3.55% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 1.05% | 0.79% | #16 | $1.22亿 | 317.8万股 | $7,893.8万 | 317.8万股 | 00.00% | 持仓不变 |
| 两海资本Two Seas Capital LP |
| 2.4% | 1.11% | #8 | $1.21亿 | 314.9万股 | $7,953.7万 | 320.2万股 | -5.3万股-1.67% | 减仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 1.38% | 2.41% | #11 | $1.13亿 | 293.6万股 | $1.36亿 | 546.5万股 | -252.9万股-46.28% | 减仓 |
| ADAR1 Capital Management, LLC |
| 4.14% | 3.92% | #4 | $8,980.2万 | 233.1万股 | $6,654.7万 | 267.9万股 | -34.8万股-13.00% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #83 | $8,611.5万 | 223.5万股 | $5,197.7万 | 209.2万股 | +14.3万股+6.81% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.06% | 0.06% | #41 | $8,561.8万 | 222.2万股 | $8,974.4万 | 361.3万股 | -139.1万股-38.49% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.24% | 0.19% | #25 | $7,613.0万 | 197.6万股 | $4,908.1万 | 197.6万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #74 | $7,047.9万 | 182.9万股 | $843.6万 | 34.0万股 | +149.0万股+438.63% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #78 | $6,747.3万 | 175.1万股 | $4,434.2万 | 178.5万股 | -3.4万股-1.90% | 减仓 |
| Alpine Global Management, LLC |
| 8.69% | 11.37% | #1 | $5,297.9万 | 137.5万股 | $6,550.1万 | 263.7万股 | -126.2万股-47.86% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #87 | $5,273.7万 | 136.9万股 | $3,025.8万 | 121.8万股 | +15.1万股+12.36% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.79% | 0.78% | #19 | $5,230.0万 | 135.7万股 | $3,967.9万 | 159.7万股 | -24.0万股-15.02% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.02% | — | #56 | $4,780.2万 | 124.1万股 | $0 | 0股 | +124.1万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #106 | $4,552.1万 | 118.1万股 | $2,219.9万 | 89.4万股 | +28.8万股+32.20% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.05% | 0.05% | #44 | $3,302.1万 | 85.7万股 | $2,883.3万 | 116.1万股 | -30.4万股-26.17% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #92 | $3,059.3万 | 79.4万股 | $1,671.2万 | 67.3万股 | +12.1万股+18.02% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.01% | #50 | $2,800.4万 | 72.7万股 | $478.2万 | 19.3万股 | +53.4万股+277.56% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #94 | $2,622.3万 | 68.1万股 | $1,640.5万 | 66.0万股 | +2.0万股+3.05% | 加仓 |
| Logos Global Management LP |
| 1.1% | 1.33% | #13 | $2,562.2万 | 66.5万股 | $2,670.3万 | 107.5万股 | -41.0万股-38.14% | 减仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.48% | 1.05% | #6 | $2,385.4万 | 61.9万股 | $1,029.0万 | 41.4万股 | +20.5万股+49.45% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #79 | $2,319.7万 | 60.2万股 | $599.1万 | 24.1万股 | +36.1万股+149.61% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #81 | $2,174.0万 | 56.4万股 | $1,352.6万 | 54.5万股 | +2.0万股+3.62% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.03% | 0.03% | #51 | $1,826.3万 | 47.4万股 | $1,251.1万 | 50.4万股 | -3.0万股-5.89% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #116 | $1,819.1万 | 47.2万股 | $1,700.4万 | 68.5万股 | -21.2万股-31.03% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.02% | 0.01% | #59 | $1,781.5万 | 46.2万股 | $1,173.4万 | 47.2万股 | -1.0万股-2.12% | 减仓 |
| Group One交易GROUP ONE TRADING LLC |
| 0.02% | <0.01% | #55 | $1,676.4万 | 43.5万股 | $51.1万 | 2.1万股 | +41.5万股+2,013.57% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| 0.02% | <0.01% | #54 | $1,278.9万 | 33.2万股 | $165.1万 | 6.6万股 | +26.5万股+399.24% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #86 | $1,266.4万 | 32.9万股 | $0 | 0股 | +32.9万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #77 | $1,233.2万 | 32.0万股 | $831.0万 | 33.5万股 | -1.4万股-4.33% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #146 | $1,226.8万 | 31.8万股 | $367.2万 | 14.8万股 | +17.1万股+115.41% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #125 | $1,139.7万 | 29.6万股 | $537.1万 | 21.6万股 | +8.0万股+36.80% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #140 | $1,099.3万 | 28.5万股 | $539.8万 | 21.7万股 | +6.8万股+31.30% | 加仓 |
| HighVista Strategies LLC |
| 2.44% | 1.54% | #7 | $1,070.6万 | 27.8万股 | $559.2万 | 22.5万股 | +5.3万股+23.42% | 加仓 |
| STEMPOINT CAPITAL LP |
| 1.52% | 3.47% | #10 | $1,065.5万 | 27.7万股 | $1,879.8万 | 84.6万股 | -57.0万股-67.33% | 减仓 |
| Tetragon Partners GP Ltd |
| 1.55% | 1.05% | #9 | $986.1万 | 25.6万股 | $542.8万 | 21.9万股 | +3.7万股+17.13% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.33% | 0.23% | #21 | $971.0万 | 25.2万股 | $571.3万 | 23.0万股 | +2.2万股+9.57% | 加仓 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 5.06% | 6.35% | #3 | $802.8万 | 20.8万股 | $888.3万 | 35.8万股 | -14.9万股-41.73% | 减仓 |
| Granahan 投资管理Granahan Investment Management, LLC |
| 0.28% | 0.29% | #22 | $795.2万 | 20.6万股 | $607.2万 | 24.4万股 | -3.8万股-15.57% | 减仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.07% | 0.04% | #38 | $615.9万 | 16.0万股 | $262.7万 | 10.6万股 | +5.4万股+51.12% | 加仓 |
